Update on retinopathy of prematurity: treatment options and outcomes

Salvin, Jonathan; Lehman, Sharon S.; Jin, Jing; Hendricks, Dorothy

doi:10.1097/icu.0b013e32833cd40b

Cited by 36 publications

(27 citation statements)

References 31 publications

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“…The same factors playing important roles in the stages of normal development of the retinal vasculature are likely involved with the pathological neovascularization (Biglan et al, 1986;Salvin et al, 2010;Hard and Hellstrom, 2011). Several angiogenic inhibitors have been identified which effectively inhibit pathological neovascularization, but today the effects of such antiangiogenic factors on normal and pathologic retinal vascular development are not clear.…”

Section: Introductionmentioning

confidence: 99%

“…The abnormal vascularity can cause retinal-vitreal hemorrhage, retinal traction, optical disc traction, and macular or retinal detachment. Early and timely treatment is of benefit in most cases (Salvin et al, 2010). ROP is commonly treated with argon laser photocoagulation, but in some cases, this treatment may not yield any benefit.…”

Section: Introductionmentioning

confidence: 99%

“…ROP is commonly treated with argon laser photocoagulation, but in some cases, this treatment may not yield any benefit. In these cases, antivascular endothelial growth factor (anti-VEGF) therapy may be beneficial (Salvin et al, 2010;Mintz-Hittner and Best, 2009). …”

Section: Introductionmentioning

confidence: 99%

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Assessment of serum levels of angiogenic factors in dizygotic twin infants with and without retinopathy of prematurity

Demir¹,

Ortak²,

Aygün³

et al. 2013

jecm

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Article HistoryReceived 23 / 11 / 2012 Accepted 13 / 01 / 2013The aim of the study was to evaluate the plasma concentrations of vascular endothelial growth factor (VEGF-A), its soluble receptors VEGFR-1 and VEGFR-2, insulin like growth factor (IGF-1) and soluble Tie-2 in twin infants with and without retinopathy of prematurity (ROP). Eleven pairs of twin infants (total 22 infants) were included in the study: There were 11 infants with advanced stage ROP in the study group and 11 infants with no ROP in the control group. Before time-point measurements, the peripheral venous blood samples were first centrifuged, and the plasma was then stored at -70°C. The plasma concentrations of the angiogenic factors were measured by using highsensitivity enzyme-linked immunosorbent assay (ELISA) kits. The average gestational age of the infants at the time of birth and the time at which the serum samples were collected were 30.5±2.3 and 37.5±2.5 weeks, respectively. The average serum levels of all the angiogenic factors were higher in infants with ROP, but the differences were not statistically significant (p>0.05). In this study, serum samples of twins with and without ROP were evaluated simultaneously. The time of serum sampling in the study group corresponded to the period of phase 2 ROP. Therefore, there appeared to be no difference between the ROP group and the control group.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of serum levels of angiogenic factors in dizygotic twin infants with and without retinopathy of prematurity

Demir¹,

Ortak²,

Aygün³

et al. 2013

jecm

View full text Add to dashboard Cite

show abstract

“…There was a history of premature delivery at 30 weeks with oxygen therapy. USG of both orbits was performed with high resolution linear probe (7)(8)(9)(10)(11)(12). Axial length of both eye balls was 10 mm.…”

Section: Case Reportmentioning

confidence: 99%

Role of ultrasound in retinopathy of prematurity: a case report

Khaladkar

Kotkar

Kulkarni

et al. 2018

Sri Lanka J. Radiol.

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“…Cataracts occur frequently in this high risk population [2] [3] and cataract surgery may be complicated due to history of previous vitreoretinal surgery or ocular changes due to the ROP. Postoperative management may present additional challenges due to refractive changes over time, visual axis opacification (VAO), and anatomic retinal changes [4] [5] [6] [7].…”

mentioning

confidence: 99%

Outcome of Cataract Surgery in Patients Treated for Retinopathy of Prematurity

Nguyen¹,

Yen²

2017

OJOph

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Background/Aims: Pediatric patients with treated retinopathy of prematurity (ROP) may develop visually significant cataracts. We report the outcome of cataract surgery in patients who had ROP treatment. Method: Retrospective chart review of 19 eyes from 16 patients who had ROP treatment and subsequent cataract surgery between August, 2002 and March, 2015. Results: Eighteen of 19 eyes received laser treatment for ROP; 1 eye received intravitreal bevacizumab. 5 eyes received lens-sparing pars plana vitrectomy (LSPPV) in addition to laser. Average follow up was 10.1 ± 5.5 years. Average visual acuity improved from 20/324 prior to and 20/110 after cataract surgery (p = 0.06). 13/19 (68%) of the eyes received laser only and developed cataracts an average of 6.2 ± 5.6 years after laser treatment. 5/19 (26%) eyes developed cataracts an average of 6.4 ± 4.2 years after LSPPV and laser. In one eye, a cataract developed after a bevacizumab injection 2.9 years after the injection. Visual axis opacification (VAO) developed in 2/5 (40%) eyes after Ce/PCIOL/PPC-Antvx, 8/10 eyes (80%) after CE/IOL, and in 0/4 eyes after CE/PPC-AntVx. Ocular comorbidities included strabismus, nystagmus, amblyopia, optic atrophy, corneal band keratopathy, and phthisis bulbi. Conclusion: Cataract surgery in patients who have a history of ROP can be complicated by anatomical changes from prematurity and prior vitreoretinal surgeries. Vision improvement is limited by other ocular comorbidities.

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Update on retinopathy of prematurity: treatment options and outcomes

Abstract: This review offers an update on the screening and treatment guidelines, new treatment options, and short-term and long-term complications in ROP.

Cited by 36 publications

References 31 publications

Assessment of serum levels of angiogenic factors in dizygotic twin infants with and without retinopathy of prematurity

Assessment of serum levels of angiogenic factors in dizygotic twin infants with and without retinopathy of prematurity

Role of ultrasound in retinopathy of prematurity: a case report

Outcome of Cataract Surgery in Patients Treated for Retinopathy of Prematurity

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