Update on chronic intestinal pseudo-obstruction

Zenzeri, Letizia; Tambucci, Renato; Quitadamo, Paolo; Giorgio, Valentina; Giorgio, Roberto De; Nardo, Giovanni Di

doi:10.1097/mog.0000000000000630

Cited by 35 publications

(48 citation statements)

References 67 publications

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“…19 The manifestations of intestinal obstruction symptoms and/or bladder movement disorders highly suggest the existence of CIPO. 20 This patient had various autonomic dysfunctions such as profuse sweating, dysuria, and difficulty defecating, which are consistent with the symptoms that are mentioned above.…”

Section: Discussionsupporting

confidence: 83%

Anti-CV2/CRMP5 antibody-positive paraneoplastic neurological syndromes with chronic intestinal pseudo-obstruction in a small-cell lung cancer patient: a case report and literature review

et al. 2020

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Patients with anti-CV2/collapsin response mediator protein (CRMP)5 antibodies present with more frequent chorea, cerebellar ataxia, uveo/retinal symptoms, and Lambert–Eaton myasthenic syndrome or myasthenia gravis. Chronic intestinal pseudo-obstruction (CIPO) is an intestinal motility dysfunction disease dysmotility that is caused by a neuromuscular disease with recurrent or persistent intestinal obstruction in the absence of mechanical obstruction. We report the case of a patient with CRMP5 antibody-positive paraneoplastic neurological syndrome (PNS) that is associated with autonomic dysfunction (presenting most remarkably as CIPO). CIPO is one of the rarest forms of PNS. Some PNS patients who are positive for anti-CV2/CRMP5 antibodies may have fatal complications such as CIPO. To detect if PNS patients are at risk for CIPO, a timely diagnosis and appropriate treatment are required.

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Section: Discussionsupporting

confidence: 83%

Anti-CV2/CRMP5 antibody-positive paraneoplastic neurological syndromes with chronic intestinal pseudo-obstruction in a small-cell lung cancer patient: a case report and literature review

et al. 2020

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“…Diagnostic criteria include absence of mechanical obstruction and histological examination of all intestinal layers [ 8 ]. To exclude mechanical bowel obstruction plain abdominal radiography, CT, magnetic resonance imaging or, in some cases, endoscopic examination might be used [ 7 , 9 ]. Histopathological examination reveals degenerative changes of myocytes, fibrosis and partial or complete defects in the intestinal lamina muscularis propia [ 6 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Rare case of visceral myopathy

Dreyer

Pankratjevaitė

Jančiauskas

et al. 2021

Journal of Surgical Case Reports

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Visceral myopathy is a rare bowel disease affecting peristalsis and causing pseudo-obstruction. There is no specific treatment for chronic intestinal pseudo-obstruction caused by visceral myopathy. We report a case of a 30-year-old woman with visceral myopathy who, due to unsuccessful conservative treatment, underwent surgery. However, few surgeries did not give the desired result and the patient still suffers from chronic constipation, abdominal distension and pain. The diagnosis of visceral myopathy is complicated. Neither conservative nor surgical treatment of visceral myopathy is associated with good results.

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“…FMT is commonly used for the treatment of recurrent pseudomembranous colitis caused by toxinproducing Clostridium difficile (161). Moreover, FMT was also used to alleviate chronic intestinal pseudo-obstructive syndrome (CIPO) mimicking mechanical intestinal obstruction (162,163) or the small intestinal bacterial overgrowth syndrome (SIBO). SIBO is a gastrointestinal disorder diagnosed as an excessive and/ or abnormal bacterial colonization in the small intestine (more than 10 5 colony-forming units of bacteria per mL of jejunal aspirate) associated with various metabolic disorders and serious malnutrition found also in patients with AN (68,163) who suffer from delayed gastric emptying and constipation (164,165).…”

Section: The Gut Microbiome In An and Bnmentioning

confidence: 99%

Current Aspects of the Role of Autoantibodies Directed Against Appetite-Regulating Hormones and the Gut Microbiome in Eating Disorders

et al. 2021

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The equilibrium and reciprocal actions among appetite-stimulating (orexigenic) and appetite-suppressing (anorexigenic) signals synthesized in the gut, brain, microbiome and adipose tissue (AT), seems to play a pivotal role in the regulation of food intake and feeding behavior, anxiety, and depression. A dysregulation of mechanisms controlling the energy balance may result in eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). AN is a psychiatric disease defined by chronic self-induced extreme dietary restriction leading to an extremely low body weight and adiposity. BN is defined as out-of-control binge eating, which is compensated by self-induced vomiting, fasting, or excessive exercise. Certain gut microbiota-related compounds, like bacterial chaperone protein Escherichia coli caseinolytic protease B (ClpB) and food-derived antigens were recently described to trigger the production of autoantibodies cross-reacting with appetite-regulating hormones and neurotransmitters. Gut microbiome may be a potential manipulator for AT and energy homeostasis. Thus, the regulation of appetite, emotion, mood, and nutritional status is also under the control of neuroimmunoendocrine mechanisms by secretion of autoantibodies directed against neuropeptides, neuroactive metabolites, and peptides. In AN and BN, altered cholinergic, dopaminergic, adrenergic, and serotonergic relays may lead to abnormal AT, gut, and brain hormone secretion. The present review summarizes updated knowledge regarding the gut dysbiosis, gut-barrier permeability, short-chain fatty acids (SCFA), fecal microbial transplantation (FMT), blood-brain barrier permeability, and autoantibodies within the ghrelin and melanocortin systems in eating disorders. We expect that the new knowledge may be used for the development of a novel preventive and therapeutic approach for treatment of AN and BN.

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Update on chronic intestinal pseudo-obstruction

Cited by 35 publications

References 67 publications

Anti-CV2/CRMP5 antibody-positive paraneoplastic neurological syndromes with chronic intestinal pseudo-obstruction in a small-cell lung cancer patient: a case report and literature review

Anti-CV2/CRMP5 antibody-positive paraneoplastic neurological syndromes with chronic intestinal pseudo-obstruction in a small-cell lung cancer patient: a case report and literature review

Rare case of visceral myopathy

Current Aspects of the Role of Autoantibodies Directed Against Appetite-Regulating Hormones and the Gut Microbiome in Eating Disorders

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