Update on the application of amniotic membrane in immune-related ocular surface diseases

Chen, Ziyan; Lao, Hubert Yuenhei; Liang, Lingyi

doi:10.4103/tjo.tjo_16_21

Cited by 15 publications

(5 citation statements)

References 77 publications

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“…However, in many SJS cases, the systemic condition is devastating, such as respiratory failure, which makes patients not suitable for invasive surgical intervention. ProKera ® offers the advantage of an easily performed technique, making it readily available for non-ophthalmic physicians, particularly in the bedside settings of intensive care units or emergency rooms [22]. We demonstrated one case of acute SJS (case 6) with complete remission and 2 cases of chronic SJS (cases 4 and 5) with chronic inflammation sequela.…”

Section: Discussionmentioning

confidence: 91%

Self-Retained, Sutureless Amniotic Membrane Transplantation for the Management of Ocular Surface Diseases

Chiu,

Tsai

2023

JCM

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Amniotic membrane (AM) has anti-inflammation, anti-fibrotic, and regenerative effects. Sutureless cryopreserved AM transplantation, ProKera® (Bio-Tissue, Inc., Miami, FL, USA), is easily applied by ophthalmologists in the treatment of ocular surface diseases. This retrospective study included patients with ocular surface diseases who received ProKera® between January 2022 and May 2023. Six patients (9 eyes) with a mean age of 56.8 ± 20.8 years old (range 25–74) and a mean follow-up period of 7.8 ± 4.1 months (range 1–12) were included, including 2 of recurrent conjunctival tumors with limbal and corneal involvement (cases 1–2), 1 of pterygium with marked astigmatism (case 3) and 3 of Stevens–Johnson syndrome (SJS, cases 4–6). ProKera® was inserted after the lesion excision and deep keratectomy in cases 1–3, and no recurrence or corneal complication was noted. Cases 4–5 were discharged from the intensive care unit and presented with severe chronic SJS. Most ocular manifestations improved significantly after symblepharon release and ProKera® insertion, except for corneal conjunctivalization in 1 eye (case 5). Case 6 involved early ProKera® use at the bedside during acute SJS, resulting in complete resolution. We concluded that the adjunctive application of ProKera® can be effective for ocular surface reconstruction and provides options to intervene earlier for outpatients or patients unstable for invasive surgical intervention.

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Section: Discussionmentioning

confidence: 91%

Self-Retained, Sutureless Amniotic Membrane Transplantation for the Management of Ocular Surface Diseases

Chiu,

Tsai

2023

JCM

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“…Some immune-related reactions manifest on the ocular surface, such as uncontrolled inflammation, dry eye disease, epithelial keratitis, stromal ulceration and corneal perforation. [ 14 ] Thomas et al [ 15 ] reported a case of an 88-year-old Caucasian man with metastatic melanoma, who was administered pembrolizumab at 2 mg/kg. After 24 months of pembrolizumab therapy, he developed corneal erosions, oral and genital ulcerations, a syndrome similar to Behcet disease.…”

Section: Discussionmentioning

confidence: 99%

Ornidazole induced Stevens–Johnson syndrome without body surface involved: A case report

Bai,

Wang,

Wang

et al. 2024

Medicine

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Rationale: Ornidazole is a synthetic nitroimidazole derivative that is commonly prescribed for antiparasitic or anti-anaerobic infections. It is generally well tolerated, with known side effects including gastrointestinal tract, anaphylaxis, and central nervous system reactions. Ornidazole-induced binocular reactive keratitis and several mucocutaneous lesions have been rarely reported. Patient concerns: A 52-year-old woman who suffered from vaginitis and received an ornidazole vaginal plug (0.5 g). Approximately 20 minutes after the suppository was inserted into the vagina, her lips were swollen and valva and labia were burning. Her eyes were red, sore, and watery. Diagnosis: She was diagnosed as Steven–Johnson syndrome by the ophthalmologist. According to the Naranjo scale, the adverse drug reaction was evaluated to be probable and severe. Interventions: Dexamethasone was intravenous administrated as anti-inflammatory therapy for 10 days. Eye drops were locally given to relieve edema and promote healing of the epithelium. The symptoms of her eyes, lips, vulva and crissum were soon relieved. Outcomes: The patient was discharge from hospital with improved symptoms. Lessons: In order to avoid severe adverse effect, the patient should not use metronidazole ether orally or vaginally. The case emphasized the importance of rapid and accurate diagnosis of Steven–Johnson syndrome induced by ornidazole vaginal plug, especially when the eye symptoms were the chief complaint without body skin involved.

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“…Articles related to conjunctivochalasis were included since the fornix may often be involved. Articles related to acute cicatrizing conjunctivitis, such as Stevens-Johnson syndrome were reviewed but not included in the summary as the literature has previously been comprehensively reviewed; 27,28 articles addressing the subacute and chronic pathology associated with cicatrizing conjunctivitis were included in the summary. A total of 62 articles were identified and included in the summary tables.…”

Section: Methodsmentioning

confidence: 99%

“…93 AMT placement for acute cicatrizing conjunctivitis has previously been reviewed and for this reason, a comprehensive summary of all articles was not included in this review paper. 27,28…”

Section: Eyelid and Fornixmentioning

confidence: 99%

A Review of Current Uses of Amniotic Membrane Transplantation in Ophthalmic Plastic and Reconstructive Surgery

Parikh,

Conger,

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To review and summarize the existing literature on the clinical applications of amniotic membrane transplantation (AMT) in ophthalmic plastic and reconstructive surgery. Methods: A literature review was conducted on the PubMed database using the following search terms: “amniotic membrane” and “eyelid” or “orbit” or “fornix” or “socket” or “lacrimal”. Results: In total 516 articles resulted from the search, of which 62 were included. Numerous cases and case series have been published on the use of amniotic membrane transplantation for ocular surface reconstruction, eyelid and forniceal reconstruction, and cicatricial eyelid abnormalities. Surgical methods of securing the graft vary. Few comparative studies exist; some show a similar or improved result when compared to oral mucous membrane grafting for certain indications. Conclusions: Amniotic membrane transplantation can be a useful tool for the oculoplastic surgeon when faced with a case requiring reconstruction of the posterior lamellae, particularly in patients without other graft donor sites available, and uses of AMT continue to expand. Additional studies directly comparing AMT to other reconstructive techniques would be helpful in choosing between the available surgical techniques and standardizing best practices.

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Update on the application of amniotic membrane in immune-related ocular surface diseases

Cited by 15 publications

References 77 publications

Self-Retained, Sutureless Amniotic Membrane Transplantation for the Management of Ocular Surface Diseases

Self-Retained, Sutureless Amniotic Membrane Transplantation for the Management of Ocular Surface Diseases

Ornidazole induced Stevens–Johnson syndrome without body surface involved: A case report

A Review of Current Uses of Amniotic Membrane Transplantation in Ophthalmic Plastic and Reconstructive Surgery

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