Updates on Clinical Study Reports of Phytotherapy in the Management of Type 2 Diabetes Mellitus

Sarker, Md. Moklesur Rahman; Soma, Mahfuza Afroz

doi:10.2174/9789811480515120040003

Cited by 3 publications

(5 citation statements)

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“…Another clinical trial also showed the efficacy of berberine as adjuvant therapy in poorly controlled type 2 diabetic patients ( 32 ). In other clinical trials, berberine also showed promising efficacy compared to rosiglitazone and metformin by reducing HbA1c, fasting blood glucose, postprandial blood glucose despite having some adverse effects on liver ( 33 ). In another 6 months long randomized-controlled trial on 85 type 1 diabetic patients (39 males and 46 females), twice daily intake of a tablet containing 588/105 mg combination of Berberis aristata/Silybum marianum decreased insulin use by the body during insulin therapy.…”

Section: Berberis Aristata DCmentioning

confidence: 99%

“…The same study perceived that reduction in insulin resistance was also significant in the diabetic patients in the group taking N. sativa supplementation compared to the placebo group ( 140 ). Supplementation of Nigella sativa in type 2 diabetes patients was found to improve fasting blood glucose, HbA1c, total- cholesterol, and LDL level significantly ( 33 ). As such, a systematic review done to assess the effect of N. sativa on type 2 diabetes mellitus has also suggested that it could be adjunctively used with other oral antidiabetic medications to manage the disease ( 141 ).…”

Section: Nigella Sativa Lmentioning

confidence: 99%

“…Administration of silymarin in patients with type 2 diabetes resulted in a significant reduction in HbA1c level, fasting plasma glucose (FPG), daily blood glucose average and glucosuria, daily insulin requirement, fasting insulin, as well as an increase in serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and HDL levels. When silymarin was supplemented with glibenclamide in type 2 diabetes patients, a reduction in postprandial hyperglycemia was also observed ( 33 ). A flavonolignans, silychristin A, extracted from Silybum marianum demonstrated a marked reduction of both postprandial and/or fasting hyperglycemia and improvement of the function of β-cells in STZ-induced T1DM.…”

Section: Silybum Marianum (L) Gaertnmentioning

confidence: 99%

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Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

et al. 2022

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Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples’ normal life worldwide. Despite the availability of insulin preparations and several synthetic oral antidiabetic drugs, there is a crucial need for the discovery and development of novel antidiabetic drugs because of the development of resistance and side effects of those drugs in long-term use. On the contrary, plants or herbal sources are getting popular day by day to the scientists, researchers, and pharmaceutical companies all over the world to search for potential bioactive compound(s) for the discovery and development of targeted novel antidiabetic drugs that may control diabetes with the least unwanted effects of conventional antidiabetic drugs. In this review, we have presented the prospective candidates comprised of either isolated phytochemical(s) and/or extract(s) containing bioactive phytoconstituents which have been reported in several in vitro, in vivo, and clinical studies possessing noteworthy antidiabetic potential. The mode of actions, attributed to antidiabetic activities of the reported phytochemicals and/or plant extracts have also been described to focus on the prospective phytochemicals and phytosources for further studies in the discovery and development of novel antidiabetic therapeutics.

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Section: Berberis Aristata DCmentioning

confidence: 99%

Section: Nigella Sativa Lmentioning

confidence: 99%

Section: Silybum Marianum (L) Gaertnmentioning

confidence: 99%

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Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

et al. 2022

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“…3 Despite of having scientific advancement and globalization, medicinal plant based drug discovery is still playing a significant role in the exploration of various pharmacological activities and the discovery of new drugs. 4 In fact, phytomedicines, nutraceuticals, herbal medicines and plant-based different preparations in various dosage forms are extensively investigated by the researchers, herbal and nutraceutical industries aiming to the discovery and development of effective and safe complementary and alternative therapies for the development of medicaments against diabetes, 5 – 8 cancer, 9 – 11 autoimmune and immunocompromised conditions, 12 – 18 inflammation and infectious diseases, 19 – 21 hyperlipidemia 22 , 23 and neurological and adaptogenic problems 24 due to the limitations of conventional drugs, because of the development of drug resistance and adverse effects and chronic toxicities in long term treatment.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Therapeutic Potential of Citrus grandis (L.) Osbeck: A Review

