Updates in Pathology for Retroperitoneal Soft Tissue Sarcoma

Mack, Tanner; Purgina, Bibianna

doi:10.3390/curroncol29090504

Cited by 23 publications

(25 citation statements)

References 84 publications

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“…This option almost always requires a further surgical incision for harvesting. In addition, a large discrepancy in the diameters of these veins increases technical difficulties and can lead to a higher risk of thrombosis 16 . Techniques such as the spiral saphenous vein graft (SSVG) and the cylindrical superficial femoral vein (SFV) panel graft have been developed to overcome the latter problem, that is, to increase the diameter of the graft 17–19 .…”

Section: Discussionmentioning

confidence: 99%

Inferior vena cava reconstruction with non‐fascial autologous peritoneum: Retrospective study and literature review

Delcarro,

Coubeau

2024

World j. surg.

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BackgroundInferior vena cava (IVC) resection is essential for complete (R0) excision of some malignancies. However, the optimal material for IVC reconstruction remains unclear. Our objective is to demonstrate the efficacy, safety, and advantages of using Non‐Fascial Autologous Peritoneum (NFAP) for IVC reconstruction. To conduct a literature review of surgical strategies for tumors involving the IVC.MethodsWe reviewed all IVC reconstructions performed at our institution between 2015 and 2023. Preoperative, operative, postoperative, and follow‐up data were collected and analyzed.ResultsA total of 33 consecutive IVC reconstructions were identified: seven direct sutures, eight venous homografts (VH), and 18 NFAP. With regard to NFAP, eight tubular (mean length, 12.5 cm) and 10 patch (mean length, 7.9 cm) IVC reconstructions were performed. Resection was R0 in 89% of the cases. Two patients had Clavien–Dindo grade I complications, 2 grade II, 2 grade III and 2 grade V complications. The only graft‐related complication was a case of early partial thrombosis, which was conservatively treated. At a mean follow‐up of 25.9 months, graft patency was 100%. There were seven recurrences and six deaths. Mean overall survival (OS) was 23.4 months and mean disease‐free survival (DFS) was 14.4 months. According to our results, no statistically significant differences were found between NFAP and VH.ConclusionsNFAP is a safe and effective alternative for partial or complete IVC reconstruction and has many advantages over other techniques, including its lack of cost, wide and ready availability, extreme handiness, and versatility. Further comparative studies are required to determine the optimal technique for IVC reconstruction.

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Section: Discussionmentioning

confidence: 99%

Inferior vena cava reconstruction with non‐fascial autologous peritoneum: Retrospective study and literature review

Delcarro,

Coubeau

2024

World j. surg.

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“…Leiomyosarcoma (LMS) accounts for approximately one quarter of retroperitoneal sarcomas and exceptionally may arise as a primary intra-adrenal tumor, putatively of vascular wall origin. 18,19 The shared attributes of smooth muscle neoplasms and PEComa create a diagnostic challenge that has generated much commentary. 20,21 In particular, a spindle cell-rich PEComa with variably eosinophilic cytoplasm may closely simulate a smooth muscle neoplasm.…”

Section: Discussionmentioning

confidence: 99%

PEComa of the Adrenal Gland

Wakefield,

Sadow,

Hornick

et al. 2023

American Journal of Surgical Pathology

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PEComas are a family of mesenchymal neoplasms composed of histologically distinctive perivascular epithelioid cells which demonstrate myomelanocytic differentiation. PEComas of the adrenal gland are very rare and can represent a considerable diagnostic challenge given their morphologic overlap with more common adrenal cortical neoplasms. We present the clinicopathologic features of 7 primary adrenal PEComas. The cohort comprised 5 male and 2 female patients with a median age of 63 years (range: 31 to 71 y). One patient had Birt-Hogg-Dubé syndrome and another had Lynch syndrome; however, none had a history of tuberous sclerosis complex. Histologically, tumors showed nested and/or sheet-like growth and epithelioid cytomorphology with pale-to-eosinophilic granular cytoplasm. Two tumors had an admixed spindle cell component. There was a median of 4 mitoses per 10 HPFs (range: 0 to 8). Necrosis was present in 4 tumors and lymphovascular invasion in 1. Four tumors were classified as malignant. By immunohistochemistry, tumors were positive for HMB-45 (3/7), MITF (3/3), Melan-A (3/7), smooth muscle actin (5/7), desmin (5/7), and caldesmon (1/1). Two tumors were positive for TFE3 (2/4). Inhibin and SF1 were negative in all tumors assessed (0/6). Of 3 patients with available clinical follow-up information, 1 patient developed locally recurrent and metastatic disease (at 18 mo) and was alive with persistent disease at the last follow-up. Two patients had no recurrent or metastatic disease at the last follow-up (60 and 25 mo). Although PEComas of the adrenal gland are rare, pathologists need to be alert to this entity in the differential diagnosis of primary adrenocortical neoplasms. In suspected cases, the judicious use of melanocytic and smooth muscle markers, in addition to TFE3 and markers of adrenocortical differentiation (such as SF1 and inhibin) can assist in diagnosis. As in PEComas arising at other visceral sites, an association with tuberous sclerosis complex seems to be uncommon.

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“…dedifferentiated, mixed, and pleomorphic. 10,11 Welldifferentiated liposarcomas are characterized as slowly growing tumors that do not have metastatic potential and have a low local recurrence rate. As a result, they have excellent clinical outcomes following a successful complete excision.…”

Section: Discussionmentioning

confidence: 99%

Well-Differentiated Liposarcoma as a Case: The Competence of Surgical Treatment was Questioned

AÇAR¹,

ÇİFTÇİ²,

Apı³

2023

Turkiye Klinikleri J Case Rep

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ABS TRACT Sarcomas are malignant tumors arising from skeletal and non-skeletal connective tissue, as well as the peripheral nervous system. Sarcoma is detected in the majority of patients who have a primary retroperitoneal, extra-visceral, unifocal soft tissue mass. Liposarcoma and leiomyosarcoma are the most prevalent histologic types of retroperitoneal sarcoma in adults. Most retroperitoneal liposarcomas are known as low to mild grade tumors. Well differentiated (low grade) liposarcomas are the most prevalent kind and have no potential to metastasize. Atypical lipomatous tumors are defined as those that develop on the body wall, trunk, or extremity. However, the same tumors are called well-differentiated liposarcomas due to their tendency for local recurrence and located in the retroperitoneum, mediastinum, and spermatic cord. In our case, we aimed to present a case that occupies most of the intra-abdominal volume, has associated gastrointestinal system complaints, and eventually was diagnosed as well-differentiated liposarcoma following surgical treatment.

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Updates in Pathology for Retroperitoneal Soft Tissue Sarcoma

Cited by 23 publications

References 84 publications

Inferior vena cava reconstruction with non‐fascial autologous peritoneum: Retrospective study and literature review

Inferior vena cava reconstruction with non‐fascial autologous peritoneum: Retrospective study and literature review

PEComa of the Adrenal Gland

Well-Differentiated Liposarcoma as a Case: The Competence of Surgical Treatment was Questioned

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