Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers

Paner, Gladell P.; Stadler, Walter M.; Hansel, Donna E.; Montironi, Rodolfo; Lin, Daniel W.; Amin, Mahul B.

doi:10.1016/j.eururo.2017.12.018

Cited by 500 publications

(296 citation statements)

References 76 publications

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“…Moreover, the 8th edition of the AJCC staging system was published only very recently. However, there are no changes in stage grouping classification for testicular cancer between the 7th and 8th editions of the staging system . Our nomograms were constructed by integrating an additional four covariates (age at diagnosis, histology, tumor size, and the number of metastases sites) as prognostic indicators to the traditional AJCC staging system.…”

Section: Discussionmentioning

confidence: 99%

A nomogram for predicting survival and retroperitoneal lymph node dissection treatment in patients with resected testicular germ cell tumors

Meyers

Shi

et al. 2019

Journal of Surgical Oncology

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Background and Objectives To build nomogram incorporating potential prognostic factors for predicting survival outcomes of testicular germ cell tumors (TGCT) patients after resection of the primary tumor. Methods Data of TGCT patients from the Surveillance, Epidemiology, and End Results database (2010‐2016) who underwent resection of the primary tumor were collected. Overall survival (OS) and cancer‐specific survival (CSS) were analyzed by using Cox regression models, nomogram, Kaplan‐Meier method, and log‐rank test. Results We identified 7272 TGCT patients. Age at diagnosis, histology, tumor size, American Joint Committee on Cancer (AJCC) staging system, and number of metastases sites were independent prognostic factors and were integrated into nomograms. The nomograms had higher C‐indexes for both OS and CSS compared with the AJCC 7th staging system (0.881 vs 0.831 and 0.895 vs 0.856, respectively). Moreover, the new stratification of risk groups based on the nomograms showed a more significant distinction between Kaplan‐Meier curves for survival outcomes than the AJCC staging system. Retroperitoneal lymph node dissection was associated with statistically improved survival probability in the nomogram middle‐risk group in resected TGCT patients. Conclusion The novel nomogram‐based staging system could provide satisfactory risk stratification and survival prediction ability beyond traditional AJCC staging systems.

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Section: Discussionmentioning

confidence: 99%

A nomogram for predicting survival and retroperitoneal lymph node dissection treatment in patients with resected testicular germ cell tumors

Meyers

Shi

et al. 2019

Journal of Surgical Oncology

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“…Pathological examination of complete transmural sections of the bladder wall was performed to accurately determine the pathological stage. All tumours were staged according to the eight edition of the American Joint Committee on Cancer Staging Manual . All lymph nodes from each designated site were submitted for examination, and representative sections of the surrounding fibroadipose tissue were also examined.…”

Section: Methodsmentioning

confidence: 99%

Robotic cross-folded U-configuration intracorporeal ileal neobladder for muscle-invasive bladder cancer: Initial experience and functional outcomes

Koie

Οhyama

Yoneyama

et al. 2018

Int J Med Robotics Comput Assist Surg

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BackgroundThis study compared the surgical and urinary functional outcomes in patients with muscle‐invasive bladder cancer (MIBC) who underwent robot‐assisted radical cystectomy (RARC) followed by intracorporeal ileal neobladder reconstruction (ICNB) to those in patients who underwent minimum incision endoscopic radical cystectomy (MIE‐RC) followed by extracorporeal ileal neobladder reconstruction (ECNB).Materials and MethodsThis study reviewed the clinical records of 153 consecutive MIBC patients who underwent neoadjuvant chemotherapy followed by radical cystectomy and ileal neobladder reconstruction.ResultsThe operative time in the ICNB group was significantly longer than that in the ECNB group. The median estimated blood loss was significantly less in the ICNB group than in the ECNB group. The neobladder capacity gradually increased in both groups. The maximum neobladder pressure and urethral closure pressure gradually improved in both groups.ConclusionOur initial experience with ICNB was favourable, with acceptable surgical and urinary functional outcomes.

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“…Patients with urinary bladder cancer are stratified by tumour grade and by tumour stage, according to the recently published American Joint Committee on Cancer (AJCC) Staging Manual 8th edition . These parameters guide treatment decisions, and it is important for surgical pathologists to be aware of current staging guidelines for urinary bladder cancer . Unfortunately, a point of confusion in regard to accurate tumour grading and staging may arise due to conflicting and confusing recommendations made by the International Union Against Cancer (UICC) 8th edition, which was published in 2016 .…”

Section: Introductionmentioning

confidence: 99%

Staging of bladder cancer

et al. 2018

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Urothelial carcinoma of the urinary bladder is a heterogeneous disease with multiple possible treatment modalities and a wide spectrum of clinical outcome. Treatment decisions and prognostic expectations hinge on accurate and precise staging, and the recently published American Joint Committee on Cancer (AJCC) Staging Manual, 8th edition, should be the basis for staging of urinary bladder tumours. It is unfortunate that the International Union Against Cancer (UICC) 8th edition failed to incorporate new data which is considered in the AJCC 8th edition. Thus, the AJCC 8th edition is the focus of this review. Several critical changes and clarifications are made by the AJCC 8th edition relative to the 7th edition. Although the most obvious changes in the 8th edition are in the N (i.e. perivesical lymph node involvement now classified as N1) and M (i.e. M1 is subdivided into M1a and M1b) categories, several points are clarified in the T category (e.g. substaging of pT1 should be attempted). Further optimisation, however, is required. No particular method of substaging pT1 is formally recommended. In this review, these modifications are discussed, as well as points, which require further study and optimisation.

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Updates in the Eighth Edition of the Tumor-Node-Metastasis Staging Classification for Urologic Cancers

Cited by 500 publications

References 76 publications

A nomogram for predicting survival and retroperitoneal lymph node dissection treatment in patients with resected testicular germ cell tumors

A nomogram for predicting survival and retroperitoneal lymph node dissection treatment in patients with resected testicular germ cell tumors

Robotic cross-folded U-configuration intracorporeal ileal neobladder for muscle-invasive bladder cancer: Initial experience and functional outcomes

Staging of bladder cancer

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