Update of the EPTN atlas for CT- and MR-based contouring in Neuro-Oncology

Eekers, Daniëlle; Perri, Dario Di; Roelofs, Erik; Postma, Alida A.; Dijkstra, Jeanette; Ajithkumar, Thankamma; Alapetite, Claire; Blomstrand, Malin; Burnet, N.G.; Calugaru, Valentin; Compter, Inge; Coremans, I.; Harrabi, Semi; Iannalfi, Alberto; Klaver, Y.L.B.; Lambrecht, Maarten; Romero, Alejandra Méndez; Paulsen, Frank; Timmermann, Beate; Vítek, Pavel; Weide, H. L. van der; Whitfield, Gillian A; Nyström, Petra Witt; Zindler, Jaap; Ruysscher, Dirk De; Langendijk, Johannes A.; Weber, Damien Charles; Troost, Esther G.C.

doi:10.1016/j.radonc.2021.05.013

Cited by 40 publications

(19 citation statements)

References 35 publications

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“…1D). This was compared against conventional EYEPLAN treatment planning and the consensus guidelines for CT and MR atlas-based delineation in Neuro-Oncology recently proposed by the European Particle Therapy Network (EPTN) [26].…”

Section: Comparative Study On Tumour Volume Definition and Fovea Posi...mentioning

confidence: 99%

MRI and FUNDUS image fusion for improved ocular biometry in Ocular Proton Therapy

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Pica

Antonioli

et al. 2022

Radiotherapy and Oncology

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Section: Comparative Study On Tumour Volume Definition and Fovea Posi...mentioning

confidence: 99%

MRI and FUNDUS image fusion for improved ocular biometry in Ocular Proton Therapy

Via

Pica

Antonioli

et al. 2022

Radiotherapy and Oncology

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“…Recent studies have documented deleterious associations between radiation dose to brain substructures and neurocognitive score in both pediatric and adult patients ( Toussaint et al, 2019 ; Haldbo-Classen et al, 2020 ; Acharya et al, 2021 ; Eekers et al, 2021 ; Rodríguez de Dios et al, 2021 ). This is in line with the significant predictive power of radiation dose to the hippocampus, subventricular zone, and cerebellum in the available prediction models.…”

Section: Discussionmentioning

confidence: 99%

Prediction Models for Radiation-Induced Neurocognitive Decline in Adult Patients With Primary or Secondary Brain Tumors: A Systematic Review

et al. 2022

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PurposeAlthough an increasing body of literature suggests a relationship between brain irradiation and deterioration of neurocognitive function, it remains as the standard therapeutic and prophylactic modality in patients with brain tumors. This review was aimed to abstract and evaluate the prediction models for radiation-induced neurocognitive decline in patients with primary or secondary brain tumors.MethodsMEDLINE was searched on October 31, 2021 for publications containing relevant truncation and MeSH terms related to “radiotherapy,” “brain,” “prediction model,” and “neurocognitive impairments.” Risk of bias was assessed using the Prediction model Risk Of Bias ASsessment Tool.ResultsOf 3,580 studies reviewed, 23 prediction models were identified. Age, tumor location, education level, baseline neurocognitive score, and radiation dose to the hippocampus were the most common predictors in the models. The Hopkins verbal learning (n = 7) and the trail making tests (n = 4) were the most frequent outcome assessment tools. All studies used regression (n = 14 linear, n = 8 logistic, and n = 4 Cox) as machine learning method. All models were judged to have a high risk of bias mainly due to issues in the analysis.ConclusionExisting models have limited quality and are at high risk of bias. Following recommendations are outlined in this review to improve future models: developing cognitive assessment instruments taking into account the peculiar traits of the different brain tumors and radiation modalities; adherence to model development and validation guidelines; careful choice of candidate predictors according to the literature and domain expert consensus; and considering radiation dose to brain substructures as they can provide important information on specific neurocognitive impairments.

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“…In future developments, an atlas can be created on co-registered CT and MR images. Additionally, the EPTN consensus has recently been updated and now includes additional OARs [35]. Therefore, further development of our automated atlas is warranted.…”

Section: Discussionmentioning

confidence: 99%

Development and evaluation of an automated EPTN-consensus based organ at risk atlas in the brain on MRI

Crouzen

Petoukhova

Wiggenraad

et al. 2022

Radiotherapy and Oncology

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Update of the EPTN atlas for CT- and MR-based contouring in Neuro-Oncology

Cited by 40 publications

References 35 publications

MRI and FUNDUS image fusion for improved ocular biometry in Ocular Proton Therapy

MRI and FUNDUS image fusion for improved ocular biometry in Ocular Proton Therapy

Prediction Models for Radiation-Induced Neurocognitive Decline in Adult Patients With Primary or Secondary Brain Tumors: A Systematic Review

Development and evaluation of an automated EPTN-consensus based organ at risk atlas in the brain on MRI

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