Update on Findings about Sudden Sensorineural Hearing Loss and Insight into Its Pathogenesis

Yamada, Satoshi; Kita, Junya; Shinmura, Daichi; Nakamura, Yuki; Sahara, Sosuke; Misawa, Kiyoshi; Nakanishi, Hiroshi

doi:10.3390/jcm11216387

Cited by 23 publications

(11 citation statements)

References 111 publications

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“…One possible mechanism is that SVD in the inner ear can lead to decreased blood flow and ischemia, which can damage the hair cells and neural structures responsible for hearing [ 17 ]. Another proposed mechanism is that SVD can cause inflammation and oxidative stress in the inner ear, leading to further damage to the hearing structures [ 18 ]. Studies have also suggested that SVD in the inner ear may be a manifestation of a more generalized vascular pathology that affects multiple organs, including the brain and heart [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Importance of small vessel disease as a possible cause of sudden sensorineural hearing loss

Yoon,

Lee,

Kong

et al. 2024

PLoS ONE

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Objective Vascular disease like small-vessel disease (SVD) is the most likely cause among the potential causes of Sudden sensorineural hearing loss (SSNHL). Understanding the relationship between SVD and SSNHL is crucial for developing effective prevention and treatment strategies. To confirm the relationship between SVD and SSNHL, the effect of SVD is confirmed by focusing on the duration and recurrence of SSNHL. Methods This article reports a retrospective observational study that investigated the relationship between SVD and SSNHL using the South Korea Health Insurance Review and Assessment Service (HIRA) database from 2010 to 2020. This retrospective observational study included 319,569 SSNHL patients between 2010 and 2020. Results Participant demographics were controlled using Propensity Score Matching. The hazard ratios (HR) for the effect of SVD on the duration of SSNHL were 1.045 for the group with SVD before the onset of SSNHL and 1.234 for the group with SVD after the onset of SSNHL. SVD was statistically significant for the recurrence of SSNHL, with an odds ratio of 1.312 in the group with SVD compared to the group without SVD. The HR for the period until a recurrence in the group with SVD was 1.062. Conclusions The study identified SVD as a possible cause of SSNHL and found that the duration of SSNHL increased only in the presence of SVD. SVD also affected the recurrence of SSNHL, with the recurrence rate being 1.312 times higher in the group with SVD.

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Section: Discussionmentioning

confidence: 99%

Importance of small vessel disease as a possible cause of sudden sensorineural hearing loss

Yoon,

Lee,

Kong

et al. 2024

PLoS ONE

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“…Prolonged TT was seen in diseases with reduced plasma fibrinogen, such as disseminated intravascular coagulation ( 12 ) and dysfibrinogenemia ( 13 ). A previous study has shown that dysfunction of inner ear microcirculation plays an important role in SSNHL ( 14 ); however, due to the lack of effective evidence-based evidence, the use of anticoagulants has not reached an international consensus ( 11 ). Labyrinthine hemorrhage has also been reported as a potential factor for SSNHL ( 3 ); meanwhile, oral anticoagulants may interfere with microcirculation in the inner ear by influencing the viscosity of the plasma ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Development and validation for multifactor prediction model of sudden sensorineural hearing loss

et al. 2023

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BackgroundSudden sensorineural hearing loss (SSNHL) is a global problem threatening human health. Early and rapid diagnosis contributes to effective treatment. However, there is a lack of effective SSNHL prediction models.MethodsA retrospective study of SSNHL patients from Fujian Geriatric Hospital (the development cohort with 77 participants) was conducted and data from First Hospital of Putian City (the validation cohort with 57 participants) from January 2018 to December 2021 were validated. Basic characteristics and the results of the conventional coagulation test (CCT) and the blood routine test (BRT) were then evaluated. Binary logistic regression was used to develop a prediction model to identify variables significantly associated with SSNHL, which were then included in the nomogram. The discrimination and calibration ability of the nomogram was evaluated by receiver operating characteristic (ROC), calibration plot, and decision curve analysis both in the development and validation cohorts. Delong’s test was used to calculate the difference in ROC curves between the two cohorts.ResultsThrombin time (TT), red blood cell (RBC), and granulocyte–lymphocyte ratio (GLR) were found to be associated with the diagnosis of SSNHL. A prediction nomogram was constructed using these three predictors. The AUC in the development and validation cohorts was 0.871 (95% CI: 0.789–0.953) and 0.759 (95% CI: 0.635–0.883), respectively. Delong’s test showed no significant difference in the ROC curves between the two groups (D = 1.482, p = 0.141).ConclusionIn this study, a multifactor prediction model for SSNHL was established and validated. The factors included in the model could be easily and quickly accessed, which could help physicians make early diagnosis and clinical treatment decisions.

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“…The incidence of SSHL is reported to be between 5 and 30 cases per 100,000 [ 38 ]. Although SSHL can occur after COVID-19 infection, the etiologic mechanism is still unclear [ 39 ]. As a future perspective, we suggest exploring the modifications of potential biomarkers associated with SSHL that can contribute to elucidating the potential biological mechanisms bridging sensory loss and COVID-19, after virus infection and after vaccine administration, aiming to explore a possible overlapping mechanism used by an immune response and consequent nervous damage.…”

Section: Discussionmentioning

confidence: 99%

Neurofilament Expression as a Biomarker of Post-COVID-19 Sudden Sensorineural Hearing Loss

et al. 2023

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Sudden sensorineural hearing loss (SSHL) affects a patient’s quality of life and requires rapid treatment. The etiology is viral, vascular, and autoimmune, even though, in most cases, it remains idiopathic SSHL. Since 2019, several different complications have been identified following COVID-19 infection. The post-COVID-19 ENT manifestations reported in the literature are sore throat, headache, pharyngeal erythema, nasal obstruction, rhinorrhea, upper respiratory tract infection, and tonsil enlargement. Cases of SSHL, vestibular neuronitis, and audio-vestibular disorders (such as tinnitus, dizziness, and vertigo) have also been reported, albeit in a smaller percentage of patients. We reported our experience of a case of post-COVID-19 SSHL in the absence of any other type of post-COVID symptoms or brain and internal auditory canal magnetic resonance imaging and magnetic resonance angiography modifications. We aimed to identify a serological biomarker of sudden sensorineural hearing loss, and we also dosed and monitored the value of the serum neurofilament light (NfL). the best of our knowledge, this is the first report that associates SSHL and the serological increase in NfL as a potential biomarker of neuronal-disease-related damage.

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Update on Findings about Sudden Sensorineural Hearing Loss and Insight into Its Pathogenesis

Cited by 23 publications

References 111 publications

Importance of small vessel disease as a possible cause of sudden sensorineural hearing loss

Importance of small vessel disease as a possible cause of sudden sensorineural hearing loss

Development and validation for multifactor prediction model of sudden sensorineural hearing loss

Neurofilament Expression as a Biomarker of Post-COVID-19 Sudden Sensorineural Hearing Loss

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