Updated Review on the Role of Curcumin in Gastrointestinal Cancers

Naji, Melika; Soroudi, Setareh; Akaberi, Maryam; Sahebkar, Amirhossein; Emami, Seyed Ahmad

doi:10.1007/978-3-030-64872-5_6

Cited by 6 publications

(3 citation statements)

References 147 publications

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“…Curcumin, a natural herb derived from the rhizome or rootstalk of the turmeric plant, has well documented antitumor effects in gastrointestinal related cancers given its immunomodulatory, anti-inflammatory, antioxidant, and prebiotic activities [19]. Further, literature on curcumin's beneficial effects on CIM is now surfacing.…”

Section: Natural Compoundsmentioning

confidence: 99%

Nonpharmacological approaches for improving gut resilience to chemotherapy

Bullard¹,

McDonald²,

Cardaci³

et al. 2022

Current Opinion in Supportive &Amp; Palliative Care

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Purpose of reviewMucositis of the gastrointestinal tract is a debilitating side effect of chemotherapy that negatively influences treatment tolerance and patient life quality. This review will evaluate the recent literature on nonpharmacological strategies that have the potential to improve chemotherapy-induced mucositis (CIM).Recent findingsAlternatives to pharmacological approaches have shown great promise in preventing CIM. Natural products, including curcumin, ginseng, quercetin, and patchouli all show potential in mitigating CIM. In addition, dietary patterns, such as the elemental diet, high fiber diet, and diets high in amino acids have documented benefits in preventing CIM. Perhaps the greatest advancement coming to this arena in recent years is in the field of probiotics. Indeed, research on single species as well as probiotic mixtures show potential in reducing CIM insofar as probiotics are now being suggested for treatment of CIM by governing bodies. Although behavioral interventions including psychological interventions and exercise interventions have shown promise in reducing cancer therapy-related side effects, more work in this domain is warranted and particularly in the context of CIM.SummaryAlternatives to pharmacological approaches show great potential for use in prevention and treatment of CIM and should be further developed for use in the clinic.

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Section: Natural Compoundsmentioning

confidence: 99%

Nonpharmacological approaches for improving gut resilience to chemotherapy

Bullard¹,

McDonald²,

Cardaci³

et al. 2022

Current Opinion in Supportive &Amp; Palliative Care

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“…GC-MSC conditioned medium (GC-MSCs-CM) promoted gastric cancer cell proliferation, migration, and tumor growth through secreted platelet-derived growth factor (PDGF)-DD [ 24 ]. They also enhanced angiogenesis and tumorigenesis by a nuclear factor (NF)-κB and vascular endothelial growth factor (VEGF) and could be inhibited by Curcumin, a bioactive compound [ 25 26 ]. GC-MSC-CM treatment enhanced the proliferation, migration, and angiogenesis of gastric cancer cells, which was more potent than adjacent noncancerous tissues (GCN-MSCs) or BM-MSCs.…”

Section: Ancer-associated Mesenchymal Stem Cells In Gastric Cancermentioning

confidence: 99%

Role of cancer-associated mesenchymal stem cells in the tumor microenvironment: A review

Ding

Wang

2022

Tzu Chi Medical Journal

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A BSTRACT Mesenchymal stem cells (MSCs) were applied to the therapy for degenerative diseases, immune, and inflammation. In tumor microenvironments (TME), different sources of MSCs showed that tumor-promoting and -inhibiting effects were mediated by different signaling pathways. Cancer-associated MSCs (CaMSCs) could be recruited from bone marrow or local tissues and mainly showed tumor-promoting and immunosuppressive effects. The transformed CaMSCs preserve the characteristics of stem cells, but the properties of regulating TME are different. Hence, we specifically focus on CaMSCs and discuss the detailed mechanisms of regulating the development of cancer cells and immune cells. CaMSCs could be a potential therapeutic target in various types of cancer. However, the detailed mechanisms of CaMSCs in the TME are relatively less known and need further study.

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“…The important characteristic and active components extracted from the traditional chinese medicine turmeric have good application prospects and clinical therapeutic potential in the diversity of pharmacological actions ( Kocaadam and Sanlier 2017 ; Hosseini and Hosseinzadeh 2018 ; Hay et al, 2019 ; Liu et al, 2022a ). In a number of studies involving cancer and tumor cells, it was found that curcumin may play a good inhibitory role in a variety of different links ( Mortezaee et al, 2019 ; Zendehdel et al, 2019 ), it effectively inhibits the uncontrolled metastasis of cancer cells ( Jia et al, 2019 ), the proliferation of tumor cells, the activity of cancer-inducing chemicals in the stomach and colon ( Porras et al, 2020 ; Naji et al, 2021 ), and inhibits angiogenesis by modulating protease activity ( Binion et al, 2008 ; Liu et al, 2022b ; Hu et al, 2022 ). However, curcumin has some disadvantages such as poor water solubility, low bioavailability and poor gastrointestinal absorption ( Sabet et al, 2021 ; Sohn et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Application study of curcumin fluorescent complex coated with pharmaceutical excipients for cell imaging

et al. 2023

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Taking curcumin as the starting point, β-cyclodextrin was introduced on both sides, and lipid-soluble curcumin was coated by acrylic resin using oil-in-water strategy. Four different types of curcumin fluorescent complexes EPO-Curcumin (EPO-Cur), L100-55-Curcumin (L100-55-Cur), EPO -Curcumin-β-cyclodextrin (EPO-Cur-β-cd) and L100-55-Curcumin-β-cyclodextrin (L100-55-Cur-β-cd) were prepared to solve their own solubility and biocompatibility issues. The prepared curcumin fluorescent complexes were characterized and tested by spectroscopy. The characteristic peaks of 3446 cm−1 (hydroxyl group), 1735cm−1(carbonyl group) and 1455 cm−1 (aromatic group) were determined in the infrared spectrum. In the fluorescence emission spectrum, it was found that the emission intensity of different curcumin fluorescent complexes in polar solvents reached hundreds of times. Through the transmission electron microscopy shows that acrylic resin tightly coats curcumin into rods or clusters. In order to observe their compatibility with tumor cells more directly, live cell fluorescence imaging was carried out, and it was found that all four kinds of curcumin fluorescence complexes had good biocompatibility. In particular, the effect of EPO-Cur-β-cd and L100-55-Cur-β-cd is better than that of EPO-Cur and L100-55-Cur.

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Updated Review on the Role of Curcumin in Gastrointestinal Cancers

Cited by 6 publications

References 147 publications

Nonpharmacological approaches for improving gut resilience to chemotherapy

Nonpharmacological approaches for improving gut resilience to chemotherapy

Role of cancer-associated mesenchymal stem cells in the tumor microenvironment: A review

Application study of curcumin fluorescent complex coated with pharmaceutical excipients for cell imaging

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