Update in Transplantation 2007

Corris, Paul A.; Christie, Jason D.

doi:10.1164/rccm.200802-247up

Cited by 25 publications

(13 citation statements)

References 66 publications

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“…Lung transplantation is a treatment option for patients with end‐stage lung disease (1). During the last two decades, considerable advances in organ preservation, surgical techniques, immunosuppressant and antibiotic therapy have contributed to improvement in postoperative survival (2).…”

Section: Introductionmentioning

confidence: 99%

Exercise Training After Lung Transplantation Improves Participation in Daily Activity: A Randomized Controlled Trial

Langer

Burtin

Schepers

et al. 2012

American Journal of Transplantation

148

178

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The effects of exercise training after lung transplantation have not been studied in a randomized controlled trial so far. We investigated whether 3 months of supervised training, initiated immediately after hospital discharge, improve functional recovery and cardiovascular morbidity of patients up to 1 year after lung transplantation. Patients older than 40 years, who experienced an uncomplicated postoperative period, were eligible for this single blind, parallel group study. Sealed envelopes were used to randomly allocate patients to 3 months of exercise training (n = 21) or a control intervention (n = 19). Minutes of daily walking time (primary outcome), physical fitness, quality of life and cardiovascular morbidity were compared between groups adjusting for baseline assessments in a mixed models analysis. After 1 year daily walking time in the treated patients (n = 18) was 85 ± 27 min and in the control group (n = 16) 54 ± 30 min (adjusted difference 26 min [95%CI 8-45 min, p = 0.006]). Quadriceps force (p = 0.001), 6-minute walking distance (p = 0.002) and self-reported physical functioning (p = 0.039) were significantly higher in the intervention group. Average 24 h ambulatory blood pressures were significantly lower in the treated patients (p ≤ 0.01). Based on these results patients should be strongly encouraged to participate in an exercise training intervention after lung transplantation.Key words: Activities of daily living, exercise, lung transplantation, rehabilitation Abbreviations: 6MWD, six-minute walking distance; BE, bronchiectasis; BMI, body mass index; CI, confidence interval; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in the first second; ICU, intensive care unit; MET, metabolic equivalent; PF, pulmonary fibrosis; QF, quadriceps force; RCT, randomized controlled trial; SSLTx, bilateral lung transplantation; VO2, max, peak oxygen consumption; Wmax, peak work rate.

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Section: Introductionmentioning

confidence: 99%

Exercise Training After Lung Transplantation Improves Participation in Daily Activity: A Randomized Controlled Trial

Langer

Burtin

Schepers

et al. 2012

American Journal of Transplantation

148

178

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“…Recent mathematical modeling of pediatric age patients with CF has suggested that little benefit is gained from lung transplantation in teenagers with CF [7]. The validity of this mathematical modeling as applied to the real clinical characteristics of these patients has been questioned [8]. The current lung allocation system in the United States is based upon disease severity, with the sicker patients receiving a higher priority score than those patients more stable.…”

Section: Indicationsmentioning

confidence: 99%

Pediatric Lung Transplantation

Huddleston

2010

Curr Treat Options Cardio Med

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Lung transplantation in children is an effective treatment for end-stage pulmonary disease after all medical therapy has failed. It requires a huge investment in resources and absolute commitment on the part of the parents and patients. In spite of all these efforts and expense, the results with pediatric lung transplantation are the worst of all solid organ transplants. Much lies ahead to overcome the obstacles faced to improve this therapy.

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“…Thus, it is now standard care to warm patients during surgery. Lung transplantation has been performed successfully in a significant number of patients and has become an established therapeutic option for patients with end-stage lung disease [5,6]. Single lung transplantation (SLT) can be performed without cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO) using one lung ventilation.…”

Section: Introductionmentioning

confidence: 99%