Update on Ultrasound Diagnosis for Thyroid Cancer

Baig, FN; Liu, Syw; Yip, SP; Law, Hkw; Ying, Michael

doi:10.12809/hkjr1816960

Cited by 5 publications

(5 citation statements)

References 64 publications

(110 reference statements)

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“…Bojunga found in his review that elastography was predominantly useful as a negative predictor for malignancy (a high NPV 93%–99%) 32 . Baig et al also describes elastography as an adjunct to standard‐ and Doppler imaging and emphasizes the need for larger studies to study its effects 100 . Du et al found that elastography combined with a RSS was superior to using only the RSS for differentiating small thyroid nodules 101 .…”

Section: Diagnosismentioning

confidence: 99%

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Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends

Boers

Braak

Rikken

et al. 2023

J of Clinical Ultrasound

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Ultrasound, the primary imaging modality in thyroid nodule management, suffers from drawbacks including: high inter-and intra-observer variability, limited field-of-view and limited functional imaging. Developments in ultrasound technologies are taking place to overcome these limitations, including three-dimensional-Doppler, -elastography, -nodule characteristics-extraction, and novel machine-learning algorithms. For thyroid ablative treatments and biopsies, perioperative use of three-dimensional ultrasound opens a new field of research. This review provides an overview of the current and future applications of ultrasound, and discusses the potential of new developments and trends that may improve the diagnosis, therapy, and follow-up of thyroid nodules.

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Section: Diagnosismentioning

confidence: 99%

“…32 Baig et al also describes elastography as an adjunct to standard-and Doppler imaging and emphasizes the need for larger studies to study its effects. 100 Du et al found that elastography combined with a RSS was superior to using only the RSS for differentiating small thyroid nodules. 101 Aghaghazvini et al…”

Section: Future Trends-tissue Characteristicsmentioning

confidence: 99%

Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends

Boers

Braak

Rikken

et al. 2023

J of Clinical Ultrasound

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“…A thyroid nodule (TN) is a mass of solid, fluid-filled, or a combination of the two that develops from aberrant growths of thyroid cells within the thyroid gland. TNs are prevalent, affecting 20% to 76% of the population [1]. The incidence of TNs have been measured at 2-6% by physical examination, 19-35% by imaging, and 8%-65% by autopsy [2].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of Ultrasonography Using U Classification of Thyroid Nodules in Detection of Malignant Thyroid

Qurat Ul Ain,

Bibi

2023

j.teknokes

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Ultrasonography (US) helps diagnose malignant thyroid nodules based on various characteristics, including echogenicity, margins, microcalcifications, size, form, and aberrant neck lymph nodes. The study aimed to determine the diagnostic accuracy of ultrasonography for cancer diagnosis in thyroid nodules, using Histopathology as the gold standard. To minimize morbidity and death from the condition and the number of solely invasive procedures biopsies, the results of our research will give patients and physicians with a noninvasive, cost-effective, and conveniently accessible diagnostic technique for differentiating cancerous from benign nodules. A cross-sectional analytical study was designed to collect data prospectively from July 2022 to October 2022 in the Department of Radiology at Nuclear Medicine, Oncology and Radiotherapy Institute Islamabad. Patients in the age range of 18-60 years, both genders were enrolled. Th data was entered into SPSS 24. The frequencies and percentages of categorical factors such as sex and malignancy in thyroid nodules were determined using descriptive analysis. For numerical variables such as age, the mean and standard deviation were computed. We evaluated the sensitivity, specificity, PPV, and NPV with a 95% confidence interval for the U-classification of malignant thyroid nodules and represented as Two by Two tables. In addition, Histopathology was used to evaluate U's efficacy as a diagnostic tool for finding malignant thyroid nodules. The study sample comprised 34 (68%) female and 16 (32%) male patients. On Biopsy, cancerous nodules were diagnosed in only 19 (38.5%) patients, and the remaining 31 (62%) had benign lesions. The prevalence of thyroid malignancy in our sample was 38%. On ultrasonography, malignancy was diagnosed in 15(30%) lesions, while the remaining 35(70%) patients were diagnosed with benign lesions. Histopathology confirmed malignant thyroid nodules in 15 (true positive) cases, whereas 6 (false positive) had no malignant lesion on Histopathology. In US negative patients, 27 were true negative, while 2 were false negative. The sensitivity of ultrasound U-score in diagnosing malignant thyroid nodules was 88.2%, specificity was 81.8%, PPV was 71.4%, and NPV was 93% Diagnostic accuracy is high when the US is used to detect thyroid problems, making it the preferred noninvasive technique. We recommend that thyroid lesions be routinely assessed clinically, imaged radiographically, and analyzed histo-pathologically. U Classification system for identifying potentially cancerous thyroid nodules is a valuable tool. It allows for a more prudent choice of nodules to undergo FNAC, reducing the number of needless procedures.

