Updates in the use of radiotherapy in the management of primary and locally-advanced penile cancer

Patel, Akshar; Naghavi, A.O.; Johnstone, Peter A.S.; Spiess, Philippe E.; Grass, G. Daniel

doi:10.1016/j.ajur.2022.05.010

Cited by 6 publications

(8 citation statements)

References 125 publications

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“…External beam radiotherapy (EBRT) is widely accessible and can be very effective to control superficial disease and locally advanced disease, as bulky unresectable tumors if combining it with other treatment [59]. From a recent review by Patel et al [60], EBRT yields a local control rate of 60% (range: 41–69%) with 5-year CSS of 60%. Mild penile edema may develop during the latter part of treatment, accompanied by erythema, radiation dermatitis, and moist desquamation with late side effects, such as necrosis (10%) and meatal stenosis (5%), which are relatively rare [61 ▪ ].…”

Section: External Radiationmentioning

confidence: 99%

“…Accuracy of radiotherapy plays a crucial role in minimizing damage to the surrounding healthy tissues and reducing side effects. To better achieve this objective, a new technique such as brachytherapy has been developed [60,61 ▪ ].…”

Section: External Radiationmentioning

confidence: 99%

“…Recently, a retrospective study of 29 patients enrolled between 2006 and 2020 by Martz et al [60] about HDR brachytherapy, claims 5-y RRFS rate was 82% and CSS 88% against in LDR and PDR brachytherapy series, where summarized data about RRFS rates, in LDR and PDR, were estimated at 87% [60]. Salvage penectomy was required for six patients (20.7%) who experienced local relapse, resulting in a penile preservation rate of 79.3%.…”

Section: Brachytherapymentioning

confidence: 99%

See 2 more Smart Citations

Organ-sparing treatment for T1 and T2 penile cancer: an updated literature review

Scornajenghi

Asero

Bologna

et al. 2023

Current Opinion in Urology

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Purpose of reviewPenile cancer (PeCa) is an orphan disease due to its rare incidence in high-income countries. Traditional surgical options for clinical T1--2 disease, including partial and total penectomy, can dramatically affect patient's quality of life and mental health status. In selected patients, organ-sparing surgery (OSS) has the potential to remove the primary tumor with comparable oncologic outcomes while maintaining penile length, sexual and urinary function. In this review, we aim to discuss the indications, advantages, and outcomes of various OSSs currently available for men diagnosed with PeCa seeking an organ-preserving option. Recent findingsPatient survival largely depends on spotting and treating lymph node metastasis at an early stage. The required surgical and radiotherapy skill sets cannot be expected to be available in all centers. Consequently, patients should be referred to high-volume centers to receive the best available treatments for PeCa. SummaryOSS should be used for small and localized PeCa (T1-T2) as an alternative to partial penectomy to preserve patient's quality of life while maintaining sexual and urinary function and penile aesthetics. Overall, there are different techniques that can be used with different response and recurrence rates. In case of tumor recurrence, partial penectomy or radical penectomy is feasible, without impacting overall survival.

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Section: External Radiationmentioning

confidence: 99%

Section: External Radiationmentioning

confidence: 99%

Section: Brachytherapymentioning

confidence: 99%

See 1 more Smart Citation

Organ-sparing treatment for T1 and T2 penile cancer: an updated literature review

Scornajenghi

Asero

Bologna

et al. 2023

Current Opinion in Urology

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“…Carcinoma of the penis is a rare and debilitating malignancy for which there is limited evidence to support treatment modalities aside from primary surgical resection [1,2]. Regional lymphatic spread is often the most powerful predictor of prognosis and further limits potential treatment options in the context of existing comorbidities [3]. Radiation therapy, despite viability in the treatment of various genitourinary malignancies, is rarely employed in the management of penile cancer beyond early-stage presentations or neoadjuvant control of nodal disease [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Regional lymphatic spread is often the most powerful predictor of prognosis and further limits potential treatment options in the context of existing comorbidities [3]. Radiation therapy, despite viability in the treatment of various genitourinary malignancies, is rarely employed in the management of penile cancer beyond early-stage presentations or neoadjuvant control of nodal disease [1,3,4]. Salvage radiotherapy has not previously been considered in the metastatic setting for penile cancer [5].…”

Section: Introductionmentioning

confidence: 99%

The Utility of Salvage Radiotherapy for an Inoperable Inguinal Recurrence of Squamous Cell Carcinoma of the Penis

Janes,

Johnston,

Organ

et al. 2023

Cureus

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Penile cancer is a rare genitourinary malignancy for which limited treatment options exist beyond primary surgical resection. Metastatic lymphadenopathy represents a particularly poor prognosis with a lack of literature to suggest the effectiveness of radiation or systemic therapies. Our case documents an inguinal recurrence of penile squamous cell carcinoma not amenable to surgical intervention demonstrating complete response to salvage radiotherapy in the palliative setting. These observations propose the need for further research around the utility of radiotherapy in the management of metastatic penile malignancies.

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Brachytherapy and external beam radiation in the management of primary penile cancer – Game changer for organ preservation?

Garaz,

Mirvald,

Spiess

et al. 2024

Cancer Treatment Reviews

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Updates in the use of radiotherapy in the management of primary and locally-advanced penile cancer

Cited by 6 publications

References 125 publications

Organ-sparing treatment for T1 and T2 penile cancer: an updated literature review

Organ-sparing treatment for T1 and T2 penile cancer: an updated literature review

The Utility of Salvage Radiotherapy for an Inoperable Inguinal Recurrence of Squamous Cell Carcinoma of the Penis

Brachytherapy and external beam radiation in the management of primary penile cancer – Game changer for organ preservation?

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