Update on the natural history of cavernous malformations and factors predicting aggressive clinical presentation

Washington, Chad W.; McCoy, Kathleen E.; Zipfel, Gregory J.

doi:10.3171/2010.5.focus10149

Cited by 137 publications

(108 citation statements)

References 60 publications

(87 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…33 In this subpopulation asymptomatic hemorrhage rates were reported to be as high as 13% per patient-year. 35 This elevated rate increases the importance of identifying familial CMs perhaps with new MR imaging sequences such as susceptibilityweighted imaging.…”

Section: Risk Of Hemorrhagementioning

confidence: 90%

“…Earlier population studies retrospectively reviewing MR imaging documented symptomatic hemorrhage rates between 0.25% and 2.3% per patient-year and about 0.1%-1.4% per lesion-year. 9,28,33 However, many of these rates were calculated assuming that the CMs were present at birth, and the risk of hemorrhage was calculated considering a patient's entire lifespan. Prospective studies have demonstrated a rate of hemorrhage between 0.8% and 3.8% per patient-year.…”

Section: Risk Of Hemorrhagementioning

confidence: 99%

See 1 more Smart Citation

Management of incidental cavernous malformations: a review

Dalyai

Ghobrial

Awad

et al. 2011

FOC

View full text Add to dashboard Cite

Cavernous malformations (CMs) are angiographically occult vascular malformations that are frequently found incidentally on MR imaging. Despite this benign presentation, these lesions could cause symptomatic intracranial hemorrhage, seizures, and focal neurological deficits. Cavernomas can be managed conservatively with neuroimaging studies, surgically with lesion removal, or with radiosurgery. Considering recent studies examining the CM's natural history, imaging techniques, and possible therapeutic interventions, the authors provide a concise review of the literature and discuss the optimal management of incidental CMs.

show abstract

Section: Risk Of Hemorrhagementioning

confidence: 90%

Section: Risk Of Hemorrhagementioning

confidence: 99%

Management of incidental cavernous malformations: a review

Dalyai

Ghobrial

Awad

et al. 2011

FOC

View full text Add to dashboard Cite

show abstract

“…The number of patients presenting with hemorrhage ranges from 20 to 57% (8,9,26). The risk of bleeding is influenced by many factors as deep anatomical location, female sex, pregnancy, brain radiotherapy, familial and multiple form of disease (11,18,21,22).…”

Section: Discussionmentioning

confidence: 99%

“…MRI is used for the diagnosis, especially in T2 WI (6). The clinical presentation may vary from asymptomatic forms, estimated to be 2-32%, intracranial hemorrhage or seizures (1,(24)(25)(26).…”

mentioning

confidence: 99%

Multiple cavernomas of the brain: simultaneous hemorrhage of two lesions in a non-familial form

Panciani

Agnoletti²,

Fornaro³

et al. 2011

Turkish Neurosurgery

View full text Add to dashboard Cite

BackgrOund: Cavernomas of the brain are congenital lesions clinically divided into hereditary and a sporadic forms. Multiple lesions are usually observed in the familial form, whereas the sporadic variant generally shows a single cavernoma. In this case we describe the simultaneous bleeding of two lesions in a patient with a non-familial cavernomatosis.case descrIptIOn: A 46-year-old woman presented with slight hyposthenia involving the left arm and cervical stiffness. Examinations revealed two cavernomas with recent signs of bleeding. The lesions were surgically removed achieving a total excision. The patient was discharged after 10 days with slight left hyposthenia.dIscussIOn: Simultaneous hemorrhage of multiple cavernomas is rare. To the best of our knowledge, this is the first case showing a sporadic form presenting with two hemorrhagic lesions. We suggest an aggressive approach in order to avoid the risk of rebleeding, which is particularly high in case of hemorrhagic cavernomatosis.keywOrds: Hemangioma, Cavernous, Central nervous system, Hemorrhage, Familial cerebral cavernous malformation ÖZ aMaÇ: Beyin kavernomları klinik olarak herediter ve sporadik forma bölünen konjenital lezyonlardır. Multipl lezyonlar genellikle ailesel formda görülürken, sporadik varyantta genelde tek kavernom görülür. Bu olguda ailesel olmayan kavernomatosisi olan bir hastada iki lezyonda eş zamanlı kanama tanımlıyoruz.OLgu sunuMu: 46 yaşında bir kadın sol kolda hafif hiposteni ve servikal sertlikle geldi. Muayeneler yakın zamanlı kanama bulgularıyla iki kavernom gösterdi. Lezyonlar cerrahi olarak çıkarılıp tam eksizyon elde edildi. Hasta 10 gün sonra hafif bir sol hiposteniyle taburcu edildi. tartIşMa: Multipl kavernomların eş zamanlı kanaması nadirdir. Bildiğimiz kadarıyla bu hasta iki hemorajik lezyonla gelen ilk sporadik form olgusudur. Özellikle hemorajik kavernomatoz olgularında yüksek olan tekrar kanama riskinden kaçınmak için agresif bir yaklaşım öneriyoruz.anaHtar sÖZcÜkLer: Hemanjiyom, Kavernöz, Merkez sinir sistemi, Kanama, Ailesel serebral kavernöz malformasyon

show abstract

“…Developmental venous anomalies themselves have a very low risk of hemorrhage, with prospective series reporting a symptomatic hemorrhage rate as low as 0.3% [221]. They are, however, associated with the development of other vascular malformations (in particular cavernous malformation), which increase the risk of symptomatic hemorrhage to as high as 6% per year [227].…”

Section: Prognosismentioning

confidence: 99%