Update on the association of miR-149 rs2292832 C>T polymorphism with gastric cancer risk: A meta-analysis study of gastrointestinal cancers

Abstract

Objective: Single nucleotide polymorphisms in microRNAs are believed to affect the occurrence and progression of cancer by altering the expression and biological functions of microRNAs. Several studies investigated the role of the miR-149 rs2292832 C>T polymorphism on the risk of gastric cancer (GC), but got conflicting results. Methods: We performed a comprehensive and systematic search through the PubMed MEDLINE, Google Scholar, Science Direct, Scopus, CNKI, and Web of science, 8 studies were included in the meta-analysis to determine whether miR-149 rs2292832 C>T polymorphism contributed to the risk of GC. Results: Pooled data indicated that miR-149 rs2292832 C>T polymorphism was not associated with GC risk. In the stratified analysis by ethnicity, miR-149 rs2292832 C>T polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.27, 95% CI = 1.04–1.55, P heterogeneity = 0.18, P = .02), recessive model (OR = 1.44, 95% CI = 1.04–2.01, P heterogeneity = 0.19, P = .03) among Caucasians; but decreased GC risk under the allele comparison model (OR = 0.89, 95% CI = 0.81–0.98, P heterogeneity = 0.22, P = .02) and dominant model (OR = 0.82, 95% CI = 0.72–0.93, P heterogeneity = 0.15, P = .01) among Asian. Conclusion: Our meta-analysis suggests a positive correlation between miR-149 rs2292832 C>T polymorphism and GC development among Caucasians, but negative correlation among Asian population.

The association between XPD rs13181 and rs1799793 polymorphism and oral cancer risk: evidence from a meta-analysis

“…Additionally, the sample size was relatively small, though larger than in previous meta-analyses [ 9 , 21 ]. Although no publication bias was observed, positive results may be more likely to be published, potentially affecting the meta-analysis [ 20 ]. Despite these limitations, our study offers a comprehensive exploration of the relationship between XPD polymorphisms and oral cancer susceptibility.…”

“…Stratified analysis by ethnicity was also carried out. Statistical heterogeneity, funnel plots, sensitivity analysis, and publication bias were analyzed as previously described [20]…”

“…Stratified analysis by ethnicity was also carried out. Statistical heterogeneity, funnel plots, sensitivity analysis, and publication bias were analyzed as previously described [ 20 ]. All statistical tests for this meta-analysis were performed with Review Manager (RevMan) [Computer program].…”