Updates on synthesis and biological activities of 1,3,4-oxadiazole: A review

Salahuddin,; Mazumder, Avijit; Yar, Mohammad Shahar; Mazumder, Rupa; Chakraborthy, G. S.; Ahsan, Mohamed Jawed; Rahman, Mujeeb Ur

doi:10.1080/00397911.2017.1360911

Cited by 74 publications

(33 citation statements)

References 80 publications

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“…Nalidixic acid our starting compound has better antibacterial and antifungal activities than synthesized Hydrazones, Oxadiazoles and their respective copper complexes. Our result are close agreement with results of Popiołek and Gawrońska-Grzywacz (2015) and Salahuddin et al (2017).…”

Section: Biological Activitiessupporting

confidence: 93%

Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

Int¹

2019

Preprint

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A series of novel 1, 3, 4-oxadiazole analogues was synthesized from cyclization of hydrazones of substituted 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8naphthyridine-3-carbohydrazides were prepared from nalidixic acid. The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1 H-NMR and atomic absorption spectral analysis. It was observed from spectral data that metal ligand ratio was 1:1 in all copper complexes and they were bidentate, coordination was found to be done through oxygen of 4-oxo group and nitrogen of oxadiazole ring. The synthesized compounds were further evaluated with biological activities and compared with parent hydrazones. Copper complexes possess antibacterial and antifungal activities better than the oxadiazoles while they have better antioxidant activity then copper complexes. Parent hydrazones were better in all biological activities than synthesized oxadiazoles.Capsule Summary: A series of novel 1,3,4-oxadiazole analogues was synthesized from cyclization of hydrazone. The synthesized compounds showed considerable biological activities than synthesized oxadiazoles. Cite This ArticleAs: F. Deeba, N. Abbas, M. T. Butt, R. A. Khan, M. M. Ahsan and M. A. Khan. Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes.

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Section: Biological Activitiessupporting

confidence: 93%

Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

Int¹

2019

Preprint

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“…1,3,4‐Oxadiazole derivatives have found a broad spectrum of uses, ranging from pharmacophores with antibacterial, anti‐inflammatory and anticancer properties, [1–2] to electron transporting materials in organic light emitting diodes (OLEDS) [3–4] . The functionality has also found use as a bioisostere for carboxylic acids, esters and amides in medicinal chemistry, and exhibits favorable physicochemical properties when compared to the related 1,2,4‐isomer [5–7] …”

Section: Methodsmentioning

confidence: 99%

UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow

Green

Livingstone

Bertrand

et al. 2020

Chemistry A European J

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Ar ange of 1,3,4-oxadiazoles have been synthesized using aU V-Ba ctivated flow approachs tarting from carboxylic acidsa nd 5-substitutedt etrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approacha nd has demonstrated comparable efficiencya nd versatility,w ith ad iverse substrate scope, including the incorporation of highly substituted amino acids.

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“…Oxadiazoles are aromatic heterocyclic rings containing one oxygen and two nitrogen atoms occupying different ring positions as in 1,2,3- [42], 1,2,4- [43,44], 1,2,5- [45], and 1,3,4-oxadiazoles [46,47] (Figure 5). Depending on the relative position of nitrogen and oxygen atoms, these classes of oxadiazoles possess different characteristics.…”

Section: Classes Of Translational Readthrough-inducing Drugs (Trids)mentioning

confidence: 99%

Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs)

Campofelice

Lentini

Leonardo

et al. 2019

IJMS

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This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations. These mutations in specific genes generate premature termination codons (PTCs) responsible for the translation of truncated proteins. After a brief introduction on nonsense mutations and their pathological effects, the features of various classes of TRIDs will be described discussing differences or similarities in their mechanisms of action. Strategies to correct the PTCs will be presented, particularly focusing on a new class of Ataluren-like oxadiazole derivatives in comparison to aminoglycosides. Additionally, recent results on the efficiency of new candidate TRIDs in restoring the production of the cystic fibrosis transmembrane regulator (CFTR) protein will be presented. Finally, a prospectus on complementary strategies to enhance the effect of TRIDs will be illustrated together with a conclusive paragraph about perspectives, opportunities, and caveats in developing small molecules as TRIDs.

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Updates on synthesis and biological activities of 1,3,4-oxadiazole: A review

Cited by 74 publications

References 80 publications

Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

UV‐Induced 1,3,4‐Oxadiazole Formation from 5‐Substituted Tetrazoles and Carboxylic Acids in Flow

Strategies against Nonsense: Oxadiazoles as Translational Readthrough-Inducing Drugs (TRIDs)

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