Updating hippocampal representations: CA2 joins the circuit

Jones, Matthew W.; McHugh, Thomas J.

doi:10.1016/j.tins.2011.07.007

Cited by 114 publications

(118 citation statements)

References 134 publications

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“…An alternative and, in our view, equally likely explanation is that CA2 provides an alternate route of information transfer, either as a compensatory mechanism or as a separate system that bypasses CA3 altogether (Chevaleyre and Siegelbaum 2010). Furthermore, lesion studies support this hypothesis (for review, see Jones and McHugh 2011).…”

Section: Role For Ca2 In Learning and Memorymentioning

confidence: 78%

New insights into the regulation of synaptic plasticity from an unexpected place: Hippocampal area CA2

2012

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The search for molecules that restrict synaptic plasticity in the brain has focused primarily on sensory systems during early postnatal development, as critical periods for inducing plasticity in sensory regions are easily defined. The recent discovery that Schaffer collateral inputs to hippocampal area CA2 do not readily support canonical activity-dependent long-term potentiation (LTP) serves as a reminder that the capacity for synaptic modification is also regulated anatomically across different brain regions. Hippocampal CA2 shares features with other similarly "LTP-resistant" brain areas in that many of the genes linked to synaptic function and the associated proteins known to restrict synaptic plasticity are expressed there. Add to this a rich complement of receptors and signaling molecules permissive for induction of atypical forms of synaptic potentiation, and area CA2 becomes an ideal model system for studying specific modulators of brain plasticity. Additionally, recent evidence suggests that hippocampal CA2 is instrumental for certain forms of learning, memory, and social behavior, but the links between CA2-enriched molecules and putative CA2-dependent behaviors are only just beginning to be made. In this review, we offer a detailed look at what is currently known about the synaptic plasticity in this important, yet largely overlooked component of the hippocampus and consider how the study of CA2 may provide clues to understanding the molecular signals critical to the modulation of synaptic function in different brain regions and across different stages of development.

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Section: Role For Ca2 In Learning and Memorymentioning

confidence: 78%

New insights into the regulation of synaptic plasticity from an unexpected place: Hippocampal area CA2

2012

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“…A direct projection from CA2 to layer II of MEC has been suggested as a monosynaptic alternative (figure 2) [54], but this projection has not been confirmed by others [55]. Whether or not to welcome CA2 as a new player in the field of place-to-grid cell interactions remains thus to be seen, although the unique integrative responses of CA2 neurons make them likely key players in the grid-to-place cell interactions [56,57]. The required excitatory drive may also come from local excitatory networks in MEC, embedded in layer II through non-stellate cells or feedback loops between the layers [32,33,58,59].…”

Section: Layer II Medial Entorhinal Cortex Network Generates Grid Celmentioning

confidence: 99%

Architecture of spatial circuits in the hippocampal region

Witter

Canto

Couey

et al. 2014

Phil. Trans. R. Soc. B

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The hippocampal region contains several principal neuron types, some of which show distinct spatial firing patterns. The region is also known for its diversity in neural circuits and many have attempted to causally relate network architecture within and between these unique circuits to functional outcome. Still, much is unknown about the mechanisms or network properties by which the functionally specific spatial firing profiles of neurons are generated, let alone how they are integrated into a coherently functioning meta-network. In this review, we explore the architecture of local networks and address how they may interact within the context of an overarching space circuit, aiming to provide directions for future successful explorations.

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“…Among the sensory cues rodents use to communicate, olfactory cues are of critical importance. Interestingly, interaction with cagemates who have just consumed novel flavored food resulted in the subject choosing food of the same flavor in preference to a completely novel flavored food [19,[21][22][23], suggesting that rodents exchange meaningful information through olfactory signals. Pheromones are another important type of sensory cue that rodents relay upon.…”

Section: Manifestation and Assessment Of Social Dysfunctions In Animamentioning

confidence: 99%

Hippocampal CA2 Region: A New Player in Social Dysfunctions

Mou¹

2016

J Neurol Neurophysiol

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For social species, normal social cognitive functions are essential for individuals to survive in a social group. Various neuropsychiatric disorders, including schizophrenia, autism and bipolar disorder are characterized by the impairments in social cognition. The hippocampus has been at the forefront of research in learning and memory for several decades. Hippocampal dysfunction contributes to learning and memory impairments as well as a range of social dysfunctions. However, precise contributions of different hippocampal sub-regions to differential aspects of cognitive functions remain unclear. This review first describes several key features of social abnormalities related to neuropsychiatric disorders, and then introduces the behavioral tasks used in animal models to assess each feature. Second, it gives a basic description of CA2 anatomy followed by an overview of its known functions. Third, it highlights a number of recent findings that associate the abnormalities of the hippocampal CA2 area and social dysfunctions in both animal models and human patients.

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Updating hippocampal representations: CA2 joins the circuit

Cited by 114 publications

References 134 publications

New insights into the regulation of synaptic plasticity from an unexpected place: Hippocampal area CA2

New insights into the regulation of synaptic plasticity from an unexpected place: Hippocampal area CA2

Architecture of spatial circuits in the hippocampal region

Hippocampal CA2 Region: A New Player in Social Dysfunctions

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