Update on Diagnosis and Treatment of Diabetic Retinopathy: A Consensus Guideline of the Working Group of Ocular Health (Spanish Society of Diabetes and Spanish Vitreous and Retina Society)

Corcóstegui, Borja; Durán, Santiago; González-Albarrán, María Olga; Hernández, Cristina; Ruiz-Moreno, José M.; Salvador, Javier; Udaondo, Patricia; Simó, Rafael

doi:10.1155/2017/8234186

Cited by 66 publications

(44 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diabetic retinopathy (DR) results from microvascular retinal damage, which may lead to diabetic retinal ischaemia, increased vascular permeability, retinal neovascularization and diabetic macular oedema (DMO). Diabetic retinopathy (DR) can be classified as non‐proliferative (NPDR) and proliferative DR (PDR), where NPDR is divided into mild, moderate and severe NPDR (Corcostegui et al ). The main risk factors for DR are type and duration of diabetes, hyperglycaemia and elevated blood pressure (BP) (Yau et al ).…”

Section: Introductionmentioning

confidence: 99%

Evidence and indications for systemic treatment in diabetic retinopathy: a systematic review

Elkjaer

Lynge

Grauslund

2020

Acta Ophthalmologica

View full text Add to dashboard Cite

Eye screening is mandatory in diabetes, but treatment is only indicated at the sight-threatening stages of diabetic retinopathy (DR). Treatments include intravitreal injections, laser photocoagulation and vitrectomy, which are all invasive options. In order to prevent or delay DR, it is important to investigate earlier, non-invasive managements prior to sight-threatening DR. The aim of this study is to evaluate the effect of systemic treatment on incident and progressive DR. The search in this systematic review was performed in PubMed and Embase using the keywords 'diabetic retinopathy' AND 'systemic therapy'. Two independent researchers identified 619 studies; 26 duplicates were removed, 579 articles were excluded based on title and abstract, and six were removed after full-text assessment. Five articles were added from reference screening, resolving in a total of 13 eligible articles. These were quality-assessed using the Cochrane Risk of Bias tool. Twelve randomized control trials and one follow-up study were included. Intensive glycaemic control (IGC), antihypertensive and lipid-lowering treatments were some of the main interventions tested in the studies. Three studies found statistically significant reduction of progression of DR by IGC, three by antihypertensive, and two by the lipid-lowering drug fenofibrate. Systemic intervention appears important in different stages of DR. While IGC seems effective in relation to incident and progressive DR, antihypertensive treatments may be valuable in the early stages of DR, as opposed to fenofibrate, which could benefit at a later stage.

show abstract

Section: Introductionmentioning

confidence: 99%

Evidence and indications for systemic treatment in diabetic retinopathy: a systematic review

Elkjaer

Lynge

Grauslund

2020

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…diabetes. Clinically, diabetic retinopathy is classified as nonproliferative (NPDR) and proliferative (PDR) stages [8]. The NPDR is the early stage of the disease symptoms will be mild, moderate, or sever.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Diabetic Retinopathy and Associated Factors among Type 2 Diabetes Patients at Tikur Anbessa Hospital, Ethiopia

