Update on nonallergic rhinitis

Settipane, Russell A.; Lieberman, Philip

doi:10.1016/s1081-1206(10)62896-7

Cited by 196 publications

(164 citation statements)

References 67 publications

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“…Also it was assumed that approximately 22 million people suffer from a combination of nonallergic rhinitis and allergic diseases (mixed rhinitis). Both forms, mixed and nonallergic rhinitis occur more frequently in adults, may be more common in female patients and are more likely to be perennial than seasonal (32).…”

Section: Introductionmentioning

confidence: 99%

Toxic Rhinitis-Induced Changes of Human Nasal Mucosa Innervation

et al. 2003

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Irritative toxic rhinitis is a nasal disorder induced by chemical compounds like ozone, formaldehyde, nickel, chrome, solvents and tobacco smoke. These noxious stimuli may have effects on the nasal innervation leading to a cascade of neuro-immune interactions and an augmentation of the symptoms. Here we examined changes in the neuropeptide content of mucosal parasympathetic, sympathetic and sensory nerves of patients with toxic rhinitis caused by chronic cigarette smoke exposure. Semiquantitative immunohistochemistry using antibodies against calcitonin gene-related peptide (CGRP), substance P (SP), neuropeptide tyrosine (NPY), and vasoactive intestinal peptide (VIP) was carried out on cryostat sections of human nasal mucosa obtained from normal subjects and patients with toxic rhinitis and revealed significant differences between both groups. Toxic rhinitis patients had significantly elevated expression scores for VIP (2.83 ± 0.31 vs 1.27 ± 0.47 control group) and NPY (3.17 ± 0.31 vs 0.91 ± 0.37 control group) revealing an increase of mediators in distinct subpopulations of airway nerves. In summary, the present studies indicate a differential participation of subclasses of mucosal nerves in the pathophysiology of toxic rhinitis. Airway innervation may have a major role in the pathophysiology of toxic rhinitis associated with chronic cigarette smoke exposure.

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Section: Introductionmentioning

confidence: 99%

Toxic Rhinitis-Induced Changes of Human Nasal Mucosa Innervation

et al. 2003

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“…Rinit tanısı, günde bir saatten fazla süren burun tıkanıklığı, burun kaşıntısı, hapşırma ve koku almada azalmayı kapsayan nazal semptomlardan ikisinin olması ile konulur [14,15]. Epidemiyolojik çalışmalarda, kronik rinitli olguların yaklaşık %50'sinin alerjik kökenli olduğu saptanmıştır [16,17].Epidemiyolojik çalışmala-rı güçleştiren bir başka durum da aynı olguda alerjik olmayan rinit ile alerjik rinitin birlikteliğidir. Yapılan bir çalışmada saf alerjik rinit %43, saf alerjik olmayan rinit %23 ve ikisi birlikte %34 oranında bulunmuştur.…”

Section: Discussionunclassified

The Evaluation of Thyroid Function Disorders in Patients with Allergic Rhinitis

Akkoca¹

2015

Ann Clin Anal Med

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Anahtar KelimelerAlerjik Rinit; Deri Prick Test; Hipotiroidi Abstract Aim: In this study, we aimed to determine the ratio of thyroid hormone disorders in subjects with allergic rhinitis and investigate the association between these two diseases. Material and Method: 62 patients who presented with symptoms of allergic rhinitis and have positive skin prick test and 62 patients as a control group were included in the study to examine thyroid hormone disorders. Results: Mean age of patients with allergic rhinitis were 43.20 ± 18.55. 54.4% of the patients were females and 45.6% of the patients were males. Thyroid hormone results were; 2.33 ± 1.69 for FT3, 2.40 ± 1.96 for FT4, 4.49 ± 3.61 for TSH. Subclinical hyperthyroidism, euthyroidism,subclinical hypothyroidism and clinical hypothyroidism were detected in 4.8%, 61.4 %,29% and 4.8% of patients,respectively. Mean age of patients with allergic rhinitis were 40.03 ± 17.7. 55% of the patients were females and 45% of the patients were males. Thyroid hormone results were; 2 , 21 ± 1.45 for FT3, 2 , 40 ± 1.81 for FT4, 4. 22 ± 4.37 for TSH. Subclinical hyperthyroidism, euthyroidism,subclinical hypothyroidism and clinical hypothyroidism were detected in 9.5%, 68.3 %,12.7% and 9.5% of patients,respectively. There was no difference between patient and control groups in terms of hypothyroidism, euthyroidism and hyperthyroidism (p = 0.35). There was no difference between genders in terms of hypothyroidism, euthyroidism and hyperthyroidism(p = 0.40). Discussion: No deterioration in thyroid functions were found in patients with symptoms of allergicrhinitis.

