Update on Liposarcoma: A review for cytopathologists

Dodd, Leslie G.

doi:10.1002/dc.21794

Cited by 62 publications

(93 citation statements)

References 107 publications

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“…Liposarcomas are malignant adipocytic solid tumors representing a heterogeneous group of lesions classified into 4 major types by the World Health Organization DOI: 10.1159/000486333 (WHO): atypical lipoma/well-differentiated liposarcoma, and myxoid, pleomorphic, and dedifferentiated liposarcoma [15]. Because of the strong correlation between tumor prognosis and aggressiveness in localized liposarcomas, tumor grading constitutes an extremely important approach for decision-making in treatment.…”

Section: Discussionmentioning

confidence: 99%

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Liposarcoma of the Thyroid: A Case Report with a Review of the Literature

Guarda

Pickhard

Boxberg³

et al. 2018

Eur Thyroid J

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Background: Liposarcomas of the thyroid gland are extremely rare tumors, and, to our knowledge, only 12 cases have been reported in the English literature. An accurate diagnosis is challenging due to the nonspecific clinical presentation of this cancer, frequently defined just by a swelling of the neck. Patient Findings: We present an 82-year-old woman with liposarcoma of the thyroid, complaining of a fast-growing neck mass. MRI and neck ultrasound showed a large lipomatous mass, which corresponded to a cold nodule in the thyroid scan. After performing a total thyroidectomy, the diagnosis of a well-differentiated liposarcoma of the thyroid gland was made, showing an MDM2 amplification in fluorescence in situ hybridization. Since neither a metastasis nor a residual tumor was found, no further adjuvant therapy was needed. Results: We searched the literature for previous case reports and identified only 12 cases worldwide to form our database. A demographic as well as clinical and histopathological analysis was made. In most cases, the liposarcoma occurred in patients >60 years of age. All histological subtypes, such as well-differentiated and myxoid liposarcomas, and pleomorphic and dedifferentiated liposarcomas, were found in the literature. In only 38.46% of the cases, an infiltration of the adjacent organs was observed. Surgery was the most common treatment chosen. Conclusions: Our review provides clinical and histopathological features of a primary liposarcoma of the thyroid to enable the identification of this rare tumor entity and assist in the decision-making process regarding therapeutic options and tumor follow-up.

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Section: Discussionmentioning

confidence: 99%

“…However, recent studies underline the higher FISH sensitivity for MDM2 amplification as a diagnostic solution in difficult lipomatous tumors [24]. Besides that, other cytogenetic studies would help establishing a definitive diagnosis, like the identification of the fusion gene FUS-CHOP in myxoid liposarcomas [15].…”

Section: Discussionmentioning

confidence: 99%

Liposarcoma of the Thyroid: A Case Report with a Review of the Literature

Guarda

Pickhard

Boxberg³

et al. 2018

Eur Thyroid J

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“…Furthermore, these subtypes are also associated with a slightly different patient prognosis. The 5-year overall survival of well-differentiated LS, dedifferentiated LS, myxoid LS were 93.3%, 54.4% and 75.7%, respectively [9,10]. It is noteworthy that some distinctive molecular signatures are shown in the common subtypes.…”

Section: Discussionmentioning

confidence: 94%

“…It is noteworthy that some distinctive molecular signatures are shown in the common subtypes. About 90% of the well/ dedifferentiated LS demonstrate significant overexpression of oncogene MDM2 [10]. Myxoid/round cell LS is characterized by the chromosome rearrangement, t(12; 16)(q13;p11), which results in the FUS-DDIT3 gene fusion [9,10].…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Cerebellar Degeneration Associated with Pelvic Liposarcoma: A Rare Case Report

Zhou¹,

Wei²,

Wu³

et al. 2017

Urol Int

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Paraneoplastic cerebellar degeneration (PCD) is one of the most common paraneoplastic neurological syndromes characterized by the rapid development of severe cerebellar ataxia. In this report, a 23-year-old female with noticeable dizziness and gait instability was described. The enhanced CT scanning suggested the presence of a pelvic tumor. Then, PCD was established. Postoperative pathological result defined it as a liposarcoma (LS) with dedifferentiation. Interestingly, clinical symptoms disappeared after the surgical removal of the pelvic tumor. To our knowledge, this was the first case report with PCD due to LS.

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“…6 The World Health Organization divides LPS into 5 histologic subtypes, which can be grouped into 3 broad conceptual categories as follows: atypical lipomatous tumor (ALT)/well-differentiated LPS and dedifferentiated LPS; myxoid LPS; and pleomorphic LPS. 4,7 The first category, including both ALT and dedifferentiated LPS, is the most common LPS subgroup comprising 50% of all cases. 8 Atypical lipomatous tumors are locally aggressive but lack metastatic potential.…”

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confidence: 99%