Updated Risk/Benefit Analysis of Fish Consumption Effects on Neurodevelopment: Implications for Setting Advisories

Ginsberg, Gary; Toal, Brian; McCann, Patricia

doi:10.1080/10807039.2014.992851

Cited by 16 publications

(23 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, the Ginsberg et al. (Ginsberg & Toal, ; Ginsberg et al., ) methodology applied to this Great Lakes data set supports the notion that, when considered holistically, fish meals impart health benefits despite PBT burdens.…”

Section: Resultssupporting

confidence: 57%

“…Table displays the data used to generate the PUFA‐3/MeHg nutritional benefit metrics and results. All the fish tested, except for walleye, would impart benefits to reduce cardiovascular risk and promote neurodevelopment when assessed using the Ginsberg and Toal () and Ginsberg et al () methodology. This method assumes a benefit from all PUFA‐3, not just EPA+DHA.…”

Section: Resultsmentioning

confidence: 99%

“…Ginsberg et al. () recently updated the model for infant neural development, which estimates changes in VRM points in children who were exposed in utero to material MeHg. These equations are as follows:

\begin{matrix} true \\ left Net risk / benefit for adult CHD = false[(PUFA) \\ left - 3 mg / meal \times false(no . meals / week false) \times false(1 week / 7 days false) \\ left \times 14 . 6 % lower risk / 100 mg PUFA - 3 false] \\ left - false| false[(hair Hg change / fish meal) \times (no . meals / week) false] \\ left - false(0 . 51 ppm hair Hg false) false| \\ left \times false(23 % higher risk / 1 ppm hair Hg false) \end{matrix}

\begin{matrix} true \\ left Net risk / benefit for infant VRM = false[false(PUFA false) \\ left - 3 mg / meal \times false(no . meals / week false) \\ left \times false(1 week / 7 days false) \times false(3 . 04 VRM points false) \\ left false(/ 100 m g PUFA<...> \end{matrix}

…”

Section: Methodsmentioning

confidence: 99%

“…Ginsberg and Toal () and Ginsberg, Toal, and McCann () have presented a method for comparing the benefits of PUFA‐3 relative to the risks from methylmercury (MeHg) in fish. The estimates consider adult cardiovascular disease risk and infant neurodevelopment risk.…”

Section: Introductionmentioning

confidence: 99%

“…Here, we compare updated contaminant data to PUFA‐3 data in matched fish samples to derive a more accurate assessment of the risk/benefit estimates developed by Ginsberg and Toal () and Ginsberg et al. ().…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Mercury, Polychlorinated Biphenyls, Selenium, and Fatty Acids in Tribal Fish Harvests of the Upper Great Lakes

et al. 2018

View full text Add to dashboard Cite

The Chippewa Ottawa Resource Authority monitors fish contaminants in Anishinaabe (Great Lake Native American) tribal fisheries. This article updates previously reported trends in two persistent bioaccumulative toxic (PBT) substances that are the primary contributors to consumption advisory limits for these fish: methylmercury (MeHg) and polychlorinated biphenyls (PCBs). Also, we report, for the first time, an analysis of nutritional benefit bioindicators and metrics in these same Upper Great Lakes fish harvests: selenium (Se) and omega-3 fatty acids (PUFA-3s). A novel risk/benefit quantification originally presented by Ginsberg et al. is reported here to characterize the tradeoffs between fatty acid benefits and toxic MeHg health outcomes. We also report a Se benefit metric to characterize the possible protective value against MeHg neurotoxicity based on Ralston et al. Congruent with Anishinaabe cultural motivations to consume fish from their ancestral fisheries, nutritional content was high in locally caught fish and, in some respects, superior to farmed/store-bought fish. These Great Lakes fish still contained levels of PBTs that require careful education and guidance for consumers. However, the contaminant trends suggest that these fish need not be abandoned as important (both culturally and nutritionally) food sources for the Anishinaabe who harvested them.