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“…Some studies have shown that intranasal corticosteroids are particularly effective in the treatment ofNAR when nasal eosinophilia is present (29). The options in the treatment of NAR patients who have few or no eosinophilia in nasal smears include either non-specific, broad-based therapy aimed at multiple symptoms or, alternatively, therapy tailored to treat specific symptoms (30)(31). The effectiveness ofintranasal corticosteroid therapy in NAR without eosinophils has not been clearly demonstrated (12,29,(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

“…The options in the treatment of NAR patients who have few or no eosinophilia in nasal smears include either non-specific, broad-based therapy aimed at multiple symptoms or, alternatively, therapy tailored to treat specific symptoms (30)(31). The effectiveness ofintranasal corticosteroid therapy in NAR without eosinophils has not been clearly demonstrated (12,29,(31)(32)(33). Nonetheless, there is a clinical impression that intranasal corticosteroids are not as effective in NAR without eosinophils, as in NARES (29,34).…”

Section: Discussionmentioning

confidence: 99%

Clinical Importance of Eosinophil Count in Nasal Fluid in Patients with Allergic and Non-Allergic Rhinitis

Lorenzo

Mansueto

Pacor

et al. 2009

Int J Immunopathol Pharmacol

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Eosinophil count in nasal fluid (ECNF) was used to differentiate nasal pathologies. Receiver Operating Characteristic (ROC) curve analysis and the area under the curve (AVC) were performed to evaluate the ECNF's accuracy in distinguishing allergic rhinitis (AR) from non-allergic rhinitis (NAR). We also evaluated the accuracy of ECNF in recognizing patients with mild and severe symptoms of rhinitis and patients with ineffective and effective clinical responses to antihistamines. 1,170 consecutive adult patients with a clinical history of rhinitis were studied. ECNF's median in AR was 6.0 and 2.0 in NAR and the best cut-off value was> 3.0, AVC = 0.75. ECNF's median in AR with mild nasal symptoms was 3.0 and 7.0 with severe symptoms, and the best cut-off value was 4.0, AV C =0.90. ECNF's median in NAR with mild nasal symptoms was 2.0 and 8.5 with severe symptoms, and the best cut-off value was> The most common diagnostic tests for allergic rhinitis are the Skin Prick Test (SPT) and the determination of serum allergen-specific IgE. A less common diagnostic tool is nasal cytology. Nasal cytology is generally employed by subspecialists or in research, but does not play a role in the routine evaluation of rhinitis (1). The techniques for obtaining cells for cytology in lavage, or brushings, have not been standardized as the criteria for evaluating cell counts (2). Nasal lavage is the reference method among adult patients (3). Brushing was compared to lavage among adults by Juliusson et al. They found a strong correlation between the two methods regarding the percentage of eosinophils

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Update on nonallergic rhinitis

Cited by 196 publications

References 67 publications

Toxic Rhinitis-Induced Changes of Human Nasal Mucosa Innervation

Toxic Rhinitis-Induced Changes of Human Nasal Mucosa Innervation

The Evaluation of Thyroid Function Disorders in Patients with Allergic Rhinitis

Clinical Importance of Eosinophil Count in Nasal Fluid in Patients with Allergic and Non-Allergic Rhinitis

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