Update on clinical research for food allergy treatment

Fowler, Joshua K.; Lieberman, Jay

doi:10.3389/falgy.2023.1154541

Cited by 6 publications

(3 citation statements)

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“…The treatment landscape for food allergy is rapidly evolving; therapeutic strategies under investigation for allergen immunotherapy include subcutaneous immunotherapy (SCIT), sublingual immunotherapy (SLIT), and epicutaneous immunotherapy (EPIT) (78). Several biologics and small molecules in addition to omalizumab, including BTK inhibitor (acalabrutinib and remibrutinib), anti-IL-33 antibody (etokimab), and anti-TSLP antibody (tezepelumab) are being studied to target different pathways in the allergic response (77, [79][80][81]. Clinical trials are also exploring the combination of treatments, for example anti-IgE in combination with OIT, to improve the safety and time to reach maintenance dose (69).…”

Section: Investigational Treatmentsmentioning

confidence: 99%

The role of pediatricians in the diagnosis and management of IgE-mediated food allergy: a review

Gupta,

Epstein,

Wood

2024

Front. Pediatr.

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ImportanceFood allergy can often cause a significant burden on patients, families, and healthcare systems. The complexity of food allergy management requires a multidisciplinary approach involving different types of healthcare providers, including allergists, dieticians, psychologists, nurses, family practitioners and, of particular relevance for this article, pediatric primary caretakers. Pediatricians may be the first-line healthcare providers for food allergy: strategies for management and guideline adherence have been highlighted.ObservationsThis review article summarizes the up-to-date recommendations on the role of pediatricians in the diagnosis, management, and prevention of IgE-mediated food allergy. Early introduction of allergenic foods like peanut is known to be of importance to reduce the development of peanut allergy in infants, and pediatricians are essential for educating and supporting parents in this decision. In scenarios of limited allergist availability, as is often the case among rural, Medicaid and minority populations, pediatricians can assist in the evaluation and management of food allergy, and provide action plans, education and counselling for patients and families.Conclusions and relevancePediatric primary caretakers play a key role in the diagnosis, management, and prevention of IgE-mediated food allergy. As more diagnostic tools and therapies in food allergy become available, the need for a multidisciplinary team is paramount to optimize patient care.

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Section: Investigational Treatmentsmentioning

confidence: 99%

The role of pediatricians in the diagnosis and management of IgE-mediated food allergy: a review

Gupta,

Epstein,

Wood

2024

Front. Pediatr.

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“…Several clinical trials and research studies have been conducted to evaluate the safety and efficacy of EPIT for various allergens, including pollen, dust mites, and food allergens. These studies have shown promising results in terms of reducing allergic symptoms and improving patients' quality of life [102,103].As a result, regarding the regulatory status, EPIT has been approved for certain allergens by regulatory authorities in some regions but, the availability of EPIT may vary depending on the specific allergen and the region. EPIT is not suitable for all allergens and conditions.…”

Section: Clinical Trials and Researchmentioning

confidence: 99%

Allergen Specific Immunotherapy (AIT)

Thiago Luiz Bandeira,

Isabela Mansur Bandeira,

Juliana CM Vasconcellos

et al. 2023

World J. Adv. Res. Rev.

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Allergic/atopic patients do not develop immune tolerance to certain substances in the environment which are harmless to non-allergic individuals. These patients are hypersensitive to these substances-allergens. Specific Allergen Immunotherapy (AIT), also known as Allergy Shots or Desensitization, is a therapeutic approach used to treat allergic conditions, such as allergic rhinitis, allergic asthma, and insect sting allergies. The primary goal of AIT is to reduce the allergic response to specific allergens by gradually exposing the patient to increasing doses of the allergen over time. This exposure helps the immune system build tolerance to the allergen, leading to a decrease in allergic symptoms and a long-term improvement in clinical outcomes. Research has confirmed the long-term clinical efficacy of AIT, and its ability to induce antigen-specific tolerance. In this review, we aim to discuss the immunological mechanisms involved in different types of AITs, their efficacy and safety.

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“…Without a doubt, great strides have been made in not only understanding the immunology of food allergy but also in potential therapeutic options for patients. While at this time there is only one FDA approved therapeutic for peanut allergy, a number of immunotherapeutic approaches are currently under investigation—including different routes of immunotherapy (oral, sublingual and epicutaneous), immunotherapy with modified recombinant proteins, and use of biologics (with and without immunotherapy) ( 2 ).…”

mentioning

confidence: 99%