Update on topical antibiotics in dermatology

Drucker, Carol R.

doi:10.1111/j.1529-8019.2012.01493.x

Cited by 48 publications

(21 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most frequently prescribed topical antibiotic is mupirocin which is similar to the study by Khan et al 33 and is in favor of Drucker 34 who has mentioned that mupirocin ointment has activity against S. pyogenes, both methicillin sensitive S. aureus and methicillin resistant S. aureus and is bactericidal at concentrations achieved by topical applications.…”

Section: Discussionmentioning

confidence: 52%

Study on drug utilization pattern of antibiotics among dermatology in-patients of a tertiary care teaching hospital, Karaikal, Puducherry

Divyashanthi

Nandhini²,

Kumar

2014

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 52%

Study on drug utilization pattern of antibiotics among dermatology in-patients of a tertiary care teaching hospital, Karaikal, Puducherry

Divyashanthi

Nandhini²,

Kumar

2014

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

“…• Principles for the use of topical and systemic antibiotics/antimicrobials are summarized in Table 5[8,41,56]. …”

Section: Care Of the Eb Newborn And Infantmentioning

confidence: 99%

Multicentre consensus recommendations for skin care in inherited epidermolysis bullosa

Hachem

Zambruno

Bourdon-Lanoy

et al. 2014

Orphanet J Rare Dis

149

136

View full text Add to dashboard Cite

BackgroundInherited epidermolysis bullosa (EB) comprises a highly heterogeneous group of rare diseases characterized by fragility and blistering of skin and mucous membranes. Clinical features combined with immunofluorescence antigen mapping and/or electron microscopy examination of a skin biopsy allow to define the EB type and subtype. Molecular diagnosis is nowadays feasible in all EB subtypes and required for prenatal diagnosis. The extent of skin and mucosal lesions varies greatly depending on EB subtype and patient age. In the more severe EB subtypes lifelong generalized blistering, chronic ulcerations and scarring sequelae lead to multiorgan involvement, major morbidity and life-threatening complications. In the absence of a cure, patient management remains based on preventive measures, together with symptomatic treatment of cutaneous and extracutaneous manifestations and complications. The rarity and complexity of EB challenge its appropriate care. Thus, the aim of the present study has been to generate multicentre, multidisciplinary recommendations on global skin care addressed to physicians, nurses and other health professionals dealing with EB, both in centres of expertise and primary care setting.MethodsAlmost no controlled trials for EB treatment have been performed to date. For this reason, recommendations were prepared by a multidisciplinary team of experts from different European EB centres based on available literature and expert opinion. They have been subsequently revised by a panel of external experts, using an online-modified Delphi method to generate consensus.ResultsRecommendations are reported according to the age of the patients. The major topics treated comprise the multidisciplinary approach to EB patients, global skin care including wound care, management of itching and pain, and early diagnosis of squamous cell carcinoma. Aspects of therapeutic patient education, care of disease burden and continuity of care are also developed.ConclusionThe recommendations are expected to be useful for daily global care of EB patients, in particular in the community setting. An optimal management of patients is also a prerequisite to allow them to benefit from the specific molecular and cell-based treatments currently under development.

show abstract

“…The success of a surgery is often judged by the appearance of a scar, which may lead to numerous cosmetic and psychological consequences for the patient, including anxiety, self-consciousness, and low self-esteem [1]. Current recommendations for postoperative wound care following Mohs and other dermatological surgery include the application of white petrolatum or a topical antibiotic to the closed incision site before covering the wound with a dressing in order to create a moist healing environment [2, 3]. In recent years, studies have questioned the benefit of topical antibiotics in lieu of white petrolatum in reducing the incidence of postoperative wounds or leading to a more positive cosmetic outcome [2].…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study to Investigate the Efficacy of Tobramycin–Dexamethasone Ointment in Promoting Wound Healing

Andrew

Luecke

Dozier

et al. 2012

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

IntroductionThe standard postsurgical treatment of wounds after dermatologic procedures is currently limited. Topical corticosteroids have been used successfully in postoperative management of ophthalmologic surgeries that involve the skin of the eyelid. In particular, tobramycin 0.3%/dexamethasone 0.1% ophthalmic ointment is considered the “gold standard” of steroid-antibiotic fixed combinations and is marketed worldwide as an agent used to control postsurgical inflammation and prevent postsurgical infection. The purpose of this study is to evaluate both the efficacy and safety of tobramycin–dexamethasone ointment for the postsurgical management of Mohs or dermatologic surgery in comparison to white petrolatum.MethodsThe authors employed a half-scar study in which patients who underwent skin cancer removal surgery were given tobramycin–dexamethasone ointment and white petrolatum to apply to each half of their wound for 2 weeks. The study was double blinded, and physicians and the patients independently evaluated the scars for cosmetic appearance at 2 and 6 weeks postoperatively. The evaluation criteria included judging which side of the wound looked better based on color, thickness, and discomfort.ResultsEighteen patients were enrolled, of which 13 patients completed the three phases of the study. After 6 weeks the wounds did not show a statistically significant difference in color, thickness, or discomfort on either side.ConclusionResults obtained to date suggest that the application of tobramycin–dexamethasone ointment to wounds after dermatologic surgery does not promote better wound healing than white petrolatum. These findings indicate that a topical steroid and antibiotic ointment may not be an effective intervention in improving postoperative outcomes in dermatologic surgeries.

show abstract

Update on topical antibiotics in dermatology

Cited by 48 publications

References 37 publications

Study on drug utilization pattern of antibiotics among dermatology in-patients of a tertiary care teaching hospital, Karaikal, Puducherry

Study on drug utilization pattern of antibiotics among dermatology in-patients of a tertiary care teaching hospital, Karaikal, Puducherry

Multicentre consensus recommendations for skin care in inherited epidermolysis bullosa

A Pilot Study to Investigate the Efficacy of Tobramycin–Dexamethasone Ointment in Promoting Wound Healing

Contact Info

Product

Resources

About