Updates on developing and applying biosensors for the detection of microorganisms, antimicrobial resistance genes and antibiotics: a scoping review

Magnano San Lio, Roberta; Barchitta, Martina; Maugeri, Andrea; La Rosa, Maria Clara; Favara, Giuliana; Agodi, Antonella

doi:10.3389/fpubh.2023.1240584

Cited by 3 publications

(1 citation statement)

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“…Efforts to improve monitoring and diagnostics also extend to the development of biosensors and microfluidic devices capable of detecting antibiotic resistance at the point of care. For instance, researchers have designed microchip-based devices that can rapidly identify drug-resistant bacteria by analyzing their responses to antibiotics [188]. These tools offer the potential for on-site diagnostics and tailored treatment decisions.…”

Section: Latest Strategies Against Drug-resistant Microorganismsmentioning

confidence: 99%

Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative Review

Muteeb,

Rehman,

Shahwan

et al. 2023

Pharmaceuticals

156

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Antibiotics have revolutionized medicine, saving countless lives since their discovery in the early 20th century. However, the origin of antibiotics is now overshadowed by the alarming rise in antibiotic resistance. This global crisis stems from the relentless adaptability of microorganisms, driven by misuse and overuse of antibiotics. This article explores the origin of antibiotics and the subsequent emergence of antibiotic resistance. It delves into the mechanisms employed by bacteria to develop resistance, highlighting the dire consequences of drug resistance, including compromised patient care, increased mortality rates, and escalating healthcare costs. The article elucidates the latest strategies against drug-resistant microorganisms, encompassing innovative approaches such as phage therapy, CRISPR-Cas9 technology, and the exploration of natural compounds. Moreover, it examines the profound impact of antibiotic resistance on drug development, rendering the pursuit of new antibiotics economically challenging. The limitations and challenges in developing novel antibiotics are discussed, along with hurdles in the regulatory process that hinder progress in this critical field. Proposals for modifying the regulatory process to facilitate antibiotic development are presented. The withdrawal of major pharmaceutical firms from antibiotic research is examined, along with potential strategies to re-engage their interest. The article also outlines initiatives to overcome economic challenges and incentivize antibiotic development, emphasizing international collaborations and partnerships. Finally, the article sheds light on government-led initiatives against antibiotic resistance, with a specific focus on the Middle East. It discusses the proactive measures taken by governments in the region, such as Saudi Arabia and the United Arab Emirates, to combat this global threat. In the face of antibiotic resistance, a multifaceted approach is imperative. This article provides valuable insights into the complex landscape of antibiotic development, regulatory challenges, and collaborative efforts required to ensure a future where antibiotics remain effective tools in safeguarding public health.

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Section: Latest Strategies Against Drug-resistant Microorganismsmentioning

confidence: 99%