Updates on Management of Gastric Cancer

Johnston, Fabian M.; Beckman, Michael J.

doi:10.1007/s11912-019-0820-4

Cited by 357 publications

(287 citation statements)

References 52 publications

Supporting

Mentioning

282

Contrasting

Unclassified

Order By: Relevance

“…In recent years, improved food preservation techniques and new treatments for H. pylori infection allowed a gastric cancer rate decrease. However, screening programs are cost-prohibitive, so gastric cancers are routinely diagnosed only in relative advanced stages, resulting in worse outcome [32]. The WHO classified the gastric cancers in five different subtypes based on histological features: tubular, the most common; papillary, well known as liver-metastasising; and mucinous adenocarcinomas.…”

Section: Top Five Lethal Solid Cancersmentioning

confidence: 99%

See 1 more Smart Citation

Retinoic Acids in the Treatment of Most Lethal Solid Cancers

Costantini

Molinari

Farinon

et al. 2020

JCM

View full text Add to dashboard Cite

Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA) concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 years and used as standard therapy still to date, the same use in solid cancers is still controversial. In the present review the literature about the top five lethal solid cancers (lung, stomach, liver, breast, and colon cancer), as defined by The Global Cancer Observatory of World Health Organization, and retinoic acids (ATRA, 9-cis retinoic acid, and 13-cis retinoic acid, RA) was compared. The action of retinoic acids in inhibiting the cell proliferation was found in several cell pathways and compartments: from membrane and cytoplasmic signaling, to metabolic enzymes, to gene expression. However, in parallel in the most aggressive phenotypes several escape routes have evolved conferring retinoic acids-resistance. The comparison between different solid cancer types pointed out that for some cancer types several information are still lacking. Moreover, even though some pathways and escape routes are the same between the cancer types, sometimes they can differently respond to retinoic acid therapy, so that generalization cannot be made. Further studies on molecular pathways are needed to perform combinatorial trials that allow overcoming retinoic acids resistance.

show abstract

Section: Top Five Lethal Solid Cancersmentioning

confidence: 99%

“…Instead, the signet ring cell carcinoma is a malignant poorly differentiated subtype. The fifth type includes mixed carcinomas with rare variants [32].…”

Section: Top Five Lethal Solid Cancersmentioning

confidence: 99%

Retinoic Acids in the Treatment of Most Lethal Solid Cancers

Costantini

Molinari

Farinon

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…A difference in 5-year survival is shown between lymphatic and hepatic metastases (43% and 40%) compared to peritoneal carcinomatosis of 11%, suggesting that results might differ according to which de nition of oligometastases was used. Patients with peritoneal carcinomatosis are often only treated with best supportive care or palliative chemotherapy, with a median survival of 4 and 7 months, respectively [24]. Our data suggests median survival rates of 13 months for patients with peritoneal carcinomatosis and perioperative chemotherapy followed by surgery, with 15 patients receiving additional HIPEC.…”

Section: Discussionmentioning

confidence: 80%

Perioperative FLOT Chemotherapy Plus Surgery for Oligometastatic Esophagogastric Adenocarcinoma: Surgical Outcome and Overall Survival

Runkel

Verst

Spiegelberg

et al. 2020

Preprint

View full text Add to dashboard Cite

Background:Guidelines do not recommend surgery for patients with oligometastatic disease from esophagogastric adenocarcinoma (EGAC), although some studies suggest a more favourable survival. We analyzed the outcome of oligometastatic EGAC receiving FLOT chemotherapy followed by surgery. Methods:The data of patients with either pre-therapeutic, post-neoadjuvant or intraoperative clinical diagnosis of oligometastatic EGAC were extracted from a prospective database of the 2009-2018 treatment period. 48 consecutive patients were identified with oligometastatic disease, who underwent perioperative chemotherapy plus surgery. We retrospectively analyzed surgical outcome and overall survival. Results:The overall 5-year survival was 18 %. 12 patients with pre-therapeutic oligometastatic EGAC, who had no histologic vital tumor evidence of metastases after surgery had a survival rate of 48 % compared to an 11 % 5-year survival rate of 36 patients, who had histologic vital tumor metastatic evidence after FLOT chemotherapy and surgical resection (p=0.012). The survival rates after R0, R1 and R2 (non-resected metastases) resection were 21 % (n=33), 0 % (n=4) and 17 % (n=11), respectively (p=0.273).Conclusion:Oligometastatic EGAC is associated with poor overall survival even after complete resection of all tumor manifestations. The subgroup of patients with a complete pathohistologic response of metastatic lesions to neoadjuvant FLOT shows 5-year survival rates similar to non-metastatic EGAC. Trial registration: Not applicable

show abstract

“…Liver cancer was the fourth cause of death for malignancy after gastric cancer, non-Hodgkin lymphoma and colorectal cancer, with a standardized mortality ratio of 2.9 (95% CI 0.1-5.9) compared to AIRTUM data. Although liver cancer is not prevalent in CVID, liver, as a secondary lymphoid organ, is a frequent extra-nodal localization of non-Hodgkin lymphoma, as well as a common metastatic target of gastrointestinal adenocarcinomas (80)(81)(82)(83)(84)(85). Therefore, diagnostic protocols aiming to oncologic surveillance in CVID patients should always encompass clinical, laboratory and imaging assessment of liver to rule out its primary or secondary neoplastic involvement.…”

Section: Malignanciesmentioning

confidence: 99%