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“…Thyroid nodules (TNs) are abnormal growths of thyroid cells that form solid, fluid-filled, or mixed masses within the thyroid gland. TNs are common and are found in 20% to 76% of the population 1. The prevalence of TNs has been reported to be 2-6% with palpation, 19-35% with US, and 8%-65% on autopsy 2.…”

Section: Introductionmentioning

confidence: 99%

“…US is the first-line imaging modality used to identify and characterize TNs. Gray-scale ultrasonography (GSU) imaging features of TNs are reliable in differentiating benign from malignant nodules 1,7. The elastic properties of TNs showed malignant nodules to be stiffer than benign nodules and this held out the promise of discrimination between benign and malignant nodules with higher diagnostic accuracy than GSU 1,8…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of ultrasonography versus fine-needle-aspiration cytology for predicting benign thyroid lesions

Alshoabi

Binnuhaid

2019

Pak J Med Sci

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Background and Objective: Thyroid nodules (TNs) are abnormal growths of thyroid cells that form masses within the thyroid gland. TNs are common, and the importance lies in need to exclude thyroid cancer. This study was intended to evaluate the diagnostic accuracy of ultrasonography for differentiating benign from malignant thyroid lesions in comparison with fine-needle aspiration cytology (FNA cytology). Methods: This study involved 133 patients with thyroid lesions. All patients underwent thyroid ultrasonography and ultrasound (US)-guided-FNA cytology and results were compared. Results: Out of 133 patients included in this study, the mean age was 41.2±15 years, and 113 (85%) were female. Thyroid lesions were benign in 126 cases (94.7%) and malignant in nine cases (5.3%). Among 124 patients with thyroid lesions diagnosed as benign with US, 122 (98.38%) were confirmed to be benign with FNA cytology, and only 2 (1.6%) were proved to be malignant. Among nine patients with thyroid lesions diagnosed as malignant by US, 5 (55.6%) were confirmed to be malignant by FNA cytology, and 4 (44.4%) were proved to be benign. The US diagnosed benign thyroid lesions with a sensitivity, specificity, positive predictive value, and negative predictive value of 98.38%, 71.42%, 98.38%, and 55.55%, respectively. The results revealed strong compatibility between diagnosis of benign thyroid lesions by the US and proved diagnosis by FNA cytology (p<0.001). Conclusion: B-mode ultrasonography is a valuable tool in differentiating benign from malignant thyroid lesions. It can almost always predict the benign nature of thyroid lesions with excellent diagnostic accuracy. doi: https://doi.org/10.12669/pjms.35.3.292 How to cite this:Alshoabi SA, Binnuhaid AA. Diagnostic accuracy of ultrasonography versus fine-needle-aspiration cytology for predicting benign thyroid lesions. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.292 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Update on Ultrasound Diagnosis for Thyroid Cancer

Cited by 5 publications

References 64 publications

Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends

Ultrasound imaging in thyroid nodule diagnosis, therapy, and follow‐up: Current status and future trends

Diagnostic Accuracy of Ultrasonography Using U Classification of Thyroid Nodules in Detection of Malignant Thyroid

Diagnostic accuracy of ultrasonography versus fine-needle-aspiration cytology for predicting benign thyroid lesions

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