This paper investigates the effects of earthquakes’ duration, intensity, and magnitude on the seismic response of reinforced concrete (RC) bridges retrofitted with seismic bearings, such as elastomeric bearings (EB), lead rubber bearings (LRB), and friction pendulum bearings (FPB). In order to investigate the effects of the seismic isolation, the condition of the deck with a rigid connection on the cap beams and abutments (i.e., without isolation) was investigated as the first model. The EB, LRB and FPB bearings are used between the superstructure and substructure of the studied bridge in the second, third and fourth models, respectively. First, the effects of using seismic bearings on the seismic retrofit of an RC bridge under the Tabas earthquake were investigated. The results of the nonlinear dynamic analysis showed that the use of seismic bearings leads to seismic retrofit of the studied bridge, and FPB and LRB had the best results among the studied isolation equipment, respectively. The same models were also studied subjected to the Landers and Loma Prieta earthquakes. The magnitude of the Landers and Tabas earthquakes is equal to 7.3 Richter, and the magnitude of the Loma Prieta earthquake is equal to 6.7 Richter. However, the duration and intensity of the Landers and Loma Prieta earthquakes are much larger than the Tabas earthquake. The Landers and Loma Prieta earthquakes caused instability in the isolated models due to their significant duration and intensity. This issue shows that using seismic bearings is very useful and practical for seismic retrofitting bridges subjected to far-fault earthquakes. According to most seismic codes, selecting earthquakes in far-region of faults is based on just magnitude criterion. However, this study indicates that there are two main factors in the features of far-fault earthquakes, including duration and intensity. Ignoring these factors in selecting earthquakes may lead to the instability of structures. Considering earthquakes’ duration, intensity, and magnitude are vital for selecting earthquakes in the far region of the fault.