Updates on Age to Start and Stop Colorectal Cancer Screening: Recommendations From the U.S. Multi-Society Task Force on Colorectal Cancer

Age-Stratified Prevalence and Predictors of Neoplasia Among U.S. Adults Undergoing Screening Colonoscopy in a National Endoscopy Registry

“…including the American Cancer Society, U.S. Preventive Services Task Force, and the U.S. Multi-Society Task Force on Colorectal Cancer, have updated their guidelines to recommend CRC screening starting at age 45 years for average-risk individuals. [6][7][8] However, the prevalence of advanced neoplasia and adenomas among averagerisk individuals younger than 50 years has not been well characterized. A few recent studies have examined this topic, [9][10][11] but the generalizability of these findings may be limited by older data, geographic restriction, or modest sample size.…”

Third Asia-Pacific consensus recommendations on colorectal cancer screening and postpolypectomy surveillance

“…The American Cancer Society was the first to propose lowering the screening age for all adults to 45 years 48. The most recent USPSTF recommendation and the US Multi-Society Task Force recommend that asymptomatic adults aged 45 years or older at average risk of CRC (ie, no prior diagnosis of CRC or advanced adenoma, inflammatory bowel disease and no family history of known genetic disorder predisposing to CRC) should receive CRC screening 49 50. This is based on age-period cohort analyses in birth cohorts in the United States and clinical trials of CRC screening that include adults younger than 50 years of age 51 52.…”

Artificial intelligence and machine learning for early detection and diagnosis of colorectal cancer in sub-Saharan Africa

“…Extrapolation of cancer screening recommendations from high-income countries to SSA is often inappropriate due to differences in demographics, disease epidemiology and resources. For example, the average risk screening for CRC is typically recommended at age 50; however, the US Preventive Services Task Force, the American Cancer Society and the US Multisociety Task Force on Colorectal Cancer have recently recommended lowering it to 45 years 16–18. In SSA, estimates from available data indicate that 19%–38% of CRC diagnoses are in persons <40 years of age—a stark contrast to the 1%–7% reported in high-income countries 19–21.…”