Shibru¹,

Aga²,

Boka³

2019

J Diabetes Metab

View full text Add to dashboard Cite

Background: Diabetic retinopathy is a complication of type 2 diabetes resulting from long-term accumulated damage to retinal blood vessels. It is one of the leading causes of preventable blindness in adults with type 2 diabetes. The purpose of this study was to assess the prevalence of diabetic retinopathy and associated factors among type 2 diabetes patients visiting Tikur Anbessa Hospital in Addis Ababa, Ethiopia. Methods: A cross-sectional study was conducted from March to April 2018. Data was collected using semi-structured questionnaire and direct eye examination with Topcon Retinal Camera. Data was analyzed using SPSS for Windows version 22. Logistic regression models were used to identify predictors of diabetic retinopathy. Statistical significance was determined using odds ratio with 95% confidence interval. Result: A total of 191 type 2 diabetes patients, mean age of 57 ± 10.1 years, participated in this study. From this, 98 (51.3%) had diabetic retinopathy. Multiple logistic regression model revealed that male were about 11 times (AOR=11.248, 95%CI=1.816, 69.689) more likely to have diabetic retinopathy. Participants who visited diabetes clinic every month were about 37 times (AOR=0.027, 95%CI=0.003, 0.0253), those with HbA1c ≤ 7% were 10 times (AOR=0.099, 95%CI=0.020, 0.485), and those without comorbid hypertension were 31.3 times (AOR=0.032, 95%CI=0.006, 0.167) less likely to have diabetic retinopathy. There was a 1.13 times increase in prevalence of diabetic retinopathy for a 1 year increase in the type 2 diabetes duration (AOR=1.126, 95%CI=1.022, 1.242). Conclusion: Our study showed the prevalence of diabetic retinopathy was 51.3%. Male sex, clinic visits every 6 months, longer duration of diabetes, HbA1c>7%, and comorbid hypertension were independently associated with diabetic retinopathy. Timely screening for diabetic retinopathy and continuous diabetes self-management education are warranted.

show abstract

“…Soon after Maiman in 1960 discovered the first ruby-based working laser, many types of gaseous, liquid, and solid materials were found applicable in a laser technique [ 5 ]. Concurrently, first experiments on medical laser application begun and only a couple of years after Maiman's discovery, ruby laser was studied in ophthalmology leading to an extensive use of modern laser devices in this branch of medicine [ 6 , 7 ]. Currently, medical laser devices are widely used not only in ophthalmology, but also in laryngology, dermatology, urology, oncology, and surgery, and the number of procedures performed with lasers continually grows.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Evaluation of Thulium Doped Fiber Laser in Pig Model of Liver Surgery

Janeczek

Świderski

Czerski

et al. 2018

BioMed Research International

View full text Add to dashboard Cite

Partial liver resection is a treatment of choice for liver tumors; the range of parenchyma excision varies from a small part of the tissue surrounding the neoplasm up to 70% of the organ. One of the major concerns during liver resection is blood loss. Thulium lasers which are characterized by the length of emission wave corresponding to a peak absorption of water create a new possibility of cutting tissues efficiently with minimal thermal damage and concurrently providing a good hemostasis control. The aim of our study was to evaluate an impact of liver transection with thulium doped fiber laser on an intraoperative bleeding and histopathological changes during postoperative period in swine model. Ten animals were subjected to open surgery partial liver resection and an incision of liver tissue with an all-fiber, diode-pumped, and continuous-wave Tm3+-doped fiber laser emitting 37.4 W of output power at ~1.94 μm wavelength. The macroscopic and histopathological evaluation was performed intraoperatively as well as 7 and 14 days after surgery. Macroscopically almost no bleeding was observed during surgery and no signs of bleeding were stated after 7 and 14 days. Histopathological analysis of the transection margin revealed a thermal damage area ranging in depth from 620.23 ± 23.82 μm on the day of surgery to 1817.70 ± 211.98 μm after 7 days. In the samples taken intraoperatively and after 7 days a superficial zone of carbonization was visibly separated from the deeper changes. After 14 days one 765.35 μm deep zone characterized by a granulation was present. In conclusion, thulium doped fiber laser is efficacious in cutting with a narrow zone of thermal injury and provides a good hemostasis during liver transection, thus being a potential tool for oncotic liver surgery.

show abstract

Update on Diagnosis and Treatment of Diabetic Retinopathy: A Consensus Guideline of the Working Group of Ocular Health (Spanish Society of Diabetes and Spanish Vitreous and Retina Society)

Cited by 66 publications

References 74 publications

Evidence and indications for systemic treatment in diabetic retinopathy: a systematic review

Evidence and indications for systemic treatment in diabetic retinopathy: a systematic review

Prevalence of Diabetic Retinopathy and Associated Factors among Type 2 Diabetes Patients at Tikur Anbessa Hospital, Ethiopia

Preliminary Evaluation of Thulium Doped Fiber Laser in Pig Model of Liver Surgery

Contact Info

Product

Resources

About