“…Well-differentiated neuroendocrine tumors (WDNTs, carcinoid tumors) of the lung and gastrointestinal tract are uncommon, indolent malignancy, with an age adjusted annual incidence of 2.5-4.5 per 100,000 (Modlin et al, 2003;Maggard et al, 2004). The molecular mechanisms of WDNTs genesis are poorly understood but have been the focus of many recent reviews (Leotlela et al, 2003;Ö berg, 2005;Zikusoka et al, 2005) and reports of genetic and epigenetic alterations (Serrano et al, 2000;Lubomierski et al, 2001;Chan et al, 2003;Karnik et al, 2005;Wang et al, 2005;Yokoyama et al, 2005;Choi et al, 2007).…”