Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

Thompson, Lester D.�R.; Fanburg‐Smith, Julie C.

doi:10.1007/s12105-016-0697-6

Cited by 34 publications

(36 citation statements)

References 87 publications

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“…Nasal obstruction and epistaxis are the most common presenting features of these tumours. They are usually unilateral and small in size with a mean size of 4.7cm [1,2,5] which was similar to the findings in the present series. The present series also observed the presence of a deviated nasal septum owing to the growth of tumour within the confined space of the nasal cavity.…”

Section: Resultssupporting

confidence: 91%

“…[5] reported the largest series of six cases diagnosed over a period of 10 years and provided a comprehensive review of the cases published medical literature. The age group of presentation of Sino nasal SFT is the fourth and fifth decade of life with almost equal gender predilection [1,5] . The present series also concurs with the age group however a male preponderance is seen which is similar to the findings of Thompson LDR et al [5] .…”

Section: Resultsmentioning

confidence: 99%

“…Solitary fibrous tumour (SFT) is a mesenchymal tumour, first described in 1942 by Stout and Murrey [1] . Word Health Organisation in 2017 revised the classification of Sino nasal tumours and Sino nasal hemangiopericytoma as SFT.…”

Section: Introductionmentioning

confidence: 99%

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Sinonasal solitary fibrous tumour: A borderline entity with diagnostic challenges

Singh¹,

Mathew²,

Kudva³

et al. 2019

Int. J. Clin. Diagn. Pathol.

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Introduction: Sino nasal Solitary Fibrous Tumour (SFT) has been categorised as borderline/low-grade malignant tumours in the recent WHO classification of Head and Neck Tumours (2017). SFT have been reported in pleura and diverse extra pleural sites of which Sino nasal region accounts for <0.1%. Owing to its overlapping histopathological features with various oval/spindle cell lesions in the region, Sino nasal SFT often poses as a diagnostic dilemma. Materials and methods: Eight cases diagnosed as Sino nasal SFT, over a period of twelve years (January 2006-December 2017) were retrieved from the archives of Department of Pathology, Kasturba Medical College, Manipal and reviewed for clinical-morphological features. Results: Sino nasal SFT was largely seen in males (M: F-3:1) with a median age of 54.5 years (33-74years). The predominant symptoms were nasal blockage, deviated nasal septum and occasional episodes of epistaxis. Grossly, the tumours appeared polypoidal to irregular masses, filling up the nasal cavity and extending to the nasopharynx and skull base. Microscopically, the tumours were composed of vague lobules of haphazardly arranged bland oval/spindle cells separated by collagen bundles and interspersed irregular vessels and were diffuse and strongly positive for CD34 on immunohistochemistry. Conclusion: SFT is characterized by cytological bland spindle cells with scant cytoplasm separated by thick collagen bundles, arranged in variable architectural patterns. These features show considerable overlap with angiofibroma, leiomyoma, schwannoma and fibrous histiocytomas especially in the presence of high cellularity and hypo/ hyper cellular architecture. The diagnostic clues favouring SFT include bands of collagen and positivity for CD34 and Bcl2. SFT are tumours with borderline/ lowgrade histology and can be managed by endoscopic resection. The poor prognostic indicators include old age, presence of tumour necrosis, >4 mitosis/10 HPF, and local recurrence is seen in 10-15% cases.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

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Sinonasal solitary fibrous tumour: A borderline entity with diagnostic challenges

Singh¹,

Mathew²,

Kudva³

et al. 2019

Int. J. Clin. Diagn. Pathol.

