“…Despite these efforts, a substantial lack of legislation can be still noted 21 , though improvements are in progress as recently demonstrated by the public consultation to update of the CLP legislation 41 , focusing one of the key topics on the importance to take into account the effects of mixtures of chemicals [42][43][44] and highlight the challenges they pose to both risk assessors and risk managers, i.e. to both toxicology and public law.…”