Updates in diagnostics, treatments, and correlations between oral and ocular manifestations of Sjogren's syndrome

Choudhry, Hassaam; Hosseini, Seyed Hadi; Choudhry, Hannaan S.; Fatahzadeh, Mahnaz; Khianey, Reena; Dastjerdi, Mohammad H.

doi:10.1016/j.jtos.2022.08.001

Cited by 10 publications

(8 citation statements)

References 114 publications

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“…Patients with Sjögren’s syndrome may experience a range of oral health complications as a result of xerostomia (dry mouth) caused by the disorder. These complications include [ 20 , 21 , 22 ]: Dental caries: xerostomia can increase the risk of dental caries due to the decreased salivary flow, which results in a decreased ability to neutralize acid and wash away bacteria and food particles. Oral candidosis: xerostomia can lead to an overgrowth of the fungus Candida, which can cause white, sore patches in the oral cavity, known as oral candidosis.…”

Section: Introductionmentioning

confidence: 99%

Association between Sjögren’s Syndrome and Periodontitis: Epidemiological, Fundamental and Clinical Data: A Systematic Review

et al. 2023

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In recent decades, researchers have investigated the bidirectional links between periodontal disease and systemic diseases, and the results have allowed the development of the concept of periodontal medicine. This concept incorporates and analyzes the mutually influential interactions that can occur between periodontitis and systemic diseases such as diabetes mellitus or cardiovascular diseases. Sjögren’s syndrome (SS) is a chronic autoimmune disorder that targets the exocrine glands of the body, such as the lacrimal and salivary glands. The amount of saliva produced may gradually decrease with the progression of the disease, which can have an impact on the structures within the oral cavity. Although the reduction in saliva flow produces negative effects in the oral cavity, a direct association between Sjögren’s syndrome and periodontal disease has not yet been demonstrated. Available studies on this topic have not identified significant differences in the periodontal status of patients with Sjögren’s syndrome and control groups at the clinical and bacteriological levels. On the other hand, other studies on this topic consider that patients with periodontitis have a higher risk of developing Sjögren’s syndrome than the general population. Therefore, the results remain inconclusive, highlighting the need for further complementary studies.

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Section: Introductionmentioning

confidence: 99%

Association between Sjögren’s Syndrome and Periodontitis: Epidemiological, Fundamental and Clinical Data: A Systematic Review

et al. 2023

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“…Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands (1)(2)(3)(4)(5)(6)(7)(8)(9). It affects approximately 1% of the general population and up to 3% of people above the age of fifty, with women accounting for more than 90% of diagnosed cases (10,11).…”

Section: Introductionmentioning

confidence: 99%

Current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren’s syndrome

Santos

Nam²,

Gil³

et al. 2023

Front. Immunol.

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Sjögren’s syndrome is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Although extensive investigation has been done to understand Sjögren’s syndrome, the causes of the disease are as yet unknown and treatments remain largely ineffective, with established therapeutic interventions being limited to use of saliva substitutes with modest effectiveness. A primary feature of Sjögren’s syndrome is uncontrolled inflammation of exocrine tissues and previous studies have demonstrated that lipid-based specialized pro-resolving mediators reduce inflammation and restores tissue integrity in salivary glands. However, these studies are limited to a single specialized pro-resolving lipid mediator’s family member resolvin D1 or RvD1 and its aspirin-triggered epimer, AT-RvD1. Consequently, additional studies are needed to explore the potential benefits of other members of the specialized pro-resolving lipid mediator’s family and related molecules (e.g., additional resolvin subtypes as well as lipoxins, maresins and protectins). In support of this goal, the current review aims to briefly describe the range of current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren’s syndrome, including both strengths and weaknesses of each approach where this information is known. With this article, the possibilities presented by specialized pro-resolving lipid mediators will be introduced to a wider audience in immunology and practical advice is given to researchers who may wish to take up this work.

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“…Sjögren's syndrome (SS)is a chronic inflammatory autoimmune disease involving exocrine glands (1,2). Lymphocytes invade exocrine glandular epithelial cells of the lacrimal gland and salivary gland and lead to secretory dysfunction and subsequent clinical symptoms such as xerostomia and xerophthalmia (2,3). The severe symptoms mentioned above can significantly affect the life quality of patients with SS (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

A randomized controlled trial to verify the irrigation of salivary glands in relieving xerostomia in patients with Sjögren’s syndrome

Zhang

Zhong

et al. 2022

Front. Immunol.

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ObjectiveTo verify the effect of triamcinolone acetonide (TA) and major salivary glands saline irrigation on relieving xerostomia in Sjögren’s syndrome (SS) patients.MethodsThe enrolled 49 SS patients were randomly assigned to the control group (no irrigation, n=16), saline group (irrigation with saline, n=17) and TA group (irrigation with TA, n=16). Fourteen cases of each group were treated differently but received the same examinations. The examinations include unstimulated whole saliva flow (UWS), chewing-stimulated whole saliva flow (SWS), citric acid-stimulated parotid flow (SPF), Clinical Oral Dryness Score (CODS), Xerostomia Inventory (XI) and EULAR SS Patient Reported Index (ESSPRI) of 1 week before irrigation (T0) and 1 week(T1), 8 weeks (T8), 16 weeks (T16) and 24 weeks (T24) after major salivary irrigation.ResultsEach group had 14 cases with completed follow-ups. Both TA and saline irrigation of major salivary glands resulted in higher SWS and SPF of T8, T16 and than those at T0. ESSPRI (oral dryness domain) of T8, T16 and T24 were significantly lower than that at T0, respectively (P < 0.05). SWS and SPF of T8, T16 and T24 in the saline group were significantly higher than in the control group (P< 0.05). XI and ESSPRI (oral dress domain) of T8, T16 and T24 in the saline group were significantly lower than those in the control group, respectively (P< 0.05). SWS and SPF of T16 and T24 in the TA group were significantly higher than in the control group (P< 0.05). All cases with completed follow-up in TA and saline groups were divided into responders and non-responders. Compared with responders, the UWS, SWS, SPF and CODS of T0 in non-responders were significantly increased (P<0.05). Compared with responders, the XI and ESSPRI of T0 in non-responders were significantly decreased (P<0.05).ConclusionThe irrigation of major salivary glands by TA and saline relieve xerostomia in SS patients. Patients with non-severe xerostomia (responders) have better relief after irrigation than patients with severe xerostomia (non-responders).Clinical Trial Registrationwww.chictr.org.cn, identifier (ChiCTR210052314).

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Updates in diagnostics, treatments, and correlations between oral and ocular manifestations of Sjogren's syndrome

Cited by 10 publications

References 114 publications

Association between Sjögren’s Syndrome and Periodontitis: Epidemiological, Fundamental and Clinical Data: A Systematic Review

Association between Sjögren’s Syndrome and Periodontitis: Epidemiological, Fundamental and Clinical Data: A Systematic Review

Current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sjögren’s syndrome

A randomized controlled trial to verify the irrigation of salivary glands in relieving xerostomia in patients with Sjögren’s syndrome

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