Update on the pathophysiology of the epilepsies

Ure, Jorge; Perassolo, Mónica

doi:10.1016/s0022-510x(00)00356-7

Cited by 31 publications

(16 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…, K ? ATPase (Ure and Perassolo 2000), GPx and GST (Kaur et al 2001(Kaur et al , 2003a in the brain which lends support to the present data. The results of the present study clearly showed that chronic aluminium treatment elevated the levels of lipid peroxidation and depressed the activities of SOD, GPx, GST in the brain cortex and hippocampus of 10-month-old as well as 24-month-old rats.…”

Section: Discussionsupporting

confidence: 90%

Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions

et al. 2008

View full text Add to dashboard Cite

This study investigated the effect of curcumin on aluminium-induced alterations in ageing-related parameters: lipid peroxidation, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST), protein kinase C (PKC), Na(+), K(+)-adenosine triphosphatase (Na(+), K(+)-ATPase) and acetylcholinesterase (AChE) in the cerebral cortex and hippocampus of the brain of 10- and 24-month-old rats. Measurements taken from aluminium-fed rats were compared with those from rats in which curcumin and aluminium were co-administered. In aluminium-treated rats the levels of lipid peroxidation, PKC and AChE were enhanced while the activities of SOD, GPx, GST and Na(+), K(+)-ATPase were significantly decreased in both the brain regions of both age-groups. In animals co-administered with curcumin and aluminium, the levels of lipid peroxidation, activities of PKC and AChE were significantly lowered while the activities of SOD, GPx, GST and Na(+), K(+)-ATPase were significantly enhanced in the two brain regions studied indicating curcumin's protective effects against aluminium toxicity. Though the magnitudes of curcumin-induced alterations varied in young and old animals, the results of the present study also demonstrated that curcumin exerts a protective effect against aluminium-induced elevation of ageing-related changes by modulating the extent of oxidative stress (by upregulating the activities of antioxidant enzymes) and by regulating the activities of Na(+), K(+) ATPase, PKC and AChE. Therefore, it is suggested that curcumin counters aluminium-induced enhancement in ageing-related processes.

show abstract

Section: Discussionsupporting

confidence: 90%

Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions

et al. 2008

View full text Add to dashboard Cite

show abstract

“…In addition, CA also increased Na + , K + -ATPase and d-aminolevulinic 49 acid dehydratase activities after seizures induced by P400, PIC or PTZ when compared with seizures 50 induced by P400, PIC or PTZ (p < 0.05), respectively. This study demonstrated that CA could be a future 51 therapeutic option for treatment of epilepsy, with a multifactorial brain action mechanism.…”

mentioning

confidence: 86%

“…On studying frontal 530 and temporal foci, Van Gelder and co-workers found a decrease 531 in aspartate in all the examined areas, and a decrease in glutamate 532 levels in excitable regions [48]. Conversely, another study reported 533 a 28% increase in aspartate concentration in surgical specimens 534 from patients with temporal epilepsy [48,49]. 535 Nevertheless, there are a greater number of studies showing the 536 tendency of animal in epilepsy models suffer an increase in GABA 537 levels when treated with anticonvulsant agents, which is in accor-538 dance with our results [46][47][48][49][50].…”

mentioning

confidence: 99%

Neuropharmacological effects of carvacryl acetate on δ-aminolevulinic dehydratase, Na+, K+-ATPase activities and amino acids levels in mice hippocampus after seizures

Pires

Costa

Almeida

et al. 2015

Chemico-Biological Interactions

View full text Add to dashboard Cite

Epileptic syndromes are highly prevalent neurological conditions and can often be disabling. In order to find an alternative for treatment, this study evaluated anticonvulsant effects of carvacryl acetate (CA), a derivative of monoterpene carvacrol, after seizures induced by pilocarpine (P400), picrotoxin (PIC) or pentylenetetrazol (PTZ). We also analyzed the CA effects on Na+, K+-ATPase and δ-aminolevulinic acid dehydratase (δ-ALA-D) activities in hippocampus mice after seizures induced by P400, PIC or PTZ. In addition, glutamate, δ-aminobutyric acid (GABA), glutamine and aspartate levels in mice hippocampus treated with CA after seizures induced by P400, PIC or PTZ were also measured. CA produced anticonvulsant effects against seizures induced by P400, PIC or PTZ, and its effects were reversed by flumazenil, suggesting that action mechanism can be mediated by GABAergic system. CA increased GABA levels, but did not alter glutamate and aspartate concentrations in mice hippocampus after seizures induced by P400, PIC or PTZ when compared with seizures induced by P400, PIC or PTZ (p<0.05), respectively, as well as decreased glutamine content in mice hippocampus after seizures induced by PIC when compared with seizures induced by PIC (p<0.05). In addition, CA also increased Na+, K+-ATPase and δ-aminolevulinic acid dehydratase activities after seizures induced by P400, PIC or PTZ when compared with seizures induced by P400, PIC or PTZ (p<0.05), respectively. This study demonstrated that CA could be a future therapeutic option for treatment of epilepsy, with a multifactorial brain action mechanism.

show abstract

“…About 20% of the epilepsy patients have seizures that are not adequately controlled by antiepileptic drugs (AEDs). It is commonly assumed that an imbalance between excitation and inhibition initiates seizure activity (2,3), although cellular and molecular mechanisms underlying epileptogenesis and maintenance of neuronal hyperexcitability during epileptic seizures are poorly understood. Moreover, changes in synaptic physiology induced by seizures may represent either adaptive or epileptogenic mechanisms.…”

mentioning

confidence: 99%

Epilepsy‐induced Changes in Signaling Systems of Human and Rat Postsynaptic Densities

et al. 2003

View full text Add to dashboard Cite

Summary:Purpose: To study seizure-induced changes in signaling proteins present in postsynaptic densities (PSDs) isolated from human epileptic neocortex and from rat cortex in which seizures were induced by injection of kainic acid.Methods: We performed Western blot analysis of signaling proteins in PSDs isolated from cortical tissue.Results: Seizures induce a strong upregulation of TrkB, the receptor for brain-derived neurotrophic factor (BDNF), whereas components of the N-methyl-D-aspartate (NMDA)-receptor complex are downregulated in both human and rat PSDs.Conclusions: These data show that long-term changes in PSD composition occur as a consequence of epileptic seizure activity.

show abstract

Update on the pathophysiology of the epilepsies

Cited by 31 publications

References 121 publications

Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions

Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions

Neuropharmacological effects of carvacryl acetate on δ-aminolevulinic dehydratase, Na+, K+-ATPase activities and amino acids levels in mice hippocampus after seizures

Epilepsy‐induced Changes in Signaling Systems of Human and Rat Postsynaptic Densities

Contact Info

Product

Resources

About