Updates on larynx cancer epidemiology

Nocini, Riccardo; Molteni, Gabriele; Mattiuzzi, Camilla; Lippi, Giuseppe

doi:10.21147/j.issn.1000-9604.2020.01.03

Cited by 180 publications

(141 citation statements)

References 14 publications

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“…Ключовими факторами ризику РГ є ку рін ня, вживання алкоголю та інфікування онкогенними штамами вірусу папіломи лю дини (ВПЛ) [3,4]. Крім того, обговорюється роль радіаційного опромінення, професійних хімічних чинників і ларингофарингеального рефлюксу (ЛФР) [5,6]. Останній визначено серед найбільш поширених хронічних захворювань дорослих у багатьох розвинутих країнах світу [5].…”

Section: вступunclassified

“…Крім того, обговорюється роль радіаційного опромінення, професійних хімічних чинників і ларингофарингеального рефлюксу (ЛФР) [5,6]. Останній визначено серед найбільш поширених хронічних захворювань дорослих у багатьох розвинутих країнах світу [5]. Проте, незважаючи на численні дослідження, мало відомо про механізми впливу ЛФР на РГ.…”

Section: вступunclassified

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Laringopharingeal Reflux Impacts Immune Microenvironment of Laryngeal Carcinoma

Zabolotnyi¹,

Kizim²,

Zabolotna³

et al. 2020

Fiziol Zh

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The purpose of this study was to evaluate the effect of the laryngopharyngeal reflux (LPR) on the number of tumourinfiltrating T-lymphocytes in laryngeal cancer (LC). According to the results of pH monitoring, 87 patients with laryngeal tumours were subdivided into three groups: 1st group included patients with LC without LPR; 2nd group comprised LC patients with coexisting LPR, patients with benign neoplasms of the larynx with LPR were enrolled into 3d group. TIME was assessed immunohistochemically by counting T-lymphocytes (CD3+), T-cytotoxic cells (CD8+) and T-regulatory cells (Treg; FOXP3+) number within the tumour, in the peritumour stroma, and in the intact areas of the larynx. It was shown that LPR leads to chronic inflammation and affects TIME of laryngeal carcinomas. LC with coexisting LPR demonstrated a higher inflammatory infiltration of tumour area and intact mucosa. However, no statistically significant differences were found between a number of CD3+- and CD8+-cells in LC of the 1st and 2nd groups. In contrast, LPR was associated with higher number of immunosuppressive Treg-cells within tumour and in intact mucosa that could affect immune tolerance and efficacy of anti-tumour immunity facilitating LC progression.

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Section: вступunclassified

Laringopharingeal Reflux Impacts Immune Microenvironment of Laryngeal Carcinoma

Zabolotnyi¹,

Kizim²,

Zabolotna³

et al. 2020

Fiziol Zh

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show abstract

“…However, more than two-thirds of patients are diagnosed with LC when the disease is already at an advanced stage [ 13 – 16 ]. This delay facilitates the growth and spread of LC cells [ 17 ], posing challenges for successful treatment of the disease.…”

Section: Introductionmentioning

confidence: 99%

Laryngeal Squamous Cell Carcinoma: Potential Molecular Mechanism and Prognostic Signature Based on Immune-Related Genes

Huang

et al. 2020

Med Sci Monit

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“…lScc is a highly invasive malignant tumor, which accounts for ~2.4% of the newly diagnosed cases of malignancy worldwide each year (2,3). The pathogenesis of the disease is associated with several factors, including the external environment, genetic factors, poor lifestyle habits and human papillomavirus infection (4,5). at present, the treatment of lScc primarily involves surgical resection, radiotherapy and chemotherapy, which can be used to cure lScc at early stages (6).…”

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA fer‑1‑like family member 4 serves as a tumor suppressor in laryngeal squamous cell carcinoma cells via regulating the AKT/ERK signaling pathway

Jiao

Liu

et al. 2020

Mol Med Rep

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laryngeal squamous cell carcinoma (lScc) is a common type of malignant tumor of the head and neck. an increasing number of studies have illustrated that long non-coding rnas (lncrnas) serve an important role in the occurrence and development of lScc. Therefore, the present study aimed to investigate the expression changes and mechanism of lncrna fer-1-like family member 4 (Fer1l4) in the progression of lScc. The expression levels of Fer1l4 in lScc cell lines (aMc-Hn-8, Tu 686, M4e and M2e) and a normal cell line (HBe135-e6e7) were analyzed using reverse transcription-quantitative Pcr. The Fer1l4 overexpression plasmid (plasmid-Fer1l4) was subsequently transfected into Tu 686 cells to upregulate the expression levels of Fer1l4. cell viability was detected using a cell counting Kit-8 assay, cell proliferation was analyzed using a colony formation assay, apoptosis was examined by flow cytometry, and cell migration and invasion were determined using wound healing and Transwell assays, respectively. in addition, the plasmid-Fer1l4 cells were also treated with insulin-like growth factor 1 (iGF-1) to determine the effect of Fer1l4 on the aKT/erK signaling pathway, and the effect of the plasmid-Fer1l4 on the expression levels of aKT/erK signaling pathway-related proteins were analyzed using western blotting. The results of the present study revealed that Fer1l4 expression levels were downregulated in aMc-Hn-8 and Tu 686 cells. Notably, FER1L overexpression significantly reduced the cell viability, proliferation, migration and invasion of lScc cells, while promoting apoptosis. Meanwhile, the plasmid-FER1L4 also significantly suppressed the phosphorylation levels of aKT and erK. Further studies indicated that the aforementioned changes could be reversed by iGF-1, indicating Fer1l4 may regulate the progression of lScc cells by inhibiting the aKT/erK signaling pathway. in conclusion, the present study provided a potential novel direction for the treatment of lScc in the future and suggested that Fer1l4 may be a new target in this field.

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Updates on larynx cancer epidemiology

Cited by 180 publications

References 14 publications

Laringopharingeal Reflux Impacts Immune Microenvironment of Laryngeal Carcinoma

Laringopharingeal Reflux Impacts Immune Microenvironment of Laryngeal Carcinoma

Laryngeal Squamous Cell Carcinoma: Potential Molecular Mechanism and Prognostic Signature Based on Immune-Related Genes

Long non‑coding RNA fer‑1‑like family member 4 serves as a tumor suppressor in laryngeal squamous cell carcinoma cells via regulating the AKT/ERK signaling pathway

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