Update on Treatments for Endotoxemia

Kelmer, Gal

doi:10.1016/j.cveq.2009.04.012

Cited by 32 publications

(27 citation statements)

References 67 publications

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“…Haptoglobin products have also been used in patients with different diseases to prevent haem-induced oxidative damage (Schaer et al, 2013). A similar approach has been proposed in equine colic, and treatments targeting cytokines, oxidative stress, endotoxaemia and the immune system have been studied with potentially promising results (Kelmer, 2009). The APR itself and its systemic effects, such as tissue damage, perfusion impairment, oxidative stress, or even haemolysis may be used as therapeutic targets in the future management of horses with colic.…”

Section: Discussionmentioning

confidence: 98%

Serum amyloid A, haptoglobin, and ferritin in horses with colic: Association with common clinicopathological variables and short-term outcome

Dondi

Lukacs

Gentilini

et al. 2015

The Veterinary Journal

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Section: Discussionmentioning

confidence: 98%

Serum amyloid A, haptoglobin, and ferritin in horses with colic: Association with common clinicopathological variables and short-term outcome

Dondi

Lukacs

Gentilini

et al. 2015

The Veterinary Journal

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“…18 Circulating endotoxins have been reportedly measured in 25-41% of colic horses and signs of endotoxemia are frequently recognized clinically both before and after surgery, suggesting that this may be linked to hyperlactatemia in this population. 19,20 Intraoperatively, arterial blood pressure, venous stasis, and length of procedure have been linked to postoperative myopathy, in which decreased perfusion leads to muscle damage. 21 A previous study that reported insufficient muscle oxygenation during anesthesia in colic horses suggested that the increased lactate production from anaerobic metabolism in the muscles was trapped during anesthesia, resulting in increased muscle lactate, but steady plasma lactate.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Gas Exchange and Plasma Lactate in Horses with Gastrointestinal Disease Undergoing Emergency Exploratory Laparotomy: A Comparison with an Elective Surgery Horse Population

McCoy¹,

Hackett²,

Wagner³

et al. 2011

Veterinary Surgery

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“…The stimulation of TLR4 activates the genes responsible for production of proinflammatory mediators. 2 In some cases, steroids and nonsteroidal anti-inflammatory drugs can mask the clinical signs of endotoxemia, delaying the decision for surgery. 3 In addition, these drugs exert obvious adverse effects even within their therapeutic range.…”

mentioning

confidence: 99%

Effects of Lidocaine Infusion during Experimental Endotoxemia in Horses

Peiró

Barnabé

Cadioli

et al. 2010

Journal of Veterinary Internal Medicine

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Background:The clinical efficacy of IV infusion of lidocaine for treatment of equine endotoxemia has not been studied. Hypothesis: Lidocaine infusion after exposure to lipopolysaccharide (LPS) will inhibit the inflammatory response and have inhibitory effects on the hemodynamic and cytokine responses to endotoxemia.Animals: Twelve horses. Methods: Two equal groups (n 5 6): saline (GI) and lidocaine (GII). In all animals, endotoxin (500 ng/kg body weight [BW]) was injected intraperitoneally over 5 minutes. Twenty minutes later, animals received a bolus of GI or GII (1.3 mg/kg BW) over 5 minutes, followed by a 6-hour continuous rate infusion of GI or GII (0.05 mg/kg BW/min). Treatment efficacy was judged from change in arterial blood pressure, peripheral blood and peritoneal fluid (PF) variables (total and differential cell counts, enzyme activities, and cytokine concentrations), and clinical scores (CS) for behavioral evidence of abdominal pain or discomfort during the study.Results: Compared with the control group, horses treated with lidocaine had significantly lower CS and serum and PF tumor necrosis factor-a (TNF-a) activity. At several time points in both groups, total and differential cell counts, glucose, total protein and fibrinogen concentrations, and alkaline phosphatase, creatine kinase, and TNF-a activities were significantly different from baseline values both in peripheral blood and in PF.Conclusions and Clinical Importance: Lidocaine significantly decreased severity of CS and inhibited TNF-a activity in PF.

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Update on Treatments for Endotoxemia

Cited by 32 publications

References 67 publications

Serum amyloid A, haptoglobin, and ferritin in horses with colic: Association with common clinicopathological variables and short-term outcome

Serum amyloid A, haptoglobin, and ferritin in horses with colic: Association with common clinicopathological variables and short-term outcome

Pulmonary Gas Exchange and Plasma Lactate in Horses with Gastrointestinal Disease Undergoing Emergency Exploratory Laparotomy: A Comparison with an Elective Surgery Horse Population

Effects of Lidocaine Infusion during Experimental Endotoxemia in Horses

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