Updated Clinical Evidence on the Role of Adipokines and Breast Cancer: A Review

Verras, Georgios-Ioannis; Tchabashvili, Levan; Chlorogiannis, Dimitrios; Mulita, Francesk; Αργέντου, Μαρία-Ιωάννα

doi:10.3390/cancers15051572

Cited by 16 publications

(14 citation statements)

References 70 publications

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“…These results are in accordance with previous studies, in which circulating systemic inflammatory markers were found to be poor prognosis indicators in breast cancer patients. 34,35 Furthermore, we observed marked protective effects of anti-T. gondii IgG on breast cancer prognosis among women with a higher cytokine score than those with a lower score, a significant interaction (mainly contributed by IL-17 and IL-9). Patients with a high cytokine score might experience systemic inflammation, which induces angiogenesis, 36 a wellestablished driver of breast cancer aggressiveness and poor prognosis, 37 yet T. gondii infection inhibits angiogenesis.…”

mentioning

confidence: 69%

Beneficial Effect of Toxoplasma gondii Infection on the Prognosis of Breast Cancer Was Modified by Cytokines

Ye¹,

Lu²,

Liu³

et al. 2023

CLEP

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Background: Animal experiments have shown the anticancer activity of Toxoplasma gondii (T. gondii), but its effect on the prognosis of cancer patients is unclear. Thus, the present study aimed to investigate the prognostic role of anti-T. gondii IgG in breast cancer patients and the modification effect of cytokines. Methods: A total of 1121 breast cancer patients were recruited between 2008 and 2018 and followed up until December 31, 2021. Anti-T. gondii IgG and cytokines were measured using an enzyme-linked immunosorbent assay (ELISA) kit and a multiplex assay platform. Endpoints were overall survival (OS) and progression-free survival (PFS). Survival and multiplicative interaction analyses were performed using multivariate Cox regression models. Results: According to the cutoff value of optical density (OD=0.111), 900 (80.29%) and 221 (19.71%) patients were divided into two groups: low or high anti-T. gondii IgG. Compared to patients with a low anti-T. gondii IgG level, the adjusted hazard ratios (HRs) of OS and PFS for patients with high anti-T. gondii IgG levels were 0.60 (95% confidence interval (CI): 0.37-0.99) and 0.67 (0.46-0.98), respectively. These associations were profound among patients with a high cytokine score (HR=0.29, 95% CI: 0.10-0.82 for OS; HR=0.30, 95% CI: 0.13-0.69 for PFS), accompanied by a significant interaction between the level of anti-T. gondii IgG and the cytokine score (P interaction =0.019 for PFS); interleukin-17 (IL-17) and interleukin-9 (IL-9) were the main contributors to the interaction. Conclusion: Anti-T. gondii IgG was found to be beneficial to breast cancer survival, especially in women with systematic inflammation and high IL-17 or IL-9 levels, suggesting the potential of T. gondii as a prognostic marker and a novel immunotherapy approach for cancer patients.

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mentioning

confidence: 69%

Beneficial Effect of Toxoplasma gondii Infection on the Prognosis of Breast Cancer Was Modified by Cytokines

Ye¹,

Lu²,

Liu³

et al. 2023

CLEP

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“…31 Research also indicated that adipokines were related to proliferation, invasion, and metastasis of breast cancer cells, and were also associated with the prognosis of breast cancer. 32 Moreover, it is important to note that breast cancer patients with liver metastasis exhibited drug resistance and eventually develop resistance to systemic chemotherapy, endocrine therapy, and targeted therapy. [33][34][35][36] Nevertheless, study had performed that the survival time for breast cancer patients with liver metastasis is only 4-8 months without treatment.…”

Section: Discussionmentioning

confidence: 99%

The Age-Male-Albumin-Bilirubin-Platelets (aMAP) Risk Score Predicts Liver Metastasis Following Surgery for Breast Cancer in Chinese Population: A Retrospective Study

