Updates on the Management of Diabetic Macular Edema with New-Generation Intravitreal Injectable Drugs

Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature

“…However, not all peptides that are assembled in ribosomeindependent pathways are termed NRPs, excluding important examples such as peptidoglycan 6 and glutathione. 7 Numerous other peptides whose biosynthesis involves neither ribosomes nor NRPSs are classied by function (e.g. siderophores 8 ) rather than by biosynthetic origin.…”

“…1D). 7 Although the enzymes responsible for peptide bond formation in glutathione biosynthesis are not related to those commonly described for NIS (IucA/IucC protein family), 32 there is a shared biosynthetic logic (ATP-dependent, not CP-mediated) with aerobactin or staphyloferrin B 8 biosynthesis, for example. In these cases, the amide bond is formed using the carboxylic group of citrate and a free amine of a specic substrate.…”