Update on first unprovoked seizure in children and adults: A narrative review

Jiménez-Villegas, María José; Lozano-García, Lucas; Carrizosa-Moog, Jaime

doi:10.1016/j.seizure.2021.03.027

Cited by 21 publications

(15 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Перший епілептичний напад є тривожною подією, яка змінює життя кожного пацієнта та його родини й супроводжується проблемами не лише емоційного, але і соціального характеру. Дітей та їхні родини можуть турбувати ризики розвитку повторних нападів та нещасних випадків під час них, обмеження способу життя, публічний розголос, особливості здобуття певного фаху чи зміна виду діяльності у майбутньому [23]. Незважаючи на актуальність проблематики вивчення особливостей якості життя дітей після перенесеного ПНЕН, нами не було виявлено жодних наукових фактів цього спрямування.…”

Section: обговоренняunclassified

Quality of life indicators in children with non-traumatic and non-syncopal transient loss of consciousness and their families

Kovalchuk

Boyarchuk

2023

View full text Add to dashboard Cite

Background. There are extremely limited research on the quality of life in children with non-traumatic and non-syncopal transient loss of consciousness (TLOC), which does not sufficiently reflect the impact of epilepsy, first unprovoked epileptic seizure or psychogenic TLOC on the parental quality of life and family functioning. The purpose was to provide a comparative analysis of quality of life in children with non-traumatic and non-syncopal TLOC, as well as to study the impact of these diseases on the family quality of life. Materials and methods. Twenty-two patients with epilepsy, 18 with first unprovoked epileptic seizure, and 18 with psychogenic TLOC aged 8–17 years were examined. The control group consisted of 40 apparently healthy children. Quality of life in children and their parents was assessed using the PedsQL™ 4.0 Generic Core Scales (child report, adolescent report, parent report), and the PedsQL™ 2.0 Family Impact Module (parent report). Results. Epilepsy and psychogenic TLOC have a negative impact on the quality of life of children. Epilepsy was accompanied by deterioration of physical (57.1 ± 5.2; 77.3 ± 4.8 points) and psychosocial health (60.7 ± 5.7; 76.3 ± 2.7 points), while psychogenic TLOC were characterized by only low physical health (55.0 ± 5.5; 77.3 ± 4.8 points) according to patient self-reports (p < 0.01). The quality of life of children with epilepsy was influenced by age (r = –0.55; r = 0.007) and features of clinical manifestation of the epileptic seizure (r = –0.56; r = 0.007). The number of previous non-epileptic seizures had an impact on quality of life among patients with psychogenic TLOC (r = –0.60; r = 0.0008). The first unprovoked epileptic seizure was not accompanied by quality of life deterioration among children and parents. Only epilepsy was associated with a decrease in the quality of life of parents and family as a whole, mainly due to an increased anxiety (38.8 ± 4.5; 63.2 ± 4.0 points), a decrease in emotional functioning (47.5 ± 3.9; 66.9 ± 3.3 points), a lack of effective communication between family members (50.0 ± 4.8; 79.4 ± 2.9 points); p < 0.01. Conclusions. The combined evaluation of quality of life in children and their parents helps better understand the impact of disease course peculiarities and treatment on the child’s and his family’s quality of life in order to provide timely medical and psychological assistance.

show abstract

Section: обговоренняunclassified

Quality of life indicators in children with non-traumatic and non-syncopal transient loss of consciousness and their families

Kovalchuk

Boyarchuk

2023

View full text Add to dashboard Cite

show abstract

“…Clinical aspects range from updates on the first epileptic seizure presentation in children and adults, uncommon epileptic syndromes in childhood and new information on the complex relationship between neurocysticercosis, seizures and epilepsy [4][5][6]. The Brazilian group of Lutzky Saute et al demonstrate how the combination of high field magnetic imaging and with electric source imaging may improve the chances of achieving seizure freedom through the surgical treatment of MRI negative pharmacoresistant epilepsies [7].…”

Section: Celebrating the Lasse 15th Editionmentioning

confidence: 99%

Introduction to the special issue

Yacubian

Carrizosa

Cavalheiro

2021

Seizure

View full text Add to dashboard Cite

“…However, in developed countries, the incidence of epilepsy is more common at extreme ages both in children and the elderly 12 . Approximately, 5%–10% of old people have a seizure at the age of 80, increasing the chance of a second seizure by 40%–50% 13 …”

Section: Introductionmentioning

confidence: 99%

“…12 Approximately, 5%-10% of old people have a seizure at the age of 80, increasing the chance of a second seizure by 40%-50%. 13 The underlying mechanism of epileptic seizure is due to the epileptogenesis process which occurs by imbalance between inhibitory and excitatory neurotransmitters. 14 Reduction of inhibitory gammaaminobutyric acid (GABA) and increase of excitatory glutamate induce the development and progression of epileptogenesis.…”

Section: Introductionmentioning

confidence: 99%

New insights on the potential anti‐epileptic effect of metformin: Mechanistic pathway

Alnaaim,

Al‐kuraishy,

Al‐Gareeb

et al. 2023

J Cellular Molecular Medi

View full text Add to dashboard Cite

Epilepsy is a chronic neurological disease characterized by recurrent seizures. Epilepsy is observed as a well‐controlled disease by anti‐epileptic agents (AEAs) in about 69%. However, 30%–40% of epileptic patients fail to respond to conventional AEAs leading to an increase in the risk of brain structural injury and mortality. Therefore, adding some FDA‐approved drugs that have an anti‐seizure activity to the anti‐epileptic regimen is logical. The anti‐diabetic agent metformin has anti‐seizure activity. Nevertheless, the underlying mechanism of the anti‐seizure activity of metformin was not entirely clarified. Henceforward, the objective of this review was to exemplify the mechanistic role of metformin in epilepsy. Metformin has anti‐seizure activity by triggering adenosine monophosphate‐activated protein kinase (AMPK) signalling and inhibiting the mechanistic target of rapamycin (mTOR) pathways which are dysregulated in epilepsy. In addition, metformin improves the expression of brain‐derived neurotrophic factor (BDNF) which has a neuroprotective effect. Hence, metformin via induction of BDNF can reduce seizure progression and severity. Consequently, increasing neuronal progranulin by metformin may explain the anti‐seizure mechanism of metformin. Also, metformin reduces α‐synuclein and increases protein phosphatase 2A (PPA2) with modulation of neuroinflammation. In conclusion, metformin might be an adjuvant with AEAs in the management of refractory epilepsy. Preclinical and clinical studies are warranted in this regard.

show abstract

Update on first unprovoked seizure in children and adults: A narrative review

Cited by 21 publications

References 87 publications

Quality of life indicators in children with non-traumatic and non-syncopal transient loss of consciousness and their families

Quality of life indicators in children with non-traumatic and non-syncopal transient loss of consciousness and their families

Introduction to the special issue

New insights on the potential anti‐epileptic effect of metformin: Mechanistic pathway

Contact Info

Product

Resources

About