Update on management of hypertriglyceridaemia-induced acute pancreatitis

Sahu, Kamal Kant; Mishra, Ajay Kumar; Lal, Amos; Silverman, Eric S.

doi:10.1136/bcr-2019-231703

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…As per the results, HVHF lowered triglyceride levels more quickly than LMWH plus insulin therapy, but no difference was noted in terms of clinical outcomes, local pancreatic complications, need of surgery and cost. 7 Following the initial management, appropriate measures are necessary to decrease serum triglyceride levels to decrease the risk of relapse.…”

Section: Discussionmentioning

confidence: 99%

An interesting case of acute pancreatits

et al. 2022

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Hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis but it is relatively rare and requires a high level of clinic suspicion. We report a 30 years old male with no co-morbidities who is a non-alcoholic, non-smoker presented with epigastric pain associated with vomiting for two days. His vitals were stable and systemic examination was unremarkable. Serum lipase levels were elevated [7365 U/l (<40 U/l)]. Computed Tomography of the abdomen suggested acute pancreatitis with extensive peri-pancreatic inflammatory changes with no evidence of pancreatic necrosis. Serum triglycerides were found to be elevated (3450 mg/dl). A diagnosis of HTG induced acute pancreatitis was made. During evaluation he was found to be diabetic. He was treated with intravenous fluids, IV insulin infusion, and other supportive measures. He was started on statins, fenofibrate and omega 3 fatty acids. His condition improved and triglyceride levels after two days were in a declining trend and he was discharged on the same. He was currently under follow up and his serum amylase, serum lipase, serum triglycerides were normal. This case report provides insight into rare cause of acute pancreatitis-HTG which if diagnosed at the earliest can be treated promptly.

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Section: Discussionmentioning

confidence: 99%

An interesting case of acute pancreatits

et al. 2022

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“…Free fatty acids released during the lipolysis of triglycerides are generally believed to be bound to serum albumin and in this form are not toxic. If large quantities of fatty acids were released from triglycerides, they would be toxic to the tissues and could result in acinar cell and/or capillary injury [1,4].…”

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confidence: 99%

“…Whether the actual episode of pancreatitis is caused directly by the alcohol or by the lipid abnormality is unclear [1,4,5].…”

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confidence: 99%