Update on International Medical Taxonomies of Biomarkers and Their Applications in Management of Thyroid Cancers

Trovato, Maria

doi:10.3390/diagnostics12030662

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…Further, these analyses are applied in dubious diagnoses of thyroid glandular cancerous lesions [45]. Mainly, these are part of thyroid innovative medicine that point trough biomarkers to early molecular diagnose, personalized treatment, prediction of cancerous risk and prognostic information [46].…”

Section: Molecular Biotechnologies (Mb) and Htmentioning

confidence: 99%

Medical Applications of Molecular Biotechnologies in the Context of the Hashimoto’s Thyroiditis

Trovato¹,

Valenti²

2023

Preprint

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Hashimoto’s thyroiditis (HT) is a gender autoimmune disease that is manifested by chronic inflammation of thyroid. Clinical trial studies (CTSs) use molecular biotechnologies (MB) to approach HT appearance. Aims of this study was to analyze the applications of MB in CTSs carried out in HT populations (HT-CTSs). Further, to evaluate the role of MB in the context of hygiene hypothesis (HH). From 75 HT-CTSs found at https://beta.clinicaltrials.gov/ web place, forty-five were considered for this investigation. Finally, six HT-CTSs were reported as molecular HT-CTSs (mHT-CTSs) because of these were planning to utilize MB. Two of mHT-CTSs were settled on French population to isolate DNA viral sequences. Blood, urine, and thyroid tissues biospecimens were analyzed to pick out parvo and polyoma viruses. Two mHT-CTSs carried out in China, were aimed to identify oral and fecal microbiotas by measuring PCR sequencing of 16S rRNA gene. Two mHT-CTSs were programmed in USA and Greece, respectively, for interception of DNA polymorphisms to associate with genetic susceptibility to HT. In conclusion, MB are mainly employed in HT-CTSs for infective pathogenesis and genetic fingerprinting of HT. Besides, MB don't prove the evidence of HH; however, they are useful for direct evidence of the presence of viruses.

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Section: Molecular Biotechnologies (Mb) and Htmentioning

confidence: 99%

Medical Applications of Molecular Biotechnologies in the Context of the Hashimoto’s Thyroiditis

Trovato¹,

Valenti²

2023

Preprint

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“…Nonetheless, the blamed genes are only part of a larger category of medical signs that are considered to be indicative of cancer physiopathology and are used in the management of thyroid cancers [27]. The U.S. Food and Drug Administration (FDA), National Institutes of Health (NIH), and the European Medicines Agency (EMA) have defined what should be included among biomarkers [28,29].…”

Section: Introductionmentioning

confidence: 99%

Papillary Thyroid Cancer Remodels the Genetic Information Processing Pathways

Iacobas,

Iacobas

2024

Genes

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The genetic causes of the differentiated, highly treatable, and mostly non-fatal papillary thyroid cancer (PTC) are not yet fully understood. The mostly accepted PTC etiology blames the altered sequence or/and expression level of certain biomarker genes. However, tumor heterogeneity and the patient’s unique set of favoring factors question the fit-for-all gene biomarkers. Publicly accessible gene expression profiles of the cancer nodule and the surrounding normal tissue from a surgically removed PTC tumor were re-analyzed to determine the cancer-induced alterations of the genomic fabrics responsible for major functional pathways. Tumor data were compared with those of standard papillary and anaplastic thyroid cancer cell lines. We found that PTC regulated numerous genes associated with DNA replication, repair, and transcription. Results further indicated that changes of the gene networking in functional pathways and the homeostatic control of transcript abundances also had major contributions to the PTC phenotype occurrence. The purpose to proliferate and invade the entire gland may explain the substantial transcriptomic differences we detected between the cells of the cancer nodule and those spread in homo-cellular cultures (where they need only to survive). In conclusion, the PTC etiology should include the complex molecular mechanisms involved in the remodeling of the genetic information processing pathways.

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“…Further, these analyses are applied in dubious diagnoses of thyroid glandular cancerous lesions [ 44 ]. Mainly, these are part of innovative thyroid medicine that aims through biomarkers to early molecular diagnosis, personalized treatment, the prediction of cancerous risk, and prognostic information [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Medical Applications of Molecular Biotechnologies in the Context of Hashimoto’s Thyroiditis

Trovato

Valenti

2023

Diagnostics

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Hashimoto’s thyroiditis (HT) is a gender autoimmune disease that is manifested by chronic inflammation of the thyroid. Clinical trial studies (CTSs) use molecular biotechnologies (MB) to approach HT appearance. The aims of this study were to analyze the applications of MB in CTSs carried out in HT populations (HT-CTSs). Further, to evaluate the role of MB in the context of the hygiene hypothesis (HH). From 75 HT-CTSs found at clinicaltrials.gov web place, forty-five were considered for this investigation. Finally, six HT-CTSs were reported as molecular HT-CTSs (mHT-CTSs) because these were planning to utilize MB. Two of mHT-CTSs were programmed on the French population to isolate DNA viral sequences. Blood, urine, and thyroid tissue biospecimens were analyzed to pick out the parvo and polyoma viruses. Two mHT-CTSs carried out in China aimed to identify oral and fecal microbiotas by measuring PCR sequencing of the 16S rRNA gene. Two mHT-CTSs were programmed in the USA and Greece, respectively, for interception of DNA polymorphisms to associate with genetic susceptibility to HT. In conclusion, MB are mainly employed in HT-CTSs for infective pathogenesis and genetic fingerprinting of HT. Furthermore, MB do not provide evidence of HH; however, they are useful for providing direct evidence of the presence of viruses.

show abstract

Update on International Medical Taxonomies of Biomarkers and Their Applications in Management of Thyroid Cancers

Cited by 3 publications

References 34 publications

Medical Applications of Molecular Biotechnologies in the Context of the Hashimoto’s Thyroiditis

Medical Applications of Molecular Biotechnologies in the Context of the Hashimoto’s Thyroiditis

Papillary Thyroid Cancer Remodels the Genetic Information Processing Pathways

Medical Applications of Molecular Biotechnologies in the Context of Hashimoto’s Thyroiditis

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