Updated meta-analysis of the relation between heart disease and androgenic alopecia or alopecia areata

Amamoto, Misato; Yamada, Tomohide; Hara, Kazuo

doi:10.21767/amj.2017.3270

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…However, no differences were observed in cardiovascular risk between AA patients and controls in a previous cohort study [ 8 ]. Recently, a meta-analysis conducted by Amamoto et al [ 20 ] reported that AA was not related to HDs (relative risk: 0.91; 95% CI: 0.60–1.39; p = 0 . 66 ).…”

Section: Discussionmentioning

confidence: 99%

Alopecia areata is not a risk factor for heart diseases: A 10-year retrospective cohort study

2021

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Alopecia areata (AA) is an autoimmune skin disease caused by chronic inflammation of hair follicles. Chronic inflammatory skin diseases such as psoriasis and lupus erythematosus can increase the risk of cardiovascular diseases. However, the relationship between AA and heart diseases (HDs) remains unclear. Therefore, we conducted this retrospective cohort study to evaluate the risk of subsequent HDs in patients with AA. We reviewed 3770 cases of AA and from 18,850 age, sex, and income level-matched controls from the National Health Insurance Service-National Sample Cohort. In the subgroup analysis, patients who suffered from alopecia totalis, alopecia universalis, and ophiasis were designated as patients with severe AA and patients having the disease for over a year were designated as patients with long-standing AA. As a result, we found that AA was not associated with a higher risk of heart failure, angina pectoris, or myocardial infarction. There was no significant increase in the risk of overall HD associated with AA (adjusted hazard ratio: 1.17; 95% confidence interval: 0.93–1.48; p = 0.177). Neither the severity nor the duration of AA was related to an increased risk of HDs. During the study period, AA patients did not show a significantly higher cumulative incidence of HDs than controls (log-rank p = 0.157). In conclusion, AA does not increase the risk of HD.

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Section: Discussionmentioning

confidence: 99%

Alopecia areata is not a risk factor for heart diseases: A 10-year retrospective cohort study

2021

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“…Several studies have reported an association between AGA and cardiovascular risk [ 60 ]. Amamoto Misato et al screened a total of nine studies (eight on AGA, one alopecia areata: 44,806 participants) in the Medline and Embase databases for a meta-analysis and found that compared to men without baldness, those with AGA had an increased risk of heart disease, and younger men (< 55 years or ≤ 60 years) showed a stronger correlation [ 61 ]. Salvador Arias-Santiago confirmed the association between early onset AGA and a higher cardiovascular risk in men and women groups.…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Comorbidities in Androgenetic Alopecia: A Comprehensive Review

Chen

Xie

Zhang

et al. 2022

Dermatol Ther (Heidelb)

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Androgenetic alopecia is the most common form of hair loss, affecting 85% of men and 40% of women. Androgenetic alopecia is a disease caused by multiple factors, such as genetics, hormones, and systemic diseases; however, the exact cause remains undetermined. Recent studies have found that it is associated with a high incidence of endocrine diseases and other comorbidities. It may not only be a skin disease but also an early signal of underlying systemic diseases. Effective management requires timely diagnosis and treatment initiation. However, in current clinical practice, androgenetic alopecia is still not fully understood or treated. Recognizing the true physical, social, and emotional burden of androgenic alopecia, as well as its associated comorbidities, is the first step in improving the prognosis of affected patients. This review aimed to gather the known pathological factors and provide a reference for clinical physicians to understand androgenetic alopecia and its comorbidities in depth, thereby enabling early recognition of the underlying systemic diseases and providing timely treatment.

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^{Androgenetic Alopecia Is not Associated With Major Vascular Comorbidities: A Retrospective Case‐Control Study of 8230 Patients}

Ong,

Zeldin,

Stone

et al. 2024

JEADV Clinical Practice

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Updated meta-analysis of the relation between heart disease and androgenic alopecia or alopecia areata

Cited by 3 publications

References 13 publications

Alopecia areata is not a risk factor for heart diseases: A 10-year retrospective cohort study

Alopecia areata is not a risk factor for heart diseases: A 10-year retrospective cohort study

Comorbidities in Androgenetic Alopecia: A Comprehensive Review

^{Androgenetic Alopecia Is not Associated With Major Vascular Comorbidities: A Retrospective Case‐Control Study of 8230 Patients}

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