Chen,

Liu,

Tan

et al. 2024

ITT

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Objective The current study is conducted to investigate the potential prognostic value of the age-male-albumin-bilirubin-platelets (aMAP) score in breast cancer patients with liver metastasis after surgery. Methods This is a retrospective study of 178 breast cancer patients who developed liver metastasis after surgery. These patients were treated and followed up from 2000 to 2018 at our hospital. The aMAP risk score was estimated in accordance with the following formula: . The optimal cutoff value of the aMAP was evaluated via X-tile. Kaplan-Meier, Log-rank and Cox proportional hazards regression models were applied to determine the clinical influence of the aMAP score on the survival outcomes. The nomogram models were established by multivariate analyses. The calibration curves and decision curve analysis were applied to evaluate the estimated performance of the nomogram models. Results A total of 178 breast cancer patients were divided into low aMAP score group (<47.6) and high aMAP score group (≥47.6) via X-tile plots. The aMAP score was a potential prognostic factor in multivariate analysis. The median disease free survival (p=0.0013) and overall survival (p=0.0003) in low aMAP score group were longer than in high aMAP score group. The nomograms were constructed to predict the DFS with a C-index of 0.722 (95% CI, 0.673–0.771), and the OS with a C-index of 0.708 (95% CI, 0.661–0.755). The aMAP-based nomograms had good predictive performance. Conclusion The aMAP score is a potential prognostic factor in breast cancer with liver metastasis after surgery. The aMAP score-based nomograms were conducive to discriminate patients at high risks of liver metastasis and develop adjuvant treatment and prevention strategies.

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“…Taking into account that 31.7% of our patients were diagnosed with HL (important predominance compared with the other diagnoses), along with the fact that there was an important activation of brown fat identified in these patients (high SUV max (LBM) values), we may consider that BAT could potentially play a role in the development of cancer itself. Preceding research reported that breast cancer has been associated with an increase in a variety of circulating BATokines [32]. These adipokines stimulate many pathways that aid in the development and hallmarks of this type of malignancy [32].…”

Section: Discussionmentioning

confidence: 99%

“…Preceding research reported that breast cancer has been associated with an increase in a variety of circulating BATokines [32]. These adipokines stimulate many pathways that aid in the development and hallmarks of this type of malignancy [32].…”

Section: Discussionmentioning

confidence: 99%

Off the Beaten Path in Oncology: Active Brown Adipose Tissue by Virtue of Molecular Imaging

Jalloul,

Moscalu,

Moscalu

et al. 2023

CIMB

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Brown Adipose Tissue (BAT) is considered beneficial in diabetes and obesity, but it can also have negative effects such as its implication in tumours’ pathogenesis and the development of Cancer-induced Cachexia. Since 18F-FDG PET/CT is a common molecular imaging modality used in cancer assessment, we aim to study the 18F-FDG BAT biodistribution in oncological patients and look for possible correlations between BAT activity and different malignancies as well as the patient’s weight status. After analysing the total number of oncological 18F-FDG PET/CT scans between 2017 and 2021, we selected patients with active BAT. Based on their BMI, the selected patients were divided into nonobese (NO) vs. overweight and obese (OOB). OOB SUVmaxlean body mass(LBM) had the highest mean values in supraclavicular, latero-cervical, and paravertebral vs. mediastinal and latero-thoracic localisations in NO. BMI was positively correlated with latero-cervical and supraclavicular SUVmax(LBM) but negatively correlated with latero-thoracic and abdominal SUVmax(LBM). Considering the age of the patients, SUVmax(LBM) decreases in the latero-cervical, paravertebral, and abdominal regions. In addition, the males presented lower SUVmax(LBM) values. SUVmax(LBM) was not affected by the treatment strategy or the oncological diagnosis. To conclude, it is mandatory to take into consideration the BAT particularities and effects on weight status in order to optimise the clinical management of oncological patients.

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Updated Clinical Evidence on the Role of Adipokines and Breast Cancer: A Review

Cited by 16 publications

References 70 publications

Beneficial Effect of Toxoplasma gondii Infection on the Prognosis of Breast Cancer Was Modified by Cytokines

Beneficial Effect of Toxoplasma gondii Infection on the Prognosis of Breast Cancer Was Modified by Cytokines

The Age-Male-Albumin-Bilirubin-Platelets (aMAP) Risk Score Predicts Liver Metastasis Following Surgery for Breast Cancer in Chinese Population: A Retrospective Study

Off the Beaten Path in Oncology: Active Brown Adipose Tissue by Virtue of Molecular Imaging

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