show abstract

Section: Resultssupporting

confidence: 57%

Section: Resultsmentioning

confidence: 99%

\begin{matrix} true \\ left Net risk / benefit for adult CHD = false[(PUFA) \\ left - 3 mg / meal \times false(no . meals / week false) \times false(1 week / 7 days false) \\ left \times 14 . 6 % lower risk / 100 mg PUFA - 3 false] \\ left - false| false[(hair Hg change / fish meal) \times (no . meals / week) false] \\ left - false(0 . 51 ppm hair Hg false) false| \\ left \times false(23 % higher risk / 1 ppm hair Hg false) \end{matrix}

\begin{matrix} true \\ left Net risk / benefit for infant VRM = false[false(PUFA false) \\ left - 3 mg / meal \times false(no . meals / week false) \\ left \times false(1 week / 7 days false) \times false(3 . 04 VRM points false) \\ left false(/ 100 m g PUFA<...> \end{matrix}

…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mercury, Polychlorinated Biphenyls, Selenium, and Fatty Acids in Tribal Fish Harvests of the Upper Great Lakes

et al. 2018

View full text Add to dashboard Cite

show abstract

Considerations and challenges in support of science and communication of fish consumption advisories for per‐ and polyfluoroalkyl substances

Petali,

Pulster,

McCarthy

et al. 2024

Integr Envir Assess & Manag

View full text Add to dashboard Cite

Federal, state, tribal, or local entities in the United States issue fish consumption advisories (FCAs) as guidance for safer consumption of locally caught fish containing contaminants. Fish consumption advisories have been developed for commonly detected compounds such as mercury and polychlorinated biphenyls. The existing national guidance does not specifically address the unique challenges associated with bioaccumulation and consumption risk related to per‐ and polyfluoroalkyl substances (PFAS). As a result, several states have derived their own PFAS‐related consumption guidelines, many of which focus on one frequently detected PFAS, known as perfluorooctane sulfonic acid (PFOS). However, there can be significant variation between tissue concentrations or trigger concentrations (TCs) of PFOS that support the individual state‐issued FCAs. This variation in TCs can create challenges for risk assessors and risk communicators in their efforts to protect public health. The objective of this article is to review existing challenges, knowledge gaps, and needs related to issuing PFAS‐related FCAs and to provide key considerations for the development of protective fish consumption guidance. The current state of the science and variability in FCA derivation, considerations for sampling and analytical methodologies, risk management, risk communication, and policy challenges are discussed. How to best address PFAS mixtures in the development of FCAs, in risk assessment, and establishment of effect thresholds remains a major challenge, as well as a source of uncertainty and scrutiny. This includes developments better elucidating toxicity factors, exposures to PFAS mixtures, community fish consumption behaviors, and evolving technology and analytical instrumentation, methods, and the associated detection limits. Given the evolving science and public interests informing PFAS‐related FCAs, continued review and revision of FCA approaches and best practices are vital. Nonetheless, consistent, widely applicable, PFAS‐specific approaches informing methods, critical concentration thresholds, and priority compounds may assist practitioners in PFAS‐related FCA development and possibly reduce variability between states and jurisdictions. Integr Environ Assess Manag 2024;00:1–20. © 2024 SETAC

show abstract

Use of Traditional and Culturally Appropriate Modalities

Dellinger

2018

Environmental Health Literacy

View full text Add to dashboard Cite

Updated Risk/Benefit Analysis of Fish Consumption Effects on Neurodevelopment: Implications for Setting Advisories

Cited by 16 publications

References 53 publications

Mercury, Polychlorinated Biphenyls, Selenium, and Fatty Acids in Tribal Fish Harvests of the Upper Great Lakes

Mercury, Polychlorinated Biphenyls, Selenium, and Fatty Acids in Tribal Fish Harvests of the Upper Great Lakes

Considerations and challenges in support of science and communication of fish consumption advisories for per‐ and polyfluoroalkyl substances

Use of Traditional and Culturally Appropriate Modalities

Contact Info

Product

Resources

About