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“…Hence, sinonasal HPCs (glomangiopericytomas) have nuclear expression of beta-catenin and no nuclear expression of STAT6, because almost all sinonasal HPCs harbor CTNNB1 mutations and no NAB2-STAT6 fusion gene [33][34][35]. Agaimy et al suggested that sinonasal HPCs were different from sinonasal SFTs [10].…”

Section: Primary Sitementioning

confidence: 99%

Clinicopathological differences between variants of the NAB2–STAT6 fusion gene in solitary fibrous tumors of the meninges and extra-central nervous system

2016

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Investigations on the NAB2-STAT6 fusion gene in solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) have increased since its discovery in 2013. Although several SFTs reported without NAB2-STAT6 fusion gene analysis, we reviewed 546 SFTs/HPCs with NAB2-STAT6 fusion gene analysis in this study and investigated differences between the gene variants. In total, 452 cases tested positive for the NAB2-STAT6 fusion gene, with more than 40 variants being detected. The most frequent of these were NAB2 exon 6-STAT6 exon 16/17/18 and NAB2 exon 4-STAT6 exon 2/3, with the former occurring most frequently in SFTs in meninges, soft tissues, and head and neck; the latter predominated in SFTs in the pleura and lung. There was no difference between the histology of SFTs and fusion gene variants. A follow-up analysis of SFTs showed that 51 of 202 cases had a recurrence, with 18 of 53 meningeal SFTs having a local recurrence and/or metastasis within 0-19 years. In meninges and soft tissue, SFTs with the NAB2 exon 6-STAT6 exon 16/17/18 tended to recur more frequently than SFTs with the NAB2 exon 4-STAT6 exon 2/3. Clinicopathological data, including yearly follow-ups, are required for meningeal SFTs/HPCs to define the correlation of variants of NAB2-STAT6 fusion gene.

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“…The importance of long-term follow-up is illustrated in our study by 2 cases of angiofibroma with documented tumor growth 35 months after the initial operative therapy. Hemangioma and GPCs are other rare neoplasms of the sinonasal tract [28] . For those tumors surgical and, if possible, endoscopic tumor excision is recommended [29] .…”

Section: Clinical Datamentioning

confidence: 99%

A Clinical and Radiological Approach to the Management of Benign Mesenchymal Sinonasal Tumors

Anschuetz

Buchwalder²,

Dettmer³

et al. 2017

ORL

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Keywords Sinonasal mass · Benign mesenchymal sinonasal neoplasms · Osteoma · Fibrous dysplasia · Computed tomography · Magnetic resonance imaging AbstractPurpose: Benign mesenchymal sinonasal neoplasms (BMSN) are rare and histologically heterogeneous. Differential diagnosis, appropriate management, and outcome are still a matter of debate. The aim of this study is to provide evidence for further refinement of assessment and treatment in the future. Procedures: We retrospectively reviewed data on 93 patients with neuroradiologically verified BMSN treated at our university reference center during the past 22 years. Results: The most frequent BMSN recorded in our cohort was osteoma of the frontal sinus. Only one-third of the patients affected were symptomatic at initial presentation. The 2 other common fibro-osseous tumor entities, fibrous dysplasia and ossifying fibroma, were confirmed in 12 and 6 patients, respectively. Patients with soft tissue tumor entities such as hemangioma, glomangiopericytoma, angiofibroma, and hamartoma were all symptomatic and underwent surgical resection. Conclusion: Understanding and recognizing the spectrum of appearances of benign mesenchymal sinonasal tumors will improve patient assessment and clinical management. The pathognomonic neuroradiological signs of a particular tumor entity should be actively sought as the neuroradiological features may be the diagnostic clues. Computed tomography and magnetic resonance imaging play complementary roles in identifying the morphological details and locoregional staging of benign mesenchymal sinonasal tumors.

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Update on Select Benign Mesenchymal and Meningothelial Sinonasal Tract Lesions

Cited by 34 publications

References 87 publications

Sinonasal solitary fibrous tumour: A borderline entity with diagnostic challenges

Sinonasal solitary fibrous tumour: A borderline entity with diagnostic challenges

Clinicopathological differences between variants of the NAB2–STAT6 fusion gene in solitary fibrous tumors of the meninges and extra-central nervous system

A Clinical and Radiological Approach to the Management of Benign Mesenchymal Sinonasal Tumors

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