Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective

Friesen, Craig A.; Colombo, Jennifer; Schurman, Jennifer Verrill

doi:10.3390/nu13062056

Cited by 4 publications

(4 citation statements)

References 132 publications

(183 reference statements)

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“…Allergic reactions to food could occur through a variety of mechanisms, including IgE-mediated and non-IgE-mediated. 27 Fish allergy is usually an IgE-mediated type I hypersensitivity reaction. 28 There are two phases in allergic reactions: the sensitizing phase and the effector phase.…”

Section: Mechanisms Of Fish Allergymentioning

confidence: 99%

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Fish Allergy: A Review of Clinical Characteristics, Mechanism, Allergens, Epitopes, and Cross-Reactivity

Sun,

Luo,

Chen

et al. 2024

ACS Food Sci. Technol.

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Fish is one of eight foods that can cause severe allergic reactions. The growing consumption of fish and fish derivatives contributes to an increase in the incidence of fish allergies. Distinct regional variations in fish allergies are evident with higher prevalence rates observed in coastal countries, which may be related to the high consumption of local fish in these regions. The diagnostic methods of fish allergies include in vivo and in vitro detection, and the skin prick test is one of the most common screening methods. To date, several fish allergens have been identified, including parvalbumin, enolase, aldolase, collagen, and other allergens. Despite the homologous structure of parvalbumin from different fish species, variations in the IgE epitope may be one of the reasons leading to the complexity of fish allergies. To further understand the mechanisms of fish allergies, this review summarizes the recent literature and focuses on the clinical characteristics, mechanism, allergens, epitopes, and cross-reactivity.

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Section: Mechanisms Of Fish Allergymentioning

confidence: 99%

“…Allergic reactions to food could occur through a variety of mechanisms, including IgE-mediated and non-IgE-mediated . Fish allergy is usually an IgE-mediated type I hypersensitivity reaction .…”

Section: Mechanisms Of Fish Allergymentioning

confidence: 99%

Fish Allergy: A Review of Clinical Characteristics, Mechanism, Allergens, Epitopes, and Cross-Reactivity

Sun,

Luo,

Chen

et al. 2024

ACS Food Sci. Technol.

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“…IBS shares pathophysiologic features with allergies, including both immune and psychological patterns, even though the mechanism through which allergens might play a role in the determinism of IBS remains unclear. In the absence of systemic allergic symptoms or oral allergy syndrome, allergic triggers for IBS are unlikely to be identified by standard testing [ 107 ].…”

Section: Diagnosismentioning

confidence: 99%

Italian guidelines for the management of irritable bowel syndrome in children and adolescents

Di Nardo,

Barbara,

Borrelli

et al. 2024

Ital J Pediatr

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The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature and voting process on 22 statements on both diagnosis and management of IBS in children. Recommendations and levels of evidence were evaluated according to the grading of recommendations, assessment, development, and evaluation (GRADE) criteria. Consensus was reached for all statements. These guidelines suggest a positive diagnostic strategy within a symptom-based approach, comprehensive of psychological comorbidities assessment, alarm signs and symptoms’ exclusion, testing for celiac disease and, under specific circumstances, fecal calprotectin and C-reactive protein. Consensus also suggests to rule out constipation in case of therapeutic failure. Conversely, routine stool testing for enteric pathogens, testing for food allergy/intolerance or small intestinal bacterial overgrowth are not recommended. Colonoscopy is recommended only in patients with alarm features. Regarding treatment, the consensus strongly suggests a dietary approach, psychologically directed therapies and, in specific conditions, gut-brain neuromodulators, under specialist supervision. Conditional recommendation was provided for both probiotics and specific fibers supplementation. Polyethylene glycol achieved consensus recommendation for specific subtypes of IBS. Secretagogues and 5-HT4 agonists are not recommended in children with IBS-C. Certain complementary alternative therapies, antispasmodics and, in specific IBS subtypes, loperamide and rifaximin could be considered.

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“…An additional requirement for all FAPDs is that the symptoms are not, after careful evaluation, fully explained by any other medical condition [4]. The pathophysiology of FAPDs is obscure and considered multifactorial [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal Group Education for Children and Adolescents with Functional Abdominal Pain Disorders—A Feasibility Study of a Brief Intervention

Löfgren,

Lindfors,

Nilsson

et al. 2023

Gastrointestinal Disorders

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Functional abdominal pain disorders are common and disabling in children, but treatment options are limited. In a pilot study, we aimed to investigate if a brief group education program for pediatric patients with functional abdominal pain disorders and their parents is feasible and acceptable. Group education in adult irritable bowel syndrome has shown large treatment effects, but it has not been evaluated in children. The gastrointestinal (GI) group education, delivered in the clinic to 23 child–parent dyads, consisted of lectures by a pediatric gastroenterologist, a psychologist, and a dietician. Validated digital questionnaires were filled in by children and parents before and after the intervention. Most participants in the GI group education attended all sessions, and credibility in treatment was deemed high. Children’s self-reported knowledge of functional abdominal pain disorders increased, and improvements in gastrointestinal symptoms were reported at the end of this study. Our findings indicate that group education for children and adolescents with functional abdominal pain disorders, and their parents, is acceptable and feasible and may improve symptoms. A brief group education program may be of benefit in the management of pediatric functional abdominal pain disorders in several cases and when the family needs more knowledge than can be provided in primary care.

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Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective

Cited by 4 publications

References 132 publications

Fish Allergy: A Review of Clinical Characteristics, Mechanism, Allergens, Epitopes, and Cross-Reactivity

Fish Allergy: A Review of Clinical Characteristics, Mechanism, Allergens, Epitopes, and Cross-Reactivity

Italian guidelines for the management of irritable bowel syndrome in children and adolescents

Gastrointestinal Group Education for Children and Adolescents with Functional Abdominal Pain Disorders—A Feasibility Study of a Brief Intervention

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