Update on Food Protein–Induced Enterocolitis Syndrome (FPIES)

Baker, Mary Grace; Berin, M. Cecilia; Sicherer, Scott H.

doi:10.1007/s11882-022-01037-y

Cited by 14 publications

(32 citation statements)

References 96 publications

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“…A food challenge is conducted when there is uncertainty regarding the culprit food. 30 Challenges should be performed in a medical setting under physician supervision due to the possibility of severe symptoms. 30 Many different protocols for FPIES exist, however, the optimal protocol has yet to be established.…”

Section: Diagnosismentioning

confidence: 99%

“… 30 Challenges should be performed in a medical setting under physician supervision due to the possibility of severe symptoms. 30 Many different protocols for FPIES exist, however, the optimal protocol has yet to be established. 31 The suggested dose of the challenge food being administered is 0.3 g food protein per kg of body weight (range 0.06–0.6 g).…”

Section: Diagnosismentioning

confidence: 99%

“… 26 Three equal doses of the cumulative serving size may be administered over a period of 30 min and patients should be observed 4–6 hr after ingestion. 30 Smaller starting doses and/or longer periods of observation may be considered more appropriate for patients with a history of severe symptoms. 30 If a very low starting dose is used and tolerated, a second full dose may be offered 2–3 hr after initial feeding, followed by a 4-hr observation period.…”

Section: Diagnosismentioning

confidence: 99%

“… 30 Smaller starting doses and/or longer periods of observation may be considered more appropriate for patients with a history of severe symptoms. 30 If a very low starting dose is used and tolerated, a second full dose may be offered 2–3 hr after initial feeding, followed by a 4-hr observation period. 30 Since most reactions occur 1 hr after ingestion, it is difficult to attribute the severity of the reaction to three equal doses within the suggested 30-min period.…”

Section: Diagnosismentioning

confidence: 99%

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Diagnostic and Management Strategies of Food Protein-Induced Enterocolitis Syndrome: Current Perspectives

Mulé,

Prattico,

Al Ali

et al. 2023

PHMT

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Food protein-induced enterocolitis syndrome (FPIES) is a form of non-IgE mediated food allergy that presents with delayed gastrointestinal symptoms after ingestion of the trigger food. The data regarding FPIES are sparse, despite being recognized as a distinct clinical entity. This narrative review presents the characteristics of this disorder in the pediatric population, as well-standard diagnostic and management protocols. FPIES can be classified into acute and chronic subtypes, and some cases may develop into an IgE-mediated allergy. Given that skin prick tests and specific IgE levels are negative in the majority of cases, diagnosis relies on clinical history and oral food challenges. Management involves elimination diets, assessment of tolerance through oral food challenges, and rehydration in the event of a reaction. Future research should focus on improving diagnostic methods, illustrating underlying pathogenesis and biomarkers, and assessing long-term natural history. Increased knowledge and awareness for FPIES are required.

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Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic and Management Strategies of Food Protein-Induced Enterocolitis Syndrome: Current Perspectives

Mulé,

Prattico,

Al Ali

et al. 2023

PHMT

View full text Add to dashboard Cite

show abstract

“…Despite this, FPIES is often under-recognized because of its non-specific symptoms and the absence of specific confirmatory tests [9]. Moreover, many primary care and emergency physicians are unaware of FPIES because of its relatively low incidence, and the specific International Classification of Diseases (ICD) code (2015) and diagnostic guidelines for this condition are still in their nascent form (2017) [10]. These considerations suggest that FPIES may be significantly underdiagnosed.…”

Section: Introductionmentioning

confidence: 99%

Discrepancy between Caregivers’ Reports and Physicians’ Evaluation of Causative Foods in Food Protein-Induced Enterocolitis Syndrome in Japan: The Japan Environment and Children’s Study

Kajita,

Kaneko,

Kuroki

et al. 2024

Int Arch Allergy Immunol

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Introduction: Food protein-induced enterocolitis syndrome (FPIES) is a form of non-IgE-mediated gastrointestinal food allergy. FPIES is considered a rare food allergy disorder and is often under-recognized. Therefore, clinicians should have a better understanding of its manifestations and maintain a high index of suspicion for a correct diagnosis. To this end, information about differences in the characteristics of caregiver-reported and physician-diagnosed FPIES is important. Methods: The present, national, multicentric, prospective birth cohort study, called the Japan Environment and Children’s Study (JECS), enrolled a general population of 104,062 fetal records. The characteristics of FPIES in 1.5-year-old children were categorized as cases reported by caregivers or as those diagnosed by a physician using questionnaire data. Results: The prevalence of caregiver-reported and physician-diagnosed FPIES cases was 0.69% and 0.06%, respectively. Among the former, the most common causative food was hen’s egg (HE), and the second most common causative food was cow’s milk (CM) (51.0% and 17.1% of patients responded to HE and CM, which accounted for 46% and 15% of all the causative foods, respectively). Conversely, among the physician-diagnosed cases, the most common causative food was CM followed by HE (57.7% and 36.5% of patients responded to CM and HE, which accounted for 46% and 29% of all the causative foods, respectively). CM accounted for a significantly higher proportion of causative foods in physician-diagnosed FPIES while HE accounted for a significantly higher proportion of caregiver-reported FPIES (p < 0.05). Conclusion: A discrepancy was found in reports of the most common causative food between caregiver-reported and physician-diagnosed cases of FPIES.

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Recent trends in food protein–induced enterocolitis syndrome (FPIES)

Baker

Sampson

2023

Journal of Allergy and Clinical Immunology

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Update on Food Protein–Induced Enterocolitis Syndrome (FPIES)

Cited by 14 publications

References 96 publications

Diagnostic and Management Strategies of Food Protein-Induced Enterocolitis Syndrome: Current Perspectives

Diagnostic and Management Strategies of Food Protein-Induced Enterocolitis Syndrome: Current Perspectives

Discrepancy between Caregivers’ Reports and Physicians’ Evaluation of Causative Foods in Food Protein-Induced Enterocolitis Syndrome in Japan: The Japan Environment and Children’s Study

Recent trends in food protein–induced enterocolitis syndrome (FPIES)

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