Update on postprandial hyperglycemia: The pathophysiology, prevalence, consequences and implications of treating diabetes

Corrales, Pedro José Pinés; Castañeda, Virginia Bellido; Ampudia‐Blasco, Francisco Javier

doi:10.1016/j.rceng.2018.12.002

Cited by 7 publications

(6 citation statements)

References 89 publications

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“…In line with a number of epidemiological studies [ 34 ], postprandial hyperglycaemia was considered to be a CV risk factor by consensus in this study and, consequently, its monitoring and an individualized treatment strategy would be advisable: DPP-4 inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have been shown to be effective in the reduction of postprandial hyperglycaemia [ 34 – 36 ].…”

Section: Discussionmentioning

confidence: 72%

Are There Different Viewpoints About the Management of Type 2 Diabetes Mellitus and Comorbidities? A Multidisciplinary Spanish Qualitative Research

2021

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Introduction:The aim of this study was to explore the vision of a large multidisciplinary group of physicians treating type 2 diabetes mellitus (T2DM) in Spain, with a special focus on controversial management aspects. The perceptions of primary care (PC) physicians and hospital care (HC) specialists were compared. Methods: This was a mixed survey that included Delphi-like statements and opinion, attitude and behaviour (OAB) questions. The Delphi-like statements were assessed on the basis of the degree of agreement among respondents, and a descriptive analysis was performed on the answers to the OAB questions. Results: A total of 296 participants responded to the first wave of the survey, of whom 293 responded to the second wave (211 from PC and 80 from HC, with two respondents for whom there were no data on specialty). A high degree of consensus (CNS C 0.8) was obtained in all the statements. A proactive approach to detect prediabetes or T2DM in asymptomatic people was highly supported (80.4% of agreement). Introducing early treatment intensification was considered to favour the durability of glycaemic control and to delay the progression of the disease (80.4%). There was agreement on the statement that glycaemic variability constitutes a risk factor for chronic complications, although differences in the perceptions of HC physicians and PC specialists were identified (86.3 vs. 80.1%, respectively). More HC physicans than PC specialists considered comorbidities to affect the ability to self-care (95 vs. 82.9%, respectively). Conclusions: The survey revealed that there was a high, albeit not universal, degree of agreement amongst PC physicians and HC specialists in relation to prevention, screening and diagnosis of T2DM; early treatment intensification; dysglycaemias; and the management of patients with comorbidities. The statement on the management of patients with comorbidities elicited the highest difference between PC physicans and HC specialists. The results of this survey indicate that there is room for

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Section: Discussionmentioning

confidence: 72%

Are There Different Viewpoints About the Management of Type 2 Diabetes Mellitus and Comorbidities? A Multidisciplinary Spanish Qualitative Research

2021

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“…Inhibiting alpha-glucosidases thus retards glucose liberation from carbohydrates, delays glucose absorption and reduces postprandial hyperglycemia [ 4 ]. Postprandial hyperglycemia has been reported to be associated with mortality and cardiovascular disease and its treatment using acarbose, an alpha-glucosidase inhibitor, has been associated with a reduction in cardiovascular events [ 3 ]. In the present study, the combination of PN + PR + ZO or Trikatuk prepared from the extract mixture exhibited alpha-glucosidase inhibitory activity comparable to that of acarbose.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, postprandial hyperglycemia has been reported to be associated with mortality and cardiovascular disease. The treatment of postprandial hyperglycemia using acarbose, an alpha-glucosidase inhibitor, has also been associated with a reduction in cardiovascular events [ 3 ]. Alpha-glucosidases are enzymes located in the brush border of the enterocytes and are responsible for hydrolyzing carbohydrates into glucose.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of Trikatuk, a traditional Thai formulation, on antioxidant and alpha-glucosidase inhibitory activities

Nutmakul

Chewchinda

2023

Heliyon

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“…However, persistent hyperglycaemia leads to excessive body weight gain, diabetes and consequent cardiovascular risks. In those with diabetes, uncontrolled glycaemia expedites systemic complications 2 (Figure 1).…”

Section: Postprandial Glycaemia As a Metabolic Targetmentioning

confidence: 99%

Glycaemic Index – helping Malaysian consumers optimise food choice

Shyam

2020

IeJSME

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Malaysia's high and rising obesity and diabetes prevalence draw national concern. While improved screening in part explains this scenario, intergenerational transmission and environmental amplification are important contributors. Thus, it is with worry we reckon that Malaysia is among the few nations that showed an unhealthy trend of increasing body weight but plateauing height gains among children, over the past four decades.1 Therefore, prevention and treatment of excessive weight gain and diabetes are of immediate and prime importance. Fortunately, obesity and diabetes have modifiable risks. In this editorial, the rationale for using the Glycaemic Index (GI) to optimise food choice for disease risk reduction and management is discussed.

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Update on postprandial hyperglycemia: The pathophysiology, prevalence, consequences and implications of treating diabetes

Cited by 7 publications

References 89 publications

Are There Different Viewpoints About the Management of Type 2 Diabetes Mellitus and Comorbidities? A Multidisciplinary Spanish Qualitative Research

Are There Different Viewpoints About the Management of Type 2 Diabetes Mellitus and Comorbidities? A Multidisciplinary Spanish Qualitative Research

Synergistic effect of Trikatuk, a traditional Thai formulation, on antioxidant and alpha-glucosidase inhibitory activities

Glycaemic Index – helping Malaysian consumers optimise food choice

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