Anmol

Marium

Hiew

et al. 2021

J Evid Based Complementary Altern Med

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Citrus grandis or Citrus maxima, widely recognized as Pomelo is widely cultivated in many countries because of their large amounts of functional, nutraceutical and biological activities. In traditional medicine, various parts of this plant including leaf, pulp and peel are used for generations as they are scientifically proven to have therapeutic potentials and safe for human use. The main objective of this study was to review the different therapeutic applications of Citrus grandis and the phytochemicals associated with its medicinal values. In this article different pharmacological properties like antimicrobial, antitumor, antioxidant, anti-inflammatory, anticancer, antiepileptic, stomach tonic, cardiac stimulant, cytotoxic, hepatoprotective, nephroprotective, and anti-diabetic activities of the plant are highlighted. The enrichment of the fruit with flavonoids, polyphenols, coumarins, limonoids, acridone alkaloids, essential oils and vitamins mainly helps in exhibiting the pharmacological activities within the body. The vitamins enriched fruit is rich in nutritional value and also has minerals like calcium, phosphorous, sodium and potassium, which helps in maintaining the proper health and growth of the bones as well as the electrolyte balance of the body. To conclude, various potential therapeutic effects of Citrus grandis have been demonstrated in recent literature. Further studies on various parts of fruit, including pulp, peel, leaf, seed and it essential oil could unveil additional pharmacological activities which can be beneficial to the mankind.

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“…From the ancient times, natural plants significantly contributed to the discovery and development of many emerging medicines in almost all of the therapeutic categories ( Atanasov et al, 2021 ). In recent days, phytomedicines, nutraceuticals and herbal medicines have attracted the attention of researchers for extensive investigations with an aim of the discovery and development of medicaments for the treatment of diabetes ( Chen et al, 2018 ; Chen et al, 2019 ; Munira et al, 2020 ; Sarker and Soma, 2020 ), cancer ( Sheikh et al, 2017a ; Sheikh et al, 2017b ; Shajib et al, 2018 ), autoimmune and immunocompromised conditions ( Goto et al, 2010 ; Sarker et al, 2011 ; Sarker et al, 2012a ; Sarker et al, 2012b ; Sarker, 2012 ; Sarker et al, 2012 ; Sarker and Gohda, 2013 ; Sarker et al, 2014 ; Sarker et al, 2016 ; Sarker, 2021 ), inflammation and infectious diseases ( Imam et al, 2013 ; Sarker, 2015 ; Rouhi et al, 2017 ; Nesa et al, 2018 ), hyperlipidemia ( Kazemipoor et al, 2015 ; Sarker, 2015 ), and neurological and adaptogenic problems ( Das et al, 2017 ; Ibrahim et al, 2020 ) due to the limitations of conventional drugs because of the development of drug resistance and adverse effects and chronic toxicities in long term treatment. Carica papaya L. is an important medicinal plant which has recently been explored for investigations of its medicinal properties and identification of its bioactive compounds and establishment of their mechanism of actions.…”

Section: Introductionmentioning

confidence: 99%

Dengue Fever: Therapeutic Potential of Carica papaya L. Leaves

2021

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Dengue, a very widespread mosquito-borne infectious disease caused by Aedes aegypti virus, has been occurring during the monsoons every year. The prevalence and incidence of dengue fever and death due to its complications have been increased drastically in these recent years in Bangladesh, Philippines, Thailand, Brazil, and India. Recently, dengue had spread in an epidemic form in Bangladesh, Thailand, and Philippines. Although the infection affected a large number of people around the world, there is no established specific and effective treatment by synthetic medicines. In this subcontinent, Malaysia could effectively control its incidences and death of patients using alternative medication treatment mainly prepared from Carica papaya L. leaves along with proper care and hospitalization. Papaya leaves, their juice or extract, as well as their different forms of preparation have long been used traditionally for treating dengue fever and its complications to save patients’ lives. Although it is recommended by traditional healers, and the general public use Papaya leaves juice or their other preparations in dengue fever, this treatment option is strictly denied by the physicians offering treatment in hospitals in Bangladesh as they do not believe in the effectiveness of papaya leaves, thus suggesting to patients that they should not use them. In Bangladesh, 1,01,354 dengue patients have been hospitalized, with 179 deaths in the year 2019 according to information from the Institute of Epidemiology, Disease Control, and Research as well as the Directorate General of Health Services of Bangladesh. Most of the patients died because of the falling down of platelets to dangerous levels and hemorrhage or serious bleeding. Therefore, this paper aims to critically review the scientific basis and effectiveness of Carica papaya L. leaves in treating dengue fever based on preclinical and clinical reports. Thrombocytopenia is one of the major conditions that is typical in cases of dengue infection. Besides, the infection and impairment of immunity are concerned with dengue patients. This review summarizes all the scientific reports on Carica papaya L. for its ability on three aspects of dengue: antiviral activities, prevention of thrombocytopenia and improvement of immunity during dengue fever.

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Updates on Clinical Study Reports of Phytotherapy in the Management of Type 2 Diabetes Mellitus

Cited by 3 publications

References 0 publications

Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

Phytochemical and Therapeutic Potential of Citrus grandis (L.) Osbeck: A Review

Dengue Fever: Therapeutic Potential of Carica papaya L. Leaves

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