Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame

Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)

“…A recent review of human and animal studies concluded that aspartame consumption is not carcinogenic to humans, on the basis of inadequate data 30 . For humans, evidence was based on a large review by the WHO 16 and two later studies 17,18 .…”

“…A recent review of human and animal studies concluded that aspartame consumption is not carcinogenic to humans, on the basis of inadequate data. 30 For humans, evidence was based on a large review by the WHO 16 and two later studies. 17,18 The WHO-commissioned review, which included 48 studies on cancer incidence, reported no association between AS-containing beverages and risk of any cancer in prospective studies (9 studies included, HR = 1.02, 0.95-1.09).…”

The Threat of Food Additive Occurrence in the Environment—A Case Study on the Example of Swimming Pools

“…The studies conducted in these field focused mainly on animals [ 69 ] and indicate a carcinogenic impact on many species [ 70 ]. However, Borghoff et al [ 71 ], after an extensive review of the literature, pointed out that there were no clear or consistent signals of carcinogenicity following aspartame. Bandyopadhyay et al [ 72 ] showed that compounds such as aspartame and sorbitol could induce DNA damage in bone marrow cells.…”

Sweet Taste Receptors and Associated Sweet Peptides: Insights into Structure and Function

“…However, in human, animal, or in vivo mechanistic assays, there is no clear or consistent signal for any tumor type or biologically plausible mechanism leading to carcinogenicity following aspartame exposure. 58 In terms of prospective cohort studies, they remain unable to be ruled out for chance, bias, or confounding as a result of their focus on sweetener consumption rather than aspartame itself. 55 The successful commercialization of aspartame facilitated the emergence of its derivatives neotame, alitame, and advantame.…”

“…In fact, being one of the most extensively studied food ingredients, aspartame holds more than 40 epidemiologic studies, 12 experimental animal cancer studies, and more than 1360 assay end points to evaluate mechanistic activity. However, in human, animal, or in vivo mechanistic assays, there is no clear or consistent signal for any tumor type or biologically plausible mechanism leading to carcinogenicity following aspartame exposure . In terms of prospective cohort studies, they remain unable to be ruled out for chance, bias, or confounding as a result of their focus on sweetener consumption rather than aspartame itself …”