2004
DOI: 10.1097/01.sla.0000129342.67174.67
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Updated Population-Based Review of Carcinoid Tumors

Abstract: Using national, population-based cancer registry data, this study demonstrates that (1) incidence rates for carcinoid tumors have changed, (2) the most common gastrointestinal site is not the appendix (as is often quoted), but the small intestine, followed in frequency by the rectum, and (3) survival rates differ between individual anatomic sites.

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Cited by 491 publications
(450 citation statements)
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“…According to Maggard et al [6] the average age at diagnosis for NETs is 60.9 years and 54.2% of the cases occurred in females. Modlin et al [7] IJBR (2015) 6 (02) www.ssjournals.com conducted a study in 2003 according to which the average age at diagnosis was 61.4 years for patients with carcinoid tumour.…”
Section: Discussionmentioning
confidence: 99%
“…According to Maggard et al [6] the average age at diagnosis for NETs is 60.9 years and 54.2% of the cases occurred in females. Modlin et al [7] IJBR (2015) 6 (02) www.ssjournals.com conducted a study in 2003 according to which the average age at diagnosis was 61.4 years for patients with carcinoid tumour.…”
Section: Discussionmentioning
confidence: 99%
“…Well-differentiated neuroendocrine tumors (WDNTs, carcinoid tumors) of the lung and gastrointestinal tract are uncommon, indolent malignancy, with an age adjusted annual incidence of 2.5-4.5 per 100,000 (Modlin et al, 2003;Maggard et al, 2004). The molecular mechanisms of WDNTs genesis are poorly understood but have been the focus of many recent reviews (Leotlela et al, 2003;Ö berg, 2005;Zikusoka et al, 2005) and reports of genetic and epigenetic alterations (Serrano et al, 2000;Lubomierski et al, 2001;Chan et al, 2003;Karnik et al, 2005;Wang et al, 2005;Yokoyama et al, 2005;Choi et al, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…1,2 Neuroendocrine tumors are divided by their embryological site of origin into foregut carcinoid tumors, comprising tumors from the lung, stomach, duodenum and pancreas; midgut carcinoid tumors, comprising tumors from the jejunum, ileum, appendix and right colon; and hindgut carcinoid tumors, comprising tumors from the left colon and rectum. Tumors originating from the midgut are most common, with the majority located in the ileum.…”
mentioning
confidence: 99%
“…Tumors originating from the midgut are most common, with the majority located in the ileum. 1,2 However, there is heterogeneity among the neuroendocrine tumors of various subsites, including clinicopathologic features, behavior and genetic alterations. For example, the majority of appendiceal carcinoid tumors have benign clinical behavior, but the majority of ileal carcinoid tumors have metastasis at presentation.…”
mentioning
confidence: 99%