Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the 'long-haulers'

Vehar, Susan; Ntiamoah, Prince; Biehl, Michelle

doi:10.3949/ccjm.88a.21010-up

Cited by 7 publications

(16 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some studies have shown persistence of at least one symptom in more than half of patients at 110-day follow-up. 3 PASC can even affect young adults who experienced mild symptoms during infection and did not require hospitalization for COVID-19; PASC also can manifest in children, many of whom had asymptomatic COVID-19 infections. 8 Although COVID-19 and PASC are still relatively new phenomena, they have shown similarities to other welldocumented viral respiratory illnesses, such as Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), which caused similar postviral disorders including ME/CFS.…”

Section: Learning Objectivesmentioning

confidence: 99%

“…The duration of PASC is unknown and will be defined over time with additional studies. Some studies have shown persistence of at least one symptom in more than half of patients at 110-day follow-up 3. PASC can even affect young adults who experienced mild symptoms during infection and did not require hospitalization for COVID-19; PASC also can manifest in children, many of whom had asymptomatic COVID-19 infections 8.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Emerging research on postacute COVID-19 complications

Williams

2023

Jaapa

View full text Add to dashboard Cite

show abstract

Section: Learning Objectivesmentioning

confidence: 99%

mentioning

confidence: 99%

Emerging research on postacute COVID-19 complications

Williams

2023

Jaapa

View full text Add to dashboard Cite

show abstract

“…From these studies, it is clear that mindfulness meditation has been associated with a number of healthy inflammatory process changes. 2 Seated meditation has been related to sympathetic nervous system reductions in activation. 48,69,73 The studies that have been reviewed have also found positive meditation on immune cell subsets related to the immune systems.…”

Section: Anti-inflammatory Effects Associated With Meditationmentioning

confidence: 99%

“…From these studies, it is clear that mindfulness meditation has been associated with a number of healthy inflammatory process changes. 2 …”

Section: Anti-inflammatory Effects Associated With Meditationmentioning

confidence: 99%

See 1 more Smart Citation

Mindfulness Meditation Interventions for Long COVID: Biobehavioral Gene Expression and Neuroimmune Functioning

Porter¹,

Jason²

2022

NDT

View full text Add to dashboard Cite

Some individuals infected with SARS CoV-2 have developed Post-Acute Sequelae of SARS CoV-2 infection (PASC) or what has been referred to as Long COVID. Efforts are underway to find effective treatment strategies for those with Long COVID. One possible approach involves alternative medical interventions, which have been widely used to treat and manage symptoms of a variety of medical problems including post-viral infections. Meditation has been found to reduce fatigue and unrefreshing sleep, and for those with post-viral infections, it has enhanced immunity, and reduced inflammatory-driven pathogenesis. Our article summarizes the literature on what is known about mindfulness meditation interventions, and reviews evidence on how it may apply to those with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Evidence is reviewed suggesting effective and sustainable outcomes may be achieved for symptomatology and underlying pathology of post-viral fatigue (PASC and ME/CFS).

show abstract

Persistent serum protein signatures define an inflammatory subcategory of long COVID

et al. 2023

View full text Add to dashboard Cite

Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The aetiologies may include persistent inflammation, unresolved tissue damage or delayed clearance of viral protein or RNA, but the biological differences they represent are not fully understood. Here we evaluate the serum proteome in samples, longitudinally collected from 55 PASC individuals with symptoms lasting ≥60 days after onset of acute infection, in comparison to samples from symptomatically recovered SARS-CoV-2 infected and uninfected individuals. Our analysis indicates heterogeneity in PASC and identified subsets with distinct signatures of persistent inflammation. Type II interferon signaling and canonical NF-κB signaling (particularly associated with TNF), appear to be the most differentially enriched signaling pathways, distinguishing a group of patients characterized also by a persistent neutrophil activation signature. These findings help to clarify biological diversity within PASC, identify participants with molecular evidence of persistent inflammation, and highlight dominant pathways that may have diagnostic or therapeutic relevance, including a protein panel that we propose as having diagnostic utility for differentiating inflammatory and non-inflammatory PASC.

show abstract

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the 'long-haulers'

Cited by 7 publications

References 18 publications

Emerging research on postacute COVID-19 complications

Emerging research on postacute COVID-19 complications

Mindfulness Meditation Interventions for Long COVID: Biobehavioral Gene Expression and Neuroimmune Functioning

Persistent serum protein signatures define an inflammatory subcategory of long COVID

Contact Info

Product

Resources

About