Updating on the pathogenesis of systemic lupus erythematosus

Gualtierotti, Roberta; Biggioggero, Martina; Penatti, Alessandra; Meroni, Pier Luigi

doi:10.1016/j.autrev.2010.09.007

Cited by 175 publications

(120 citation statements)

References 47 publications

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“…The pathogenesis of these diseases is multifactorial and involves abnormalities in both innate and adaptive immunity. The increased expression of proinflammatory cytokines such as TNF-α and IL-6 has been related to the induction of the diseases (62,63). Thus, dysregulated expression of VentX in macrophages may play a role in the pathogenesis of autoimmune diseases.…”

Section: Figurementioning

confidence: 99%

The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation

Gao²,

Ke³

et al. 2011

J. Clin. Invest.

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Macrophages are critical players in both innate and adaptive immunity. While the exogenous signaling events leading to the terminal differentiation of macrophages from monocytes have been studied extensively, the underlying intracellular transcriptional mechanisms remain poorly understood. Here we report that the homeobox transcription factor VentX plays a pivotal role in human macrophage terminal differentiation and proinflammatory function. Our study showed that VentX expression was upregulated upon human primary monocyte-to-macrophage differentiation induced by cytokines such as M-CSF, GM-CSF, and IL-3. Moreover, ablation of VentX expression in primary monocytes profoundly impaired their differentiation to macrophages, and ectopic expression of VentX in a myeloid progenitor cell line triggered its differentiation with prominent macrophage features. Further analysis revealed that VentX was pivotal for the proinflammatory response of terminally differentiated macrophages. Mechanistically, VentX was found to control expression of proteins key to macrophage differentiation and activation, including M-CSF receptor. Importantly, preliminary analysis of gene expression in leukocytes from patients with autoimmune diseases revealed a strong correlation between levels of VentX and those of proinflammatory cytokines. Our results provide mechanistic insight into the crucial roles of VentX in macrophage differentiation and proinflammatory activation and suggest that dysregulation of VentX may play a role in the pathogenesis of autoimmune diseases.

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Section: Figurementioning

confidence: 99%

The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation

Gao²,

Ke³

et al. 2011

J. Clin. Invest.

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“…However, now it is widely accepted that SLE occurs in phases during a period of time that can be also of years. Therefore, the following steps in the development process of SLE have been suggested: i) genetic predisposition, ii) gender as an additional predisposing factor, iii) environmental stimuli which start immune responses, iv) appearance of autoantibodies, v) regulation of the autoantibodies, T and B cell fails with the development of the clinical disease, vi) chronic inflammation and oxidative damage as causes of tissue damage influencing morbidity (Gualtierotti, 2010).…”

Section: Sle the Diseasementioning

confidence: 99%

Genetics and Epigenetic in Systemic Lupus Erythematosus

AlFadhli¹

2012

Systemic Lupus Erythematosus

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“…Innate and adaptive immunity contribute to the mechanism of diseases (1). Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that is characterized by immune complex accumulation in blood vessels and connective tissue (2).…”

Section: Introductionmentioning

confidence: 99%

Epigenetics in systemic lupus erythematosus

Xiao

Zuo

2015

Biomedical Reports

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Abstract. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, with mechanisms that remain to be elucidated. Previous studies have proposed that genes and environments are required for lupus to develop and flare. It has been found that epigenetics have a significant influence on SLE. The present review will concentrate on epigenetics in SLE. There are a number of studies reporting that autoreactive T cells and B cells in patients with SLE have evidence of altered patterns of DNA methylation, modifications of histones and microRNA (miRNA). Long noncoding RNAs (lncRNAs) are another type of noncoding RNAs, which have an important role in epigenetics. lncRNAs may possibly become a new hotspot in SLE.

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Updating on the pathogenesis of systemic lupus erythematosus

Cited by 175 publications

References 47 publications

The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation

The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation

Genetics and Epigenetic in Systemic Lupus Erythematosus

Epigenetics in systemic lupus erythematosus

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