Update on Association of Fried's Frailty Score and Sarcopenia After Left Ventricular Assist Device Implantation

Dharmavaram, Gourisree; Lin, Andrew H; Hannsun, G.; Nguyễn, Vân Hà; Sirignano, M.; Mendenhall, M.; Adler, Eric; Pretorius, Victor; Tran, Hao

doi:10.1016/j.healun.2022.01.1397

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that the small sample size may have reduced the statistical power to detect the differences in the readmission rates. In a previous study, statistical significance was observed between the frail and non‐frail groups, although the outcome was reported as a composite of all‐cause mortality and 30‐day re‐admission 31 . Although limited by the small sample size, another study reported opposing results 32 .…”

Section: Discussionmentioning

confidence: 94%

“…In a previous study, statistical significance was observed between the frail and non‐frail groups, although the outcome was reported as a composite of all‐cause mortality and 30‐day re‐admission. 31 Although limited by the small sample size, another study reported opposing results. 32 The investigators used multiple frailty parameters or surrogates and reported that frailty status according to hand grip strength were less likely to be re‐admitted within 30 days of discharge after LVAD implantation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The prognostic value of clinical frailty scale and outcomes in older patients undergoing left ventricular assist device implantation

et al. 2022

View full text Add to dashboard Cite

Objectives Heart failure impacts patients’ functional capabilities, ultimately leading to frailty. The use of a left ventricular assist device (LVAD) is acceptable as both destination therapy and bridge to transplant in heart failure management. We aim to evaluate the prognostic value of the Clinical Frailty Scale (CFS) on outcomes in older patients undergoing implantation of LVAD. Methods We conducted a retrospective chart review of patients ≥ 60 years old that underwent LVAD implantation at our medical center from May 1, 2018, to October 30, 2020. CFS was retrospectively assigned before LVAD placement and CFS scores > 4 was considered frail. Kaplan–Meier curves and Cox regression were used to analyze 1‐year survival estimates. Results Forty percent of the cohort was classified as frail according to CFS. Thirty‐day re‐admission rates were comparable between frail and non‐frail patients (46% vs 35%; P = 0.419). 1‐year survival was lower in the frail vs non‐frail group (log rank, P = 0.017). On Cox analysis, only frailty was associated with 1‐year post‐intervention mortality (hazard ratio [HR] = 5.64, 95% confidence interval [CI] = 1.131–28.212; P = 0.035). Conclusions CFS‐defined frailty was associated with increased risk of 1‐year mortality after LVAD implantation. CFS may be a valuable tool in the frailty assessment for risk stratification of patients undergoing LVAD implantation. Multicenter studies are required to validate these findings.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%