2018
DOI: 10.3904/kjim.2016.288
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Update of aristolochic acid nephropathy in Korea

Abstract: Background/AimsThe true incidence of aristolochic acid nephropathy (AAN) is thought to be underestimated because numerous ingredients known or suspected to contain aristolochic acid (AA) are used in traditional medicine in Korea.MethodsWe collected data on cases of AAN since 1996 via a database in Korea. We evaluated the year of AAN development, route to obtaining AA-containing herbal medicine, gender, reason for taking AA-containing herbal medicine, clinical manifestations, histological findings, phytochemica… Show more

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Cited by 20 publications
(21 citation statements)
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“…Generally, Aristolochia and one of its chief components aristolochic acid have been known for its carcinogenic, and nephrotoxic effects for a very long time ( Michael et al., 2009 ). Recently, several toxicological risks associated with a history of using herbal medicines containing aristolochic acid amongst cancer patients have been reported ( Aydin et al., 2017 ; Ban et al., 2018 ; Chen et al., 2018 ; Hoang et al., 2016 ; Hung et al., 2016 ; Kanaan et al., 2016 ; Popovska-Jankovic et al., 2016 ; Xiong et al., 2018 ; Zhong et al., 2017 ). Despite the reported cases on the use of herbs containing aristolochic acid around the world, a similar effect associated with the use of Aristolochia spp has yet to be reported in Nigeria.…”
Section: Resultsmentioning
confidence: 99%
“…Generally, Aristolochia and one of its chief components aristolochic acid have been known for its carcinogenic, and nephrotoxic effects for a very long time ( Michael et al., 2009 ). Recently, several toxicological risks associated with a history of using herbal medicines containing aristolochic acid amongst cancer patients have been reported ( Aydin et al., 2017 ; Ban et al., 2018 ; Chen et al., 2018 ; Hoang et al., 2016 ; Hung et al., 2016 ; Kanaan et al., 2016 ; Popovska-Jankovic et al., 2016 ; Xiong et al., 2018 ; Zhong et al., 2017 ). Despite the reported cases on the use of herbs containing aristolochic acid around the world, a similar effect associated with the use of Aristolochia spp has yet to be reported in Nigeria.…”
Section: Resultsmentioning
confidence: 99%
“…It is responsible for two serious renal diseases, AAN and BEN, both of which are associated with the development of upper urothelial cancer [ 9 , 10 , 11 , 12 , 13 , 15 , 16 , 17 ]. Despite the known carcinogenic properties of AA [ 2 , 3 , 4 , 5 , 6 , 7 ], Aristolochiaceae species are still used in traditional herbal medicine, particularly in Asia, where potentially millions of people are exposed to the nephrotoxic and carcinogenic effects of AA [ 11 , 39 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ]. While AAI, the major component of the plant extract, has been identified as a crucial factor for the development of UUC by inducing specific A:T→T:A transversion mutations in the DNA of patients suffering from AAN and BEN [ 4 , 13 , 38 , 40 , 42 ], the effects of the second major component, AAII, remain to better understood.…”
Section: Discussionmentioning
confidence: 99%
“…Long-term ingestion of herbal formula known or suspected to contain AAs is one of the prominent risk factors for developing AAN (Jia et al, 2005; Vervaet et al, 2017). Although the sale and use of AA-containing products are banned or restricted in most of the countries (Krell and Stebbing, 2013), AAN induced by numerous herbal remedies and products are still reported from all over the world (Lord et al, 1999; Yang et al, 2006; Debelle et al, 2008; Shaohua et al, 2010; Wu et al, 2012; Vaclavik et al, 2014; Ban et al, 2018).…”
Section: Aristolochic Acid-induced Adverse Reactionsmentioning
confidence: 99%