Update of mortality and cancer incidence in the Australian petroleum industry cohort

Gun, Richard Townsend; Pratt, Nicole; Ryan, Philip; Roder, David

doi:10.1136/oem.2005.023796

Cited by 64 publications

(94 citation statements)

References 24 publications

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“…Numerous mortality and incidence studies assessing this association have been performed mainly in benzene-exposed workers from the production of natural rubber film [139][140][141][142], shoe-producing industry [143,144] and the petroleum industry [19,20,[145][146][147][148][149][150][151][152][153][154][155][156][157], but other industries and occupations have also been examined [90,[158][159][160]. Table 3 provides an overview of studies that includes estimates of the quantitative risk of benzene exposure.…”

Section: Leukemiamentioning

confidence: 99%

Effects Of Benzene on Human Hematopoiesis

Kirkeleit¹,

Riise²,

Gjertsen³

et al. 2008

TOHJ

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Benzene, an aromatic hydrocarbon that is a natural component of crude oil and natural gas, is toxic to the blood and blood-forming organs. Epidemiological studies have established an association between benzene exposure and acute myeloid leukemia, and increasing evidence also indicates a possible association between benzene and multiple myeloma. A specific benzene-associated myelodysplastic syndrome has also been suggested. Chronic hematotoxic effects of benzene exposure, including reduced lymphocyte, neutrophil and platelet counts in peripheral blood, have been detected at occupational exposure below a level that had previously been considered not to cause any health effects. Whether these abnormalities represent bone marrow damage and/or initial events in the development of a true neoplastic disease is not known. Together with a reported nonlinear relationship between benzene exposure and the level of various metabolites, favoring production of biologically reactive quinones at exposure below 1 part per million, these observations suggest that benzene even at low exposure levels may contribute to the risk of acute myeloid leukemia or myelodysplastic syndrome, especially among genetically susceptible individuals.

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Section: Leukemiamentioning

confidence: 99%

Effects Of Benzene on Human Hematopoiesis

Kirkeleit¹,

Riise²,

Gjertsen³

et al. 2008

TOHJ

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“…Occupational epidemiological studies of workers at petrochemical and refinery plants indicate that exposure to benzene has a dose-response relationship with the risk for acute non-lymphocytic/acute myelogenous leukemia (Bloemen et al, 2004;Gun et al, 2006;Kirkeleit et al, 2008), exposure to vinyl chloride is associated with a substantial excess of angiosarcoma of the liver (Mundt et al, 2000;Ward et al, 2001), and exposure to butadiene is associated with an increased risk of non-Hodgkin lymphoma (Divine and Hartman, 2001). Two case-control studies from Taiwan indicated that living close to petrochemical industries may increase the risk of leukemia, especially in young people (Yu et al, 2006;Weng et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Excess Lifetime Cancer Risk Assessment of Volatile Organic Compounds Emitted from a Petrochemical Industrial Complex

Chen

Lin

Lai

et al. 2016

Aerosol Air Qual. Res.

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A health risk assessment for the Lin-Yuan Petrochemical Industrial Complex (LYPIC) in southern Taiwan was conducted in this study. The main aims of the study were to develop an emission inventory for the 21 processing plants in the LYPIC, conduct hazard identification based on the emission inventory, perform an exposure assessment by applying air dispersion modeling to obtain the annual average concentration of hazardous air pollutants near the LYPIC, and estimate the lifetime risk of cancer associated with volatile organic compound exposure for residents living in the vicinity of the LYPIC. Comparing with the reported monitoring data from several petrochemical and refinery plants in the world, the estimated exposure concentrations in this study were within reasonable range. The results of cancer risk assessment showed that the cumulative excess lifetime cancer risk (ELCR) at four representative residential sites surrounding the LYPIC were in the range of 9.3 × 10 -5 to 1.7 × 10 -4. From a risk management perspective, in order to protect human health, greater emphasis on the reduction of emissions of benzene, 1,3-butadiene, acrylonitrile, and vinyl chloride is recommended. This study provides a feasible risk assessment procedure to identify the key carcinogenic chemicals emitted from a petrochemical industrial complex.

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“…cancer forms, such as mesothelioma, hematopoietic cancers, malignant melanoma, cancer of the lung, and cancer of the prostate (3)(4)(5)(6)(7). Based on this, our attention was primarily directed towards cancer of the lung, pleura, prostate, melanoma of the skin, leukemia, and multiple myeloma.…”

mentioning

confidence: 99%

“…Furthermore, the association between the inhalation of asbestos fibers and cancer of the pleura has been well documented. Both lung cancer and cancer of the bladder can be caused by combustion products present in the work atmosphere, even if the most common cause is smoking (3)(4)(5). Additionally, leisure time on the platform may differ from life on the mainland with its 24-hour abundance of warm dishes, regulation of alcohol consumption, and low tobacco retail prices (8).…”

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confidence: 99%