Update on Anticonvulsant Therapy in the Emergent Small Animal Patient

Heller, Heidi Barnes

doi:10.1016/j.cvsm.2020.07.009

Cited by 1 publication

(2 citation statements)

References 39 publications

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“…The prevalence of PIE in cats with recurrent epileptic seizures has been reported to be in the range of 22%-75%, 1,2,7,9-12 with the majority having seizure onset at 1-5 years. 5,13,14 The use of several antiepileptic drugs for cats with PIE has been reported, [15][16][17] with phenobarbital (PB) considered the most effective. 18 An important disadvantage of PB is that it can only be given orally by owners, with the recommendation of medicating cats twice daily.…”

Section: Introductionmentioning

confidence: 99%

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Once-a-day oral treatment with phenobarbital in cats with presumptive idiopathic epilepsy

Mojarradi,

De Decker,

Van Meervenne

2023

Journal of Feline Medicine and Surgery

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Objectives Phenobarbital (PB) q12h is the most common treatment recommendation for cats with recurrent epileptic seizures. Medicating cats may be challenging and result in decreased quality of life for both cat and owner. The aim of this retrospective study was to evaluate treatment with oral PB q24h in cats with presumptive idiopathic epilepsy. Methods Nine cats with presumptive idiopathic epilepsy, receiving oral PB q24h, were included in a retrospective descriptive study. Results Seizure remission was achieved in 88% (8/9) of the cats and good seizure control in 12% (1/9) of the cats, treated with a mean dose of oral PB of 2.6 mg/kg q24h (range 1.4–3.8 mg/kg). No cats required an increase of their PB frequency at any time during a mean follow-up period of 3.5 years (range 1.1–8.0 years). No cats displayed side effects or issues with compliance at the last recorded follow-up. Conclusions and relevance Once-a-day administration of PB for feline epilepsy was safe and resulted in satisfactory seizure control for the nine cats included in this study. The results of this study justify exploring this topic further in larger prospective studies.

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Section: Introductionmentioning

confidence: 99%

“…The use of several antiepileptic drugs for cats with PIE has been reported, 15 – 17 with phenobarbital (PB) considered the most effective. 18 An important disadvantage of PB is that it can only be given orally by owners, with the recommendation of medicating cats twice daily.…”

Section: Introductionmentioning

confidence: 99%