Update on botulinum neurotoxin use in aesthetic dermatology

Ibrahim, Omer; Keller, Emily C; Arndt, Kenneth A.

doi:10.12788/j.sder.0115

Cited by 6 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Awareness regarding the innovation and science behind different agents, along with the underlying anatomy, enables the injector to cater to patients’ needs with a variety of treatment options. 32 Individualized assessment, personalized appropriate dosing, selection of the exact injection site, and clinical follow-up are critical to achieving optimal results. 33…”

Section: Discussionmentioning

confidence: 99%

“…Awareness regarding the innovation and science behind different agents, along with the underlying anatomy, enables the injector to cater to patients' needs with a variety of treatment options. 32 Individualized assessment, personalized appropriate dosing, selection of the exact injection site, and clinical followup are critical to achieving optimal results. 33 An expert panel recently published on the changes in patient population, similarities of and differences between the FDA-approved BoNT-A agents, evolving use of BoNT-A throughout the face, and how the approval of a new BoNT-A can affect clinical practice.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Tailored Indications for Different Neurotoxins

Sezgin

2023

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

Background: Minimally invasive procedures have become increasingly popular because they require minimal downtime and are effective for achieving a more youthful appearance. All U.S. Food and Drug Administration–approved neurotoxins are indicated for achieving similar effects, even though they are different in regard to structure, manufacturing technique, and storage requirements. It is agreed upon that each neurotoxin is unique and therefore not interchangeable. The aim of the author is to provide an approach for choosing the optimal toxin in different indications regarding the area of treatment, the age and characteristics of the patient, potential risks, and ultimate goals. Methods: As the country that the author practices carries onabotulinum (ONA), prabotulinum (PRA), and abobotulinum (ABO) toxin type-A, one of these three toxins was preferred for each category. ABO toxins were preferred in wide areas due to the broader action halo. Typical examples include hyperhidrosis treatment, wide forehead area, and calf slimming. In areas where very precise and targeted treatment is required, PRA and ONA toxins were preferred to limit potential side effects due to wider diffusion. First-time patients were typically treated with PRA toxins for a softer trial periods where as “repeat” patients were successfully treated with ABO toxins. Results: No toxin is superior to the other in terms of producing effects. Yet, small differences in their properties can allow the plastic surgeon to cater to each patient’s needs while yielding the most optimal results. Conclusions: This study is meant to serve as a guideline for choosing the ideal toxin in different patient settings and indications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tailored Indications for Different Neurotoxins

Sezgin

2023

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

show abstract

“…BoNTs are approved by FDA and other regulatory agencies for the treatment of a diverse group of disorders including muscle over-activity (MoA) from various causes, neuro-secretory disorders and pain conditions [ 1 , 2 , 3 , 4 , 5 , 6 ]. The list of approved, proposed and investigational uses of BoNTs continues to expand at a rapid pace ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Guidance for Botulinum Neurotoxin Chemodenervation Procedures

Alter

Karp

2017

Toxins

View full text Add to dashboard Cite

Injections of botulinum neurotoxins (BoNTs) are prescribed by clinicians for a variety of disorders that cause over-activity of muscles; glands; pain and other structures. Accurately targeting the structure for injection is one of the principle goals when performing BoNTs procedures. Traditionally; injections have been guided by anatomic landmarks; palpation; range of motion; electromyography or electrical stimulation. Ultrasound (US) based imaging based guidance overcomes some of the limitations of traditional techniques. US and/or US combined with traditional guidance techniques is utilized and or recommended by many expert clinicians; authors and in practice guidelines by professional academies. This article reviews the advantages and disadvantages of available guidance techniques including US as well as technical aspects of US guidance and a focused literature review related to US guidance for chemodenervation procedures including BoNTs injection.

show abstract

Inhibition of regulated cell death by cell-penetrating peptides

Krautwald

Dewitz

Fändrich

et al. 2016

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Development of the means to efficiently and continuously renew missing and non-functional proteins in diseased cells remains a major goal in modern molecular medicine. While gene therapy has the potential to achieve this, substantial obstacles must be overcome before clinical application can be considered. A promising alternative approach is the direct delivery of non-permeant active biomolecules, such as oligonucleotides, peptides and proteins, to the affected cells with the purpose of ameliorating an advanced disease process. In addition to receptor-mediated endocytosis, cell-penetrating peptides are widely used as vectors for rapid translocation of conjugated molecules across cell membranes into intracellular compartments and the delivery of these therapeutic molecules is generally referred to as novel prospective protein therapy. As a broad coverage of the enormous amount of published data in this field is unrewarding, this review will provide a brief, focused overview of the technology and a summary of recent studies of the most commonly used protein transduction domains and their potential as therapeutic agents for the treatment of cellular damage and the prevention of regulated cell death.

show abstract

Update on botulinum neurotoxin use in aesthetic dermatology

Cited by 6 publications

References 31 publications

Tailored Indications for Different Neurotoxins

Tailored Indications for Different Neurotoxins

Ultrasound Guidance for Botulinum Neurotoxin Chemodenervation Procedures

Inhibition of regulated cell death by cell-penetrating peptides

Contact Info

Product